Increase of HCN current in SOD1-associated amyotrophic lateral sclerosis
Hsing-Jung Lai,
Yih-Chih Kuo,
Chen-Hung Ting
et al.
Abstract:The clinical manifestations of sporadic amyotrophic lateral sclerosis (ALS) vary widely. However, the current classification of ALS is mainly based on clinical presentations, while the roles of electrophysiological and biomedical biomarkers remain limited. Herein, we investigated a group of patients with sporadic ALS and an ALS mouse model with superoxide dismutase 1 (SOD1)/G93A transgenes using nerve excitability tests (NET) to investigate axonal membrane properties and chemical precipitation, followed by enz… Show more
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