Incorporating the airway microbiome into asthma phenotyping: Moving toward personalized medicine for noneosinophilic asthma

Durack, Juliana; Boushey, Homer A.; Huang, Yvonne J.

doi:10.1016/j.jaci.2017.05.026

Cited by 5 publications

(7 citation statements)

References 13 publications

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“…; the use of antibiotics increased the likelihood of colonization by Streptococcus, Haemophilus and Moraxella . ( Figure 4 ) [ 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Pathogenesis Of Respiratory Disordersmentioning

confidence: 99%

The Human Respiratory System and its Microbiome at a Glimpse

Santacroce

Charitos

Ballini

et al. 2020

Biology

143

101

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The recent COVID-19 pandemic promoted efforts to better understand the organization of the respiratory microbiome and its evolution from birth to adulthood and how it interacts with external pathogens and the host immune system. This review aims to deepen understanding of the essential physiological functions of the resident microbiome of the respiratory system on human health and diseases. First, the general characteristics of the normal microbiota in the different anatomical sites of the airways have been reported in relation to some factors such as the effect of age, diet and others on its composition and stability. Second, we analyze in detail the functions and composition and the correct functionality of the microbiome in the light of current knowledge. Several studies suggest the importance of preserving the micro-ecosystem of commensal, symbiotic and pathogenic microbes of the respiratory system, and, more recently, its relationship with the intestinal microbiome, and how it also leads to the maintenance of human health, has become better understood.

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“…; the use of antibiotics increased the likelihood of colonization by Streptococcus, Haemophilus and Moraxella . ( Figure 4 ) [ 52 , 53 , 54 , 55 , 56 , 57 , 58 ].…”

Section: Pathogenesis Of Respiratory Disordersmentioning

confidence: 99%

The Human Respiratory System and its Microbiome at a Glimpse

Santacroce

Charitos

Ballini

et al. 2020

Biology

143

101

View full text Add to dashboard Cite

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“…Given that subtypes of T2-low asthma are poorly understood but microbial associations implicated (16)(17)(18)36), we enquired whether distinct patterns of lower airway inflammation exist among the T2-low AAs in our cohort and, if so, whether these associate with bacterial community differences in IS or OW. Using unsupervised clustering we found that levels of immune cytokines in BAL differentiated T2-low AAs into two distinct clusters (Figure 3A), with subjects in inflammatory cytokine cluster (ICC) 1 exhibiting elevated levels of IL-8, IL-6, IL-7, and MIP-3a (q<0.1; Table S17).…”

Section: T2-low Mild Asthmatics With Elevated Lung Pro-inflammatory Cytokines Exhibit Lower Sputum Bacterial Diversitymentioning

confidence: 99%

“…Studies of sputum have described associations between neutrophilic severe asthma and the relative abundance of organisms representing potential respiratory pathogens such as members of the Moraxella and Haemophilus genera (14)(15)(16)(17)(18). However, possible relationships between eosinophilic asthma and sputum microbiota remain obscure.…”

mentioning

confidence: 99%

Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma

Durack

Christian²,

Nariya

et al. 2020

Journal of Allergy and Clinical Immunology

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“…The increasing incidence of asthma in early life suggests that prenatal environmental exposure may influence susceptibility to allergic airway diseases [1][2][3]. Indeed, recent studies suggested Data Availability Statement: DNA sequences corresponding to the 16S rRNA gene data have been deposited in DDBJ under accession number DRA010221.…”

Section: Introductionmentioning

confidence: 99%

“…The increasing incidence of asthma in early life suggests that prenatal environmental exposure may influence susceptibility to allergic airway diseases [ 1 – 3 ]. Indeed, recent studies suggested that prenatal exposure to air pollution enhanced the risk of developing asthma in offspring [ 4 – 6 ].…”

Section: Introductionmentioning

confidence: 99%

Maternal supplementation with Bifidobacterium breve M-16V prevents their offspring from allergic airway inflammation accelerated by the prenatal exposure to an air pollutant aerosol

et al. 2020

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Bifidobacterium breve M-16V is a probiotic bacterial strain with efficacy in infants achieved by suppressing T-helper type (Th) 2 immune responses and modulating the systemic Th1/ Th2 balance. Exposure to air pollution during pregnancy increases asthma susceptibility in offspring. The aim of this study was to investigate the effects of the maternal intake of B. breve M-16V on susceptibility to asthma accelerated by prenatal exposure to air pollution. The intake of B. breve M-16V in residual oil fly ash (ROFA)-exposed pregnant mice resulted in fewer eosinophils in the bronchoalveolar lavage fluid of neonatal mice and reduced allergic lung inflammation. The expressions of Th2 cytokines including IL-5 and IL-13 were decreased in neonatal mice from ROFA-exposed mothers fed B. breve M-16V. The analysis of fecal microbiota from neonatal mice revealed that the intake of B. breve M-16V by mothers changed the composition of fecal microbiota in neonatal mice, which resulted in a decreased population of Firmicutes. Moreover, several bacterial strains of fecal microbiota from neonatal mice had a strong correlation with Th2 cytokines and histological score. These results suggest that the maternal intake of M-16V might have beneficial effects in neonates by preventing and/or alleviating allergic reactions accelerated by prenatal exposure to air pollution.

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Incorporating the airway microbiome into asthma phenotyping: Moving toward personalized medicine for noneosinophilic asthma

Cited by 5 publications

References 13 publications

The Human Respiratory System and its Microbiome at a Glimpse

The Human Respiratory System and its Microbiome at a Glimpse

Distinct associations of sputum and oral microbiota with atopic, immunologic, and clinical features in mild asthma

Maternal supplementation with Bifidobacterium breve M-16V prevents their offspring from allergic airway inflammation accelerated by the prenatal exposure to an air pollutant aerosol

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