Increase in Papillary Thyroid Cancer Incidence Is Accompanied by Changes in the Frequency of the<i>BRAF<sup>V600E</sup></i>Mutation: A Single-Institution Study

Kowalska, Aldona; Walczyk, Agnieszka; Kowalik, Artur; Pałyga, Iwona; Trybek, Tomasz; Kopczyński, Janusz; Kajor, Maciej; Chrapek, Magdalena; Pięciak, Liliana; Chłopek, Małgorzata; Góźdż, Stanisław; Kamiński, Grzegorz

doi:10.1089/thy.2015.0352

Cited by 37 publications

(35 citation statements)

References 37 publications

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“…Data suggested that a high iodine intake could be a risk factor for BRAF (T1799A) mutation in the thyroid gland. Similar data have recently been obtained in a Polish institution [24]. In this study, the authors analyzed the frequency of BRAF (V600E) mutation, demonstrating the significant increase of mutation in PTCs patients.…”

Section: Eating Habitssupporting

confidence: 72%

Nutritional and Environmental Factors in Thyroid Carcinogenesis

Nettore

Colao

Macchia

2018

IJERPH

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Several epidemiological studies suggest an increased incidence of thyroid carcinoma (TC) in recent years, especially for the papillary histotype (PTC), suggesting that specific carcinogens might promote molecular abnormalities that are typical of PTC. The increased incidence is probably attributed to more intensive and sensitive diagnostic procedures, even if recent data suggest that various toxic elements could explain the phenomenon. Ionizing radiation exposure represents the most accepted risk factor for differentiated thyroid cancer that includes both the follicular and papillary histotypes. In this review, we examined the other environmental carcinogens that play a role in TC, such as eating habits, living in volcanic areas, and xenobiotic elements. Among eating habits, iodine intake represents one of the more discussed elements, because its deficiency is associated with follicular thyroid carcinomas (FTCs), while its progressive increment seems to be responsible for PTC. The gas, ash, and lava emissions of volcanoes are composed of various toxic compounds that pollute ground water, vegetables, and animals, contaminating humans via the food chain. Finally, the risk of developing PTC has also been associated with exposure of the population to xenobiotics in the environment or in the home. Their carcinogenic effects are probably caused by their accumulation, but additional studies are necessary to better understand the mechanisms of action.

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Section: Eating Habitssupporting

confidence: 72%

Nutritional and Environmental Factors in Thyroid Carcinogenesis

Nettore

Colao

Macchia

2018

IJERPH

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“…2, [5][6][7] Studies have demonstrated that genetic and epigenetic alterations play important roles in the development of PTC. 8,9 However, the underlying molecular mechanisms remain poorly characterized. Therefore, clarifying the mechanisms associated with the pathogenesis of PTC may help to improve the therapeutic strategies for this cancer.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Long noncoding RNA CASC9 promotes the proliferation and metastasis of papillary thyroid cancer via sponging miR‐488‐3p

Chen

Gao³

2020

Cancer Medicine

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Cancer susceptibility candidate 9 (CASC9) is a recently identified lncRNA that acted as a tumor promotor in diversified cancer types. However, its role in papillary thyroid cancer (PTC) remains unknown. The expression of CASC9 was measured in 52 human PTC tissues and PTC cell lines as well as their controls. The proliferation, migration, and invasion of PTC cells were determined after knockdown or overexpression of CASC9 to evaluate the effect of CASC9 on PTC cells. Also, the role of PTC tumorigenesis was confirmed in mice xenograft models. Additionally, the underlying mechanisms of CASC9 were further researched. We found that CASC9 expression was augmented in human PTC tissues and cells. Higher CASC9 expression was associated with large tumor size, advanced stage, or lymph node metastasis. Downregulation of CASC9 significantly attenuated the proliferative, migrative, and invasive abilities of PTC cells, and suppressed tumorigenesis in vivo. While overexpression of CASC9 elevated the proliferation, migration, and invasion of PTC cells. miR‐488‐3p expression was decreased, and ADAM9 level was increased in PTC tissues and cells. CASC9 expression was negatively related to miR‐488‐3p, but positively associated with ADAM9 expression in PTC tissues. Molecular mechanism analysis revealed that CASC9 functioned via sponging miR‐488‐3p to regulate ADAM9 expression, followed by activation of EGFR‐Akt signaling. In conclusion, lncRNA CASC9 promoted the malignant phenotypes of PTC via modulating miR‐488‐3p/ADAM9 pathway. This study may provide a novel therapeutic target for the treatment of PTC.

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“…Archived blocks of primary tumour tissue were obtained. The recruitment procedures and the exclusion criteria (62 samples were ruled out from this study) have been described in detail in our other study, and the current study group was consistent to that reported previously . The study included 723 patients.…”

Section: Methodsmentioning

confidence: 91%

“…Tumour‐nodes,‐metastases (TNM) staging was standardized postoperatively in accordance with the 7th edition of the classification of the Union for International Cancer Control (UICC), 2010 . As described in the literature, detailed reanalysis of the data allowed for the precise clinicopathological features to be diagnosed as pNx or Mx at the presentation stage and to be reclassified as 0 or 1 clinically, according to the TNM. All of the nonspecific or suspicious changes in stage pNx cases visualized on postoperative neck ultrasound (US) were verified via fine‐needle aspiration biopsy followed by measurement of thyroglobulin (Tg) concentration in the aspirate.…”

Section: Methodsmentioning

confidence: 99%

Response to therapy of papillary thyroid cancer of known BRAF status

Kowalska

Walczyk

Kowalik

et al. 2017

Clinical Endocrinology

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Increase in Papillary Thyroid Cancer Incidence Is Accompanied by Changes in the Frequency of theBRAF^V600EMutation: A Single-Institution Study

Abstract: The prevalence of the BRAF(V600E)mutation increased significantly in PTCs diagnosed in the authors' institution. Improved detection and several causative factors, most likely environmental and changes in iodine intake, may contribute to the increasing occurrence of TC.

Cited by 37 publications

References 37 publications

Nutritional and Environmental Factors in Thyroid Carcinogenesis

Nutritional and Environmental Factors in Thyroid Carcinogenesis

RETRACTED: Long noncoding RNA CASC9 promotes the proliferation and metastasis of papillary thyroid cancer via sponging miR‐488‐3p

Response to therapy of papillary thyroid cancer of known BRAF status

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Increase in Papillary Thyroid Cancer Incidence Is Accompanied by Changes in the Frequency of theBRAFV600EMutation: A Single-Institution Study

Abstract: The prevalence of the BRAF(V600E)mutation increased significantly in PTCs diagnosed in the authors' institution. Improved detection and several causative factors, most likely environmental and changes in iodine intake, may contribute to the increasing occurrence of TC.

Cited by 37 publications

References 37 publications

Nutritional and Environmental Factors in Thyroid Carcinogenesis

Nutritional and Environmental Factors in Thyroid Carcinogenesis

RETRACTED: Long noncoding RNA CASC9 promotes the proliferation and metastasis of papillary thyroid cancer via sponging miR‐488‐3p

Response to therapy of papillary thyroid cancer of known BRAF status

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Increase in Papillary Thyroid Cancer Incidence Is Accompanied by Changes in the Frequency of theBRAF^V600EMutation: A Single-Institution Study