Increase in HCV Incidence among Men Who Have Sex with Men in Amsterdam Most Likely Caused by Sexual Transmission

Laar, T.J.W. van de; Bij, Akke K. van der; Prins, Maria; Bruisten, Sylvia M.; Brinkman, Kees; Ruys, Thomas A.; Meer, J.T.M. van der; Vries, Henry J C de; Mulder, J.; Agtmael, Michiel A. van; Jurriaans, Suzanne; Wolthers, Katja C.; Coutinho, Roel A.

doi:10.1086/518796

Cited by 259 publications

(214 citation statements)

References 42 publications

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“…Molecular typing of HCV isolates confirmed the presence of MSM-specific transmission networks in London [25], Paris [26] and Amsterdam [27]. A collaborative phylogenetic study revealed that these locally reported outbreaks were in fact part of one larger interconnected European transmission network [22].…”

Section: As Well As In the Unitedmentioning

confidence: 77%

“…However, recent outbreaks of acute HCV among HIV-positive MSM who deny IDU suggest that the epidemiology of HCV transmission is changing in this population. In several European countries [25][26][27] …”

Section: Hepatitis Bmentioning

confidence: 99%

“…Rough sexual techniques, such as fisting; a higher number of sexual partners and group sex; co-infection with ulcerative STI such as syphilis, herpes, and lymphogranuloma venereum (LGV); sex under the influence of drugs (especially when applied anally); the use of rectal enema; and the presence of haemorrhoids have been identified as potential risk factors for sexually acquired HCV [25,30,33]. However, these factors cannot explain why there was no evidence of sexual transmission in the 1980s, a period in which STI and sexual risk taking were highly prevalent among MSM [27].…”

Section: As Well As In the Unitedmentioning

confidence: 99%

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Viral hepatitis among men who have sex with men, epidemiology and public health consequences

et al. 2009

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Viral hepatitis causes major disease burden worldwide, due to the chronic hepatitis sequelae: cirrhosis and primary liver cancer. Transmission of viral hepatitis is a problem not only in low-income countries, but also in high-income ones where viral hepatitis is a frequently occurring infection among men who have sex with men (MSM). Although the transmission routes of the three main hepatitis viruses, A, B and C, differ, MSM mainly acquire viral hepatitis during sexual contact. Vaccination programmes (only available for hepatitis A and B), raising awareness, and screening can be used to prevent transmission. However, despite the introduction of such methods in many high-income countries, the spread of viral hepatitis among MSM is still ongoing. This paper provides an overview of sexually acquired hepatitis A, B, and C among MSM in high-income countries, using recent insights obtained through molecular epidemiology, with the aim to raise awareness, improve vaccination coverage, and stimulate prevention programs.

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Section: As Well As In the Unitedmentioning

confidence: 77%

Section: Hepatitis Bmentioning

confidence: 99%

Section: As Well As In the Unitedmentioning

confidence: 99%

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Viral hepatitis among men who have sex with men, epidemiology and public health consequences

et al. 2009

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“…6,7 The sexual transmission of HCV is ineffi cient, and the exact risk related to different types of sexual activity is unknown; nevertheless, it has been increasing among HIV-infected men who have sex with men (MSM). 8 The introduction of highly active antiretroviral therapy (HAART) has signifi cantly improved life expectancy of HIV-infected patients; however, the consequences of hepatitis C have become more apparent, as a result either of decompensated cirrhosis or hepatotoxicity due to HAART. 9,10,11 The interaction of those viruses has been the object of great concern, being considered one of the most important public health problems faced by health professionals and authorities worldwide.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology of HIV/HCV coinfection in patients cared for at the Tropical Medicine Foundation of Amazonas

Victoria¹,

Victoria²,

Torres³

et al. 2010

Braz J Infect Dis

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We declare no confl ict of interest. ABSTRACTThe association of HIV infection and hepatitis C virus (HCV) infection often occurs because both viruses share the same transmission routes, increasing the possibility of HIV/HCV coinfection. World prevalence greater than 30% of coinfected cases is estimated, and it can reach 90% depending on the transmission route. With the aim of determining the frequency and profi le of HIV/HCV coinfected patients, a descriptive analysis was carried out with patients with HIV/AIDS whose serology was positive for hepatitis C virus (HCV), cared for at the Fundação de Medicina Tropical do Amazonas from 2000 to 2007. In the present study, of the 2,653 AIDS cases notifi ed in SINAN, 1,582 patients underwent serology test for hepatitis C, and a frequency of 4.42% (n = 70) of HIV/HCV coinfected patients was identifi ed in the period studied. The most frequent infection route was sexual transmission (84.3%), 68.6% among heterosexual individuals. Most patients were males (72.9%), aged between 25 and 40 years (60.1%), of low income (50% earning up to one minimum wage), and low educational level (80% had completed only middle school). A high percentage of deaths were observed during the study (34.3%). The results indicate a low seroprevalence of HIV/HCV coinfection in this population, in which sexual transmission, characterized by sexual promiscuity among heterosexual individuals, is the major transmission route of the virus rather than the use of injection drugs, as shown in world statistics.

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“…İntravenöz ilaç kullanımı olan HIV/AIDS hastalarında HCV ko-enfeksiyonu %50-95 arasında görülmüştür [18] . Bununla birlikte HCV cinsel yolla nadir bulaşmasına rağmen bazı çalışmalar HIV ile enfekte homoseksüellerde cinsel yolla bulaş riskinin yüksek olduğunu vurgulamışlardır [19][20][21] . Çalışmamızdaki üç hastanın ikisinde (%66) intravenöz ilaç kullanımı ve heteroseksüel ilişki öyküsü vardı.…”

Section: Discussionunclassified

Seroprevalence of Hepatitis B and Hepatitis C Virus in HIV/AIDS Patients at Gaziantep University

Şahin¹,

Şahin²,

Namıduru³

et al. 2016

mjima

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Giriş: İnsan immün yetmezlik virüsü (Human immunodeficiency virus-HIV) ya da AIDS (Edinsel İmmünYetmezlikIntroduction: Human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS) have major effect on the morbidity and mortality related with hepatitis B (HBV) and C virus (HCV) infections. Several observational studies suggest that HIV/HBV and HIV/HCV coinfected patients may have higher rates of fibrosis progression and an increased risk of cirrhosis, end-stage liver disease, and hepatocellular carcinoma than patients with HBV and HCV infection alone. Hepatocellular carcinoma also occurs at an earlier age among HIV-infected patients compared to HIV-seronegative patients. In our study, we aimed to investigate the seroprevalence of HBV and HCV co-infections because of common transmission route in patients with HIV/AIDS. Materials and Methods: We retrospectively evaluated 113 HIV/AIDS patients followed by the Infectious Diseases and Clinical Microbiology Clinic at Gaziantep University Şahinbey Training and Application Hospital between 2011 and 2016. Demographic data of patients, HIV transmission routes, enzyme-linked immunosorbent assay results of HBV surface antigen (HBsAg), anti-HBsAg, anti-HBcAg immunoglobulin (Ig) total and anti-HCV serology, and real-time polymerase chain reaction results of serum HBV DNA and HCV RNA levels were obtained from patient records. Results: Ninety-four (83.2%) of 113 HIV/AIDS patients were male and 19 (16.8%) were female. The average age of the patients was 40.22±11.41 years. Eight patients (7%) were positive for HBsAg, 31 (27-4%) for anti-HBcAg total Ig, six (5%) for isolated anti-HBcAg Ig total 47 (41.5%) for anti-HBsAg and three (2.6%) subjects were positive for anti-HCV. All patients who were exposed to HBV were heterosexual. Of the three patients exposed to HCV, two (66.6%) were intravenous drug user. Symptoms of cirrhosis were not observed in HIV/HBV co-infected patients, while one HIV/HCV co-infected patient but one HIV/HCV co-infected patient. Conclusion: Because of the common transmission routes of HBV, HCV and HIV, serologic and virologic markers of hepatitis are necessary for both diagnosis and treatment of co-infections. Co-infection affects chronic hepatitis progression. This is important to avoid possible complications such as cirrhosis. Therefore, all patients with HIV infection should be followed for HBV and HCV.

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Increase in HCV Incidence among Men Who Have Sex with Men in Amsterdam Most Likely Caused by Sexual Transmission

Cited by 259 publications

References 42 publications

Viral hepatitis among men who have sex with men, epidemiology and public health consequences

Viral hepatitis among men who have sex with men, epidemiology and public health consequences

Epidemiology of HIV/HCV coinfection in patients cared for at the Tropical Medicine Foundation of Amazonas

Seroprevalence of Hepatitis B and Hepatitis C Virus in HIV/AIDS Patients at Gaziantep University

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