Inconsistent Lipid Profiles Exhibited Among the Diabetic Asian Indians of India and Trinidad–a Comparative Study

Objective: Type 1 diabetes mellitus (T1DM) is a widespread metabolic disease, which frequently carries with it a significant impact on human health. Oxidative damage and tissue inflammation have been claimed to be a typical pathogenic component for the progression of diabetic complications. We aim in this study to explore the relation of urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodG) (as a marker of nucleic acid oxidation) to microvascular complications in T1DM.Methods: A case–control study, enrolling 45 T1DM children and an equivalent number of healthy subjects, was performed. Full clinical examination and anthropometric measurement were performed to all subjects. Urinary assessment for 8-oxodG and albumin was done in addition to blood sampling for lipid profile and glycated Hb (HbA1c) assay. Complete ocular examination for assessment of diabetic retinopathy (DR) was also done.Results: Levels of urinary 8-oxodG, serum cholesterol, triglycerides, and low-density lipoprotein in cases were significantly higher than non-diabetics; these levels were likewise higher in uncontrolled T1DM patients in comparison with well-controlled T1DM subjects. Urinary 8-oxodG and HbA1c were significantly higher in diabetic patients with albuminuria and DR compared to patients without complications. Significant positive correlation was found between 8-oxodG with HbA1c (r=0.8, p<0.01), diastolic blood pressure (DBP) (r=0.4, p=0.02), and cholesterol (r=0.4, p=0.05).Conclusion: Urinary 8-oxodG was found to be a reliable marker for assessing oxidative DNA damage in T1DM and can be used in the determination of microvascular complications related to diabetes.

Section: Discussionsupporting

confidence: 90%

Urinary Markers of Oxidative Dna Damage in Type 1 Diabetic Children: Relation to Microvascular Complications

Wakeel¹,

Abou-El-Asrar²,

El-Kassas³

et al. 2017

“…Another study carried out among rural elderly in China reported the similar prevalence of high cholesterol (18.13%), while prevalence of high triglyceride (12.21%), low HDL cholesterol (32.76%), and high LDL cholesterol (13.23%) was lower compared to our findings [9]. Asian Indians have an abnormal fat distribution which makes it more prone to dyslipidemia [10].…”

Section: Discussionsupporting

confidence: 53%

Dyslipidemia Among the Elderly in Slums of West Delhi

Gonmei

Dwivedi

Toteja

et al. 2018

Objective: The objective of this study is to assess the prevalence of dyslipidemia among the elderly in slums of West Delhi. Methods:A cross-sectional study was carried out in slums of West Delhi covering a total of 234 elderly aged 60 and above. 5 ml blood was collected from 103 elderly and was analyzed for serum total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol by enzymatic method using fully automatic analyzer (Roche Hitachi-902). Dyslipidemia was defined using the National Cholesterol Education Program, ATP-III guidelines. Results:The overall prevalence of high cholesterol (≥200 mg/dl), high triglyceride (≥150 mg/dl), low HDL cholesterol (male -<40 mg/dl; female -<50 mg/dl), and high LDL cholesterol (≥130 mg/dl) was 20.39%, 45.63%, 64.08%, and 17.31%, respectively. Conclusion:Low HDL cholesterol and high triglyceride were the most form of dyslipidemia among the elderly. Awareness on dietary and lifestyle modification for management of dyslipidemia needs to be imparted.

“…Trend analysis of over two decades using data of two representative cross-sectional surveys conducted among men and women aged 35-64 years, residing in urban and rural areas (survey 1 [1991][1992][1993][1994], and survey 2 [2010][2011][2012]) in the National Capital Region of Delhi indicated that rapid rise in the burden of risk factors such as overweight, raised blood pressure, and raised blood glucose [12]. Indian diabetic population is also reported to have lower HDL-C and higher LDL [13].…”

Section: Discussionmentioning

confidence: 99%

Assessment of Risk Factors of Hypertension Among Adults Residing in Urban Slum of Delhi.

Dwivedi

Gonmei

Toteja

et al. 2018

Objective: The objective of this study is to assess the risk factors of hypertension among adults residing in urban slums of West Delhi. Methods:A cross-sectional study was carried out among adult population of 18-59 years residing in urban slums of West Delhi. Blood pressure was measured twice using digital machine (OMRON). Height, waist circumference, and hip circumference were measured, weight was taken, and body mass index (BMI) was calculated. The Joint National Committee VII criteria were used to define hypertension, and the National Cholesterol Education Program and Adult Treatment Panel-III guidelines were used to define different categories of dyslipidemia. The World Health Organization (2014) criteria were used to classify the BMI. Results:The overall prevalence of hypertension among adults (n=423) was 25.3%. Among hypertensive adults, the prevalence of obesity was 22.7%, while among non-hypertensives, it was 10.9%. Similarly, overweight prevalence was higher (27.3%) in hypertensive adults compared to non-hypertensive adults (20.6%). The overall prevalence of hypercholesterolemia, hypertriglyceridemia, high-density lipoprotein-cholesterol <40/<50 mg/dl, and low-density lipoprotein-cholesterol (LDL-C) ≥130 was 19.7%, 33.7%, 75.7%, and 21.8%, respectively. The prevalence of hypercholesterolemia, hypertriglyceridemia, and serum LDL-C ≥130 mg/dl was 38%, 50%, and 32% among hypertensive adults, while among nonhypertensive adults, it was 15%, 29%, and 19%, respectively. Conclusion:Hypertensive adults had higher BMI, serum cholesterol, triglycerides, and LDL-C compared to non-hypertensives.