Inclusion Complex Formation between α‐Cyclodextrin and Biodegradable Aliphatic Polyesters

Abstract

Inclusion complexes (ICs) between alpha-cyclodextrin (alpha-CD) and three kinds of biodegradable aliphatic polyesters with different sequence lengths of the monomeric repeating units poly(3-hydroxypropionate) [P(3HP)], poly(4-hydroxybutyrate) [P(4HB)] and poly(epsilon-caprolactone)(PCL) were prepared by mixing a solution of alpha-CD with that of the polymer, followed by stirring. The ICs were obtained as insoluble precipitates and characterized by FT-IR, WAXD and DSC. All measurements showed that the polymer chains of all three kinds of polyester were included into the alpha-CD cavity and formed ICs with different stoichiometries. WAXD patterns and thermal analysis indicated that these ICs possessed a channel structure and the crystallization of the polyester chains was suppressed upon inclusion into the alpha-CD cavity.

Synthesis of novel nanoreinforcements for polymer matrices by ATRP: Triblock poly(rotaxan)s based in polyethyleneglycol end-caped with poly(methyl methacrylate)

“…Methyl methacrylate (MMA, Aldrich, 99%) was purified by passage through a short column of activated basic alumina before using to remove inhibitors and acidic impurities. Copper bromide (Cu(I)Br) (Aldrich, 99%) was purified according to the method of Keller and Wycoff [16]. N,N Dimethylformamide (DMF) (Scharlau, 98%) was degassed by bubbling nitrogen for thirty minutes and in all experiments MilliQ grade water was used.…”

“…The best known are those formed by six to nine glucose units called a (6), b (7), g (8) and d (9) CD respectively. It is generally accepted that Van der Waals interactions play an important role in host guest associations between cyclodextrines and small molecules [12,13] or polymers [14,15] where the hydrophobic properties of the inner cavity of cyclodextrines are of great importance [16,17].…”

Crystallization, melting behavior, and wettability of poly(ε‐caprolactone) and poly(ε‐caprolactone)/ poly(N‐vinylpyrrolidone) blends

“…[18][19][20][21] However, its hydrophobic property and semicrystalline nature impart difficulties in developing more advanced biomaterials from PCL, 22,23 because hydrophobic property can lead to slow down degradation kinetics and lacking surface recognition functions for specific mucoadhesion or receptor recognition. [24][25][26] For improving the desired properties of PCL, many researchers have synthesized PCL copolymers or blends such as PCL/ PEG, 27 PCL/polysaccharides, [28][29][30] PCL/PVC, 31 as well as incorporated various functional groups into PCL. 32,33 Even some PCL-based organic-inorganic hybrid materials have also been synthesized by solgel method.…”

Thermomechanical behavior and nonisothermal crystallization kinetics of poly(ε-caprolactone) and poly(ε- caprolactone)/poly(N-vinylpyrrolidone) blends

“…It can be used in different biomedical applications, such as in scaffolds, tissue engineering, and for controlled release of drugs [1][2][3][4]. By now, many researchers have synthesized PCL copolymers or blends such as PCL/PEG [5], PCL/polysaccharides [6][7][8], PCL/PVC [9], as well as incorporated various functional groups into PCL [10,11]. Even some PCL-based organic-inorganic hybrid materials have also been synthesized by sol-gel method [12].…”