Increase in platelet–large cell ratio in chronic myeloid leukemia

Kabutomori, Osamu; Kanakura, Yuzuru; Iwatani, Yoshinori

doi:10.1016/s0145-2126(01)00017-0

Cited by 9 publications

(10 citation statements)

References 2 publications

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“…In patients with CML, we found a markedly increased percentage of large platelets by measuring a parameter (P-LCR) of platelet volume by an automated analyzer, compared with patients with other CMPD or RT. The same result was found in our previous study [5]. The level of P-LCR in CML was markedly higher than in the other thrombocytosis-related diseases (PV, ET and RT).…”

Section: Discussionsupporting

confidence: 91%

“…In patients with CMPD (CML, ET and PV), there are often morphological abnormalities such as large platelets on blood smears [2, 5]. In patients with CML, we found a markedly increased percentage of large platelets by measuring a parameter (P-LCR) of platelet volume by an automated analyzer, compared with patients with other CMPD or RT.…”

Section: Discussionmentioning

confidence: 74%

“…Using these parameters, it has been demonstrated that RT and CMPD can be differentiated [4], but it remains impossible to differentiate 3 CMPD, that is, polycythemia vera (PV), essential thrombocythemia (ET) and chronic myeloid leukemia (CML). Although we clarified that P-LCR is higher in CML than in other CMPD (ET and PV) and RT [5], it remains impossible to differentiate RT, PV and ET. It is well known that serum levels of lactate dehydrogenase (LDH) increase in relation to cell destruction or necrosis [6] and the serum levels of CRP represent the presence of inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Characteristic Changes in Platelet-Large Cell Ratio, Lactate Dehydrogenase and C-Reactive Protein in Thrombocytosis-Related Diseases

2007

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We examined the clinical usefulness of 3 parameters of routine laboratory tests [platelet-large cell ratio (P-LCR), lactate dehydrogenase (LDH) and C-reactive protein (CRP)] in 84 patients with thrombocytosis-related diseases (reactive thrombocytosis, chronic myeloid leukemia, essential thrombocythemia and polycythemia vera). These thrombocytosis-related diseases were characterized using the 3 parameters P-LCR, LDH and CRP as follows: high P-LCR and high LDH in chronic myeloid leukemia; high CRP in reactive thrombocytosis; slightly high P-LCR and high LDH in essential thrombocythemia and polycythemia vera. For essential thrombocythemia and polycythemia vera, levels of P-LCR and CRP were nearly identical, but the LDH level in essential thrombocythemia was significantly higher than in polycythemia vera. These characteristics of P-LCR, LDH and CRP may be useful for simple and very rough differentiation of the thrombocytosis-related disease mentioned above.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 74%

Section: Introductionmentioning

confidence: 99%

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Characteristic Changes in Platelet-Large Cell Ratio, Lactate Dehydrogenase and C-Reactive Protein in Thrombocytosis-Related Diseases

2007

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“…In addition to marked granulocytic predominance, pathological and morphological findings show that the number of megakaryocytes in the chronic phase is frequently increased, and that these cells exhibit abnormal features (small with abnormal lobation) (2). Megakaryocytes are the source of platelet production, and dysmegakaryopoiesis implies dysregulated platelet production, involving dysmorphology (increased size, particularly giant platelets) (3,4), abnormal counts and impaired function (5)(6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Normal platelet counts mask abnormal thrombopoiesis in patients with chronic myeloid leukemia

et al. 2015

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Abstract. Increased platelet heterogeneity has been reported in myeloproliferative neoplasms (MPN) with thrombocytosis. However, whether abnormal thrombopoiesis occurs in patients with chronic myeloid leukemia (CML) who have normal platelet counts, remains unclear. In order to explore this question, 25 patients with CML with normal platelet counts (CML-N), 40 patients with CML with elevated platelet counts (CML-E) and 33 healthy adults were recruited. The association of platelet count with mean platelet volume (MPV), platelet large cell ratio (P-LCR) and platelet distribution width (PDW) was examined. Bone marrow smears were also reviewed to assess the proliferation and abnormal lobation of megakaryocytes. The results showed that the two CML groups exhibited higher MPV, P-LCR and PDW values than those of the controls (P<0.05). Furthermore, the CML-N group was more heterogeneous in terms of thrombopoiesis than the CML-E group, as demonstrated by a higher PDW (P<0.05) and higher ratio of multinucleated dysmegakaryocytes (12.17 vs. 4.69%; χ 2 =29.79; P=0.000). In addition, no correlation between platelet count and MPV, P-LCR or PDW was observed in the CML-N group (r=-0.102, -0.051 and -0.049, and P=0.619, 0.828 and 0.810, respectively). The results suggested that patients in the CML-N group have more heterogeneous thrombopoiesis of megakaryocytes and platelets, and that apparently normal platelet counts may mask the abnormal thrombopoiesis in these patients.

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“…Table 3. Correlation coefficients among platelet indices in 255 subjects studied 과 진성적혈구증가증 환자 모두 기준 이하였다 [21]. …”

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Evaluation of Platelet Indices for Differential Diagnosis of Thrombocytosis by ADVIA 120

et al. 2009

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Increase in platelet–large cell ratio in chronic myeloid leukemia

Cited by 9 publications

References 2 publications

Characteristic Changes in Platelet-Large Cell Ratio, Lactate Dehydrogenase and C-Reactive Protein in Thrombocytosis-Related Diseases

Characteristic Changes in Platelet-Large Cell Ratio, Lactate Dehydrogenase and C-Reactive Protein in Thrombocytosis-Related Diseases

Normal platelet counts mask abnormal thrombopoiesis in patients with chronic myeloid leukemia

Evaluation of Platelet Indices for Differential Diagnosis of Thrombocytosis by ADVIA 120

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