Inclusion Complex of α-Cyclodextrin with Poly(ethylene glycol) Brush

Takahashi, Shoko; Yamada, Norifumi L.; Ito, Kohzo; Yokoyama, Haruki

doi:10.1021/acs.macromol.6b01238

Cited by 29 publications

(33 citation statements)

References 14 publications

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“…It was found that the addition of α-CD affected the structure of the grafted layer, which caused the extension of PEG chains into the bulk, allowing for the formation of a polypseudorotaxane (Figure 7). Recently, Yokoyama et al [150], investigated the formation of inclusion complexes between α-CD and a poly(ethylene glycol) brush and observed a similar phenomenon. It was found that a polypseudorotaxane consisting of randomly oriented α-CD polycrystals appeared when the PEG brush was exposed to a 10% α-CD solution.…”

Section: α-Cyclodextrin/polymer Brush-based Polypseudorotaxane Hydrogelsmentioning

confidence: 81%

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

2019

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Supramolecular hydrogels that are based on inclusion complexes between α-cyclodextrin and (co)polymers have gained significant attention over the last decade. They are formed via dynamic noncovalent bonds, such as host-guest interactions and hydrogen bonds, between various building blocks. In contrast to typical chemical crosslinking (covalent linkages), supramolecular crosslinking is a type of physical interaction that is characterized by great flexibility and it can be used with ease to create a variety of "smart" hydrogels. Supramolecular hydrogels based on the self-assembly of polypseudorotaxanes formed by a polymer chain "guest" and α-cyclodextrin "host" are promising materials for a wide range of applications. α-cyclodextrin-based polypseudorotaxane hydrogels are an attractive platform for engineering novel functional materials due to their excellent biocompatibility, thixotropic nature, and reversible and stimuli-responsiveness properties. The aim of this review is to provide an overview of the current progress in the chemistry and methods of designing and creating α-cyclodextrin-based supramolecular polypseudorotaxane hydrogels. In the described systems, the guests are (co)polymer chains with various architectures or polymeric nanoparticles. The potential applications of such supramolecular hydrogels are also described.

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Section: α-Cyclodextrin/polymer Brush-based Polypseudorotaxane Hydrogelsmentioning

confidence: 81%

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

2019

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“…33 PEG chains penetrate into the cavities of α -CD, which are further strengthened via hydrogen bonds between neighboring α -CD on the same PEG chain. 33–35 Due to hydrophobic interaction, a crystalline microregion between α -CD can be self-assembled as a physical cross-linking point. Acrylamide (AM) is often used to initiate polymerization into polyacrylamide, which can form covalent network hydrogel under certain conditions.…”

Section: Introductionmentioning

confidence: 99%

PEG-α-CD/AM/liposome @amoxicillin double network hydrogel wound dressing—Multiple barriers for long-term drug release

Wang

et al. 2021

J Biomater Appl

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Wound infection and poor wound healing are the major challenges of wound treatment. Antibiotic drug treatment is the effective way to inhibit wound infection. It is necessary to achieve sustained release of antibiotics to get a longer treatment for wound infection. The double network hydrogels based on liposome, polyethylene glycol (PEG), α- cyclodextrin ( α-CD) and acrylamide (AM) were developed, in which liposome acts as amoxicillin repository. Because the drug would release from the multiple barriers including two cavities of liposome and α-CD, as well as polyethylene glycol - α- cyclodextrin/acrylamide (PEG-CD/AM) double network, the PEG- α-CD/AM/liposome @amoxicillin double network hydrogels could achieve sustained drug release. The drug release assay showed that the dressing could release amoxicillin continuously until 12 days, than that of 8th day for single-network hydrogel releasing. The antibacterial ratio of the hydrogel could reach above 80%. What’s more, the hydrogels present adjustable mechanical strength by changing the ratio of the components. The swelling ratio proved that the hydrogel had potential ability to absorb wound exudates. The cytotoxicity test of the hydrogels demonstrated excellent biocompatibility. These results indicated that this study can provide a new thought for antibacterial wound dressing and has a broad application prospect.

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“…The first reported host-guest complexation utilizing α-CD is an inclusion complex formation between α-CD and polyethylene glycol (PEG) [16]. PEG chains penetrate into the cavities of α-CDs to form pseudopolyrotaxanes, which are further strengthened via hydrogen bonds between neighboring α-CDs on the same PEG chain[17–19].…”

Section: Introductionmentioning

confidence: 99%

Branched polyrotaxane hydrogels consisting of alpha-cyclodextrin and low-molecular-weight four-arm polyethylene glycol and the utility of their thixotropic property for controlled drug release

Wang

Williamson

2018

Colloids and Surfaces B: Biointerfaces

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In this work, we developed a new class of branched polyrotaxane hydrogel made of 4-arm polyethylene glycol (4-PEG) and α-cyclodextrin (α-CD) using supramolecular host-guest interactions as a cross-linking strategy. Because of the dynamic nature of the non-covalent host-guest cross-linking, the resulting supramolecular α-CD/4-PEG hydrogels show thixotropic behavior and undergo a reversible gel-sol transition in response to shear stress change. We loaded the antiglaucoma drug brimonidine into the α-CD/4-PEG gel and found the drug release kinetics was controlled by shear stress. This thixotropic shear thinning property makes the supramolecular hydrogels highly attractive in drug delivery applications and suitable for preparation of injectable drug formulations.

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Inclusion Complex of α-Cyclodextrin with Poly(ethylene glycol) Brush

Cited by 29 publications

References 14 publications

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

α-Cyclodextrin-Based Polypseudorotaxane Hydrogels

PEG-α-CD/AM/liposome @amoxicillin double network hydrogel wound dressing—Multiple barriers for long-term drug release

Branched polyrotaxane hydrogels consisting of alpha-cyclodextrin and low-molecular-weight four-arm polyethylene glycol and the utility of their thixotropic property for controlled drug release

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