Increase resistant rates and ESBL production between E. coli isolates causing urinary tract infection in young patients from Iran

Abstract

Emerging antimicrobial resistance rates and Extended-spectrum beta-lactamase producing Escherichia coli recovered from urinary tract infections (UTI) is an increasing problem in specific regions, limiting therapeutic options. One hundred E. coli isolates causing UTI in patients with age from 2 months to 12 years admitted at CMC in the period of April 2009 to March 2010 were tested for antibiotic susceptibility using the disk diffusion method. Surprisingly high resistance rates were recorded for E. coli against TMP/SMX (84%), cefalotin (66%), cefuroxime (50%), cefixime (50%) and ceftriaxone (45%). Antimicrobial susceptibility of E. coli isolates was followed by meropenem (98%), amikacin (95%), nitrofurantoin (91%) and gentamicin (68%). Extended spectrum beta-lactamase production, was observed in 32% of community and 42% of nosocomial isolates. The results of this study and numerous observations regarding the increasing resistance to these antibiotics, in several countries, emphasize the need for local population-specific surveillance for guiding empirical therapy for UTI in children.

High Microbiological Spectrum Resistance Rates in urine isolates from Jalisco, Mexico. A retrospective study and literature review

“…For example, the practice in México was to sell antimicrobials over-the-counter until 2010, at which time physician prescriptions became a requirement. Importantly, some studies have identified international travel as a risk factor for the colonization by and infection with resistant E. coli [6,22,28]. This finding highlights the importance of recognizing resistance patterns in different parts of the world, particularly in places where tourism attracts many international travelers.…”

“…ESBL are beta-lactamases that hydrolyze extended spectrum cephalosporins with an oxyimino side chain [6]. Community acquisition of ESBLproducing E. coli was first reported in Ireland in 1998, where an ESBL producing nalidixic acidresistant uropathogenic E. coli strain was isolated from an elderly patient who did not have a recent history of hospitalization.…”

“…UTIs have been reported to affect up to 150 million individuals annually worldwide [1][2][3] and contribute to >30% of health-care facility associated infections, as annually reported by acute care hospitals [4]. UTIs are one of the most common bacterial infections occurring in children and the most common bacterial infection diagnosed in women [2,5,6]. Prompt recognition and correct antimicrobial management can relieve symptoms and prevent more serious sequelae, such as progressive kidney damage [5,6].…”

“…UTIs are one of the most common bacterial infections occurring in children and the most common bacterial infection diagnosed in women [2,5,6]. Prompt recognition and correct antimicrobial management can relieve symptoms and prevent more serious sequelae, such as progressive kidney damage [5,6]. Most UTIs (85%) are caused by Escherichia coli (E. Coli) and Staphylococcus saprophyticus (10%), with Klebsiella pneumoniae and the Proteus species accounting for the majority of the remaining etiologic agents [1].…”

Bacterial Aetiology and Antibiotic Resistance Pattern of Community-Acquired Urinary Tract Infections in Children in a Tertiary Care Hospital in Bangladesh

“…are rarely encountered in cases of community-acquired UTI in several other studies. 9,25 But, in a study by Akram et al 17 in India higher prevalence (27.3%) of Klebsiella spp. was found.…”