Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle for gambogic acid

Ji, Ying; Shan, Shuo; He, Mingyu; Chu, Chih‐Chang

doi:10.1016/j.actbio.2017.08.036

Cited by 45 publications

(13 citation statements)

References 46 publications

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“…The fluorescence intensity increased after the 6 hr incubation time. The Nile Red loaded NPs were accumulated in the cytoplasm and the phenomenon was similar with NP materials in other studies (He et al, 2017; Ji et al, 2017b). Ji.…”

Section: Discussionsupporting

confidence: 79%

“…However, GA still faces several technical challenges which limits its clinic application, including very poor water solubility, short half‐life and lacking of target effect on tumor sites. As a result, encapsulating GA into nanoparticles is a better strategy to overcome the deficiency of GA as an effective anticancer drug (Ji, Shan, He, & Chu, 2017b; Kang et al, 2018; Wang et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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Development of ROS‐responsive amino acid‐based poly(ester amide) nanoparticle for anticancer drug delivery

Chu

2020

J Biomedical Materials Res

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Reactive oxygen species (ROS) play an important role in cellular metabolism and many oxidative stress related diseases. Oxidative stress results from toxic effects of ROS and plays a critical role in the pathogenesis of a variety of diseases like cancers and many important biological processes. It is known that the unique feature of high intracellular ROS level in cancer cells can be considered as target and utilized as a useful cancer‐related stimulus to mediate intracellular drug delivery. Therefore, biomaterials responsive to excess level of ROS are of great importance in biomedical applications. In this study, a novel ROS‐responsive polymer based on L‐methionine poly(ester amide) (Met‐PEA‐PEG) was designed, synthesized, characterized and self‐assembled into nano‐micellar‐type nanoparticles (NP). The Met‐PEA‐PEG NP exhibited responsiveness to an oxidative environment. The size and morphology of the nanoparticle changed rapidly in the presence of H2O2. The Nile Red dye was loaded into the Met‐PEA‐PEG NP to demonstrate a H2O2 concentration induced time‐dependent release behavior. The Met‐PEA‐PEG NP was sensitive to high intracellular ROS level of PC3 prostate cancer cells. Furthermore, the Met‐PEA‐PEG NP was investigated as a carrier of a Chinese medicine‐based anticancer component, gambogic acid (GA). Compared to free GA, the GA‐loaded nanocomplex (GA‐NP) showed enhanced cytotoxicity toward PC3 and HeLa cells. The GA‐NP also induced a higher level of apoptosis and mitochondrial depolarization in PC3 cells than free GA. The Met‐PEA‐PEG NP improved the therapeutic effect of GA and may serve as a potential carrier for anticancer drug delivery.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Development of ROS‐responsive amino acid‐based poly(ester amide) nanoparticle for anticancer drug delivery

Chu

2020

J Biomedical Materials Res

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“…The results evidenced that the HA(CD)-4Phe4 nanocomplex significantly induced apoptotic cell death and effectively inhibited tumor metastasis via suppressing the MMP activities in MDA-MB-435/MDR cells. 118 International Journal of Nanomedicine 2020:15 submit your manuscript | www.dovepress.com…”

Section: Nanocomplexmentioning

confidence: 99%

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Liu

Chen

Lin

et al. 2020

IJN

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Gambogic acid (GA), a kind of dry resin secreted by the Garcinia hanburyi tree, is a natural active ingredient with various biological activities, such as anti-cancer, anti-inflammatory, antioxidant, anti-bacterial effects, etc. An increasing amount of evidence indicates that GA has obvious anti-cancer effects via various molecular mechanisms, including the induction of apoptosis, autophagy, cell cycle arrest and the inhibition of invasion, metastasis, angiogenesis. In order to improve the efficacy in cancer treatment, nanometer drug delivery systems have been employed to load GA and form micelles, nanoparticles, nanofibers, and so on. In this review, we aim to offer a summary of chemical structure and properties, anti-cancer activities, drug delivery systems and combination therapy of GA, which might provide a reference to promote the development and clinical application of GA.

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“…Among the amino acids for AA-PEA synthesis, arginine (Arg) is the most unique for two reasons: capable of retaining cationic charge over a wide range of pH due to its strong basic guanidine group with an isoelectric point of 10.96 and pKa above 12.5 as well as its biological property. The former character makes Arg suitable to form electrostatic nanocomplex with other negatively charged biomaterials or payloads [41][42][43][44]. Because of Arg's role in wound healing, free Arg supplement to wound patients has been suggested and reported.…”

Section: Introductionmentioning

confidence: 99%

Accelerate Healing of Severe Burn Wounds by Mouse Bone Marrow Mesenchymal Stem Cell-Seeded Biodegradable Hydrogel Scaffold Synthesized from Arginine-Based Poly(ester amide) and Chitosan

Alapure

Lü

et al. 2018

Stem Cells and Development

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Severe burns are some of the most challenging problems in clinics and still lack ideal modalities. Mesenchymal stem cells (MSCs) incorporated with biomaterial coverage of burn wounds may offer a viable solution. In this report, we seeded MSCs to a biodegradable hybrid hydrogel, namely ACgel, that was synthesized from unsaturated arginine-based poly(ester amide) (UArg-PEA) and chitosan derivative. MSC adhered to ACgels. ACgels maintained a high viability of MSCs in culture for 6 days. MSC seeded to ACgels presented well in third-degree burn wounds of mice at 8 days postburn (dpb) after the necrotic full-thickness skin of burn wounds was debrided and filled and covered by MSC-carrying ACgels. MSC-seeded ACgels promoted the closure, reepithelialization, granulation tissue formation, and vascularization of the burn wounds. ACgels alone can also promote vascularization but less effectively compared with MSC-seeded ACgels. The actions of MSC-seeded ACgels or ACgels alone involve the induction of reparative, anti-inflammatory interleukin-10, and M2-like macrophages, as well as the reduction of inflammatory cytokine TNFα and M1-like macrophages at the late inflammatory phase of burn wound healing, which provided the mechanistic insights associated with inflammation and macrophages in burn wounds. For the studied regimens of these treatments, no toxicity was identified to MSCs or mice. Our results indicate that MSC-seeded ACgels have potential use as a novel adjuvant therapy for severe burns to complement commonly used skin grafting and, thus, minimize the downsides of grafting.

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Inclusion complex from cyclodextrin-grafted hyaluronic acid and pseudo protein as biodegradable nano-delivery vehicle for gambogic acid

Cited by 45 publications

References 46 publications

Development of ROS‐responsive amino acid‐based poly(ester amide) nanoparticle for anticancer drug delivery

Development of ROS‐responsive amino acid‐based poly(ester amide) nanoparticle for anticancer drug delivery

Gambogic Acid as a Candidate for Cancer Therapy: A Review

Accelerate Healing of Severe Burn Wounds by Mouse Bone Marrow Mesenchymal Stem Cell-Seeded Biodegradable Hydrogel Scaffold Synthesized from Arginine-Based Poly(ester amide) and Chitosan

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