Increase in response and number of α-adrenoceptors of rat vas deferens on brief pretreatment with an α-agonist

Hata, Fumiaki; Uchida, Shuji; Yoshida, Hiroshi

doi:10.1016/0014-2999(80)90498-7

Cited by 21 publications

(4 citation statements)

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“…A few quantitative changes in a-adrenergic receptors under certain experimental conditions have also been reported (23)(24)(25). Previously, we observed rapid and functional increases in a-adrenergic receptors in rat vas deferens; short term exposure of vas deferens to a-agonists resulted in enhancement of the contractile response with increase in the number of a-receptors, measured quantitatively by (3H)WB4101 binding (26). In the present work we examined changes in the number of a-adrenergic receptors in rat brain induced by preincubation with a-agonists or a-antagonists.…”

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confidence: 57%

Changes in .ALPHA.-adrenergic receptors in rat brain in vitro by preincubation with .ALPHA.-adrenergic ligands.

et al. 1980

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confidence: 57%

Changes in .ALPHA.-adrenergic receptors in rat brain in vitro by preincubation with .ALPHA.-adrenergic ligands.

et al. 1980

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“…The contractile response of rat vas deferens to adrenaline is enhanced by prior exposure to the same agent. In this particular experiment, an increase in the number of a-receptors as well as an enhancement of maximal response to adrenaline was observed (Hata et al, 1980). The mechanism involved in these effects is not known.…”

Section: Modulation Ofreceptor Sensitivitymentioning

confidence: 69%

Biochemical pharmacology of paradoxical sleep.

Gaillard¹

1983

Brit J Clinical Pharma

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1 The role of noradrenergic cells in the regulation of paradoxical sleep is still controversial, and experimental data have given rise to contradictory interpretations.2 Early investigations focused primarily on chemical neurotransmissions. However, the process of information transmission between cells involves many other factors, and the cell surface is an important site for transduction of messages into modifications of the activity of postsynaptic cells.3 a-adrenoceptors are believed to play an important role in the control of wakefulness and paradoxical sleep. Experimental evidence suggests that physiological modulation of receptor sensitivity, possibly by specific neuro-modulators, may be a key mechanism in synaptic transmission. 4 In the investigation of the mechanisms involved in paradoxical sleep regulation, lesions of the locus coeruleus have given equivocal results. Collateral inhibition, probably mediated by a2-adrenoceptors, appears to be a powerful mechanism. The exact temporal relationship between noradrenergic cell activation and paradoxical sleep production is not established, but 5-HT appears to be involved. Differences between paradoxical sleep and waking may be related to a physiological modulation of a2-adrenoceptor sensitivity.

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“…In contrast, Hata et al (1980) have reported an increased maximum contraction with no change in sensitivity of rat vas deferens after exposure to epinephrine for 10 min at 20°C, which was associated with an increase in the density of alpha-adrenergic receptors. We found that exposure of rat vas deferens or caudal arteries to high concentrations of norepinephrine for 3 h at 37°C significantly decreased contractile sensitivity of both tissues to phenylephrine, without changes in maximum contraction or the density or affinity of alpha-1 adrenergic receptors measured in binding assays .…”

Section: Time (Days)mentioning

confidence: 77%

The alpha-1 Adrenergic Receptors

Ruffolo¹

1987

The Receptors

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All rights reservedNo part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise without written permission from the Publisher.Preface vii ology will allow alpha-l adrenergic receptors to be isolated and purified and their amino acid sequence to be identified. This will ultimately allow for the systematic subclassification of alpha-l adrenergic receptors and for their differential regulation to be studied in greater detail. These new advances are likely to take place within the next five years, and it is our intent for this review of alpha-l adrenergic receptor pharmacology to provide an accurate summary of the current state of knowledge relating to alpha-l adrenergic receptors, which we hope will serve as a foundation upon which to build a broader base of knowledge in the future.

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Increase in response and number of α-adrenoceptors of rat vas deferens on brief pretreatment with an α-agonist

Cited by 21 publications

References 18 publications

Changes in .ALPHA.-adrenergic receptors in rat brain in vitro by preincubation with .ALPHA.-adrenergic ligands.

Changes in .ALPHA.-adrenergic receptors in rat brain in vitro by preincubation with .ALPHA.-adrenergic ligands.

Biochemical pharmacology of paradoxical sleep.

The alpha-1 Adrenergic Receptors

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