Increased acute blood flow induced by the aqueous extract of Euterpe oleracea Mart. fruit pulp in rats in vivo is not related to the direct activation of endothelial cells

Pontes, Victória Caroline Bottino; Tavares, Juliana Pereira Tavares de Melo; Rosenstock, Tatiana R.; Rodrigues, Domingos Sávio; Yudi, Marcelo Icimoto; Soares, Jaqueline Pereira Moura; Ribeiro, Suzana Costa; Sutti, Rafael; Torres, Luce Maria Brandão; Melo, Fabiana Henriques Machado de; Gamberini, Maria Thereza

doi:10.1016/j.jep.2021.113885

Cited by 4 publications

(3 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cardiovascular disease and gastrointestinal disorders are top two major aging-associated health conditions that have greater decrements impact on functioning and well-being [77]. Because the contract and relaxation of the muscles lining the intestines to move food along the digestive tract can be weakened by venous thromboembolism (VTE) and by ischemic colitis that result in intermittent abdominal pain/discomfort, altered bowel patterns, and abdominal bloating/distension [6] and because the key active ingredients of ColonVita such as acai extract can improve blood flow in rats [40], reduce inflammatory response in macrophage cells [41], and reduce hepatic oxidative stress of dams fed high-fat diet and increases antioxidant enzymes' gene expression in the offspring [42], future studies should determine if the selective effectiveness of ColonVita on GIQLI in CVD-free subpopulation is unique to ColonVita or it is a general mechanism of dietary supplement rich in anti-inflammatory and antihemostasis potentials.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Relieving Effects of a Polyherb-Based Dietary Supplement ColonVita on Gastrointestinal Quality of Life Index (GIQLI) in Older Adults with Chronic Gastrointestinal Symptoms Are Influenced by Age and Cardiovascular Disease: A 12-Week Randomized Placebo-Controlled Trial

Xing

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Chronic gastrointestinal symptoms (CGS) negatively affect the quality of life in about 15–30% of the population without effective drugs. Recent studies suggest that dietary supplement may improve CGS, but inconsistent results exist. The goal of this study is to evaluate the effect of a polyherbal-based supplement ColonVita on the gastrointestinal quality of life index (GIQLI) in 100 old adults with CGS (63.1 ± 9.6 years) who were randomly assigned to daily ColonVita or placebo tablets (n = 50/group) for 12 weeks in a double-blind, randomized controlled trial design. No significant fibrdifferences were found between ColonVita and placebo in the baseline total GIQLI score (101.12 ± 16.87 vs. 101.80 ± 16.48) ( P > 0.05 ) or postintervention total GIQLI score (114.78 ± 9.62 vs. 111.74 ± 13.01) ( P > 0.05 ). However, ColonVita significantly improved 16 scores of the 19 core GI symptoms compared with 10 items improved by placebo. The ColonVita group significantly improved the remission rate of 5 core GI symptoms compared to placebo and significantly improved the total GIQLI scores (118.09 ± 7.88 vs. 109.50 ± 16.71) ( P < 0.05 ) and core GI symptom scores (64.61 ± 3.99 vs. 60.00 ± 8.65) ( P < 0.05 ) in people ≥60 years of age (n = 49) but not in those under 60 y (n = 51). ColonVita significantly improved the total GIQLI scores and core GI symptom scores in people without cardiovascular diseases (CVD) (n = 56) (116.74 ± 9.38 vs. 110.10 ± 14.28) ( P < 0.05 ) and (63.11 ± 4.53 vs. 59.93 ± 8.03) ( P = 0.07 ), respectively, but not in those with CVD (n = 44). Thus, ColonVita was beneficial for old adults with CGS, especially those ≥60 years of age and without CVD. Because a heterogenous pathogenesis of CGS-like irritable bowel syndrome (IBS) and inflammatory bowel disease (ISD) is differentially associated with CVD, different comorbidities may have influenced the outcomes of different trials that should be controlled in further studies.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Acai promotes jejunal tissue regeneration by enhancing the antioxidant response in 5-fluorouracil-induced mucositis [39]. Aqueous extract of acai increases blood flow acutely in rats [40]. Acai reduces the inflammatory response induced by antipsychotic drug olanzapine in macrophage cells [41].…”

Section: Introductionmentioning

confidence: 99%

The Relieving Effects of a Polyherb-Based Dietary Supplement ColonVita on Gastrointestinal Quality of Life Index (GIQLI) in Older Adults with Chronic Gastrointestinal Symptoms Are Influenced by Age and Cardiovascular Disease: A 12-Week Randomized Placebo-Controlled Trial

Xing

Zhang

et al. 2021

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Pontes et al [ 122 ] demonstrated that the treatment of male Wistar rats with intravenous aqueous açaí pulp extract intravenously resulted in acutely elevated levels of blood flow. Mathias et al [ 123 ] also found that supplementation with açaí pulp reduced left ventricular dysfunction, oxidative stress, changes in the myocardium metabolism, and metalloproteinases activation in rat models of cardiac remodeling.…”

Section: Biological and Pharmacological Effectsmentioning

confidence: 99%

Açaí (Euterpe oleracea Mart.) in Health and Disease: A Critical Review

et al. 2023

View full text Add to dashboard Cite

The açaí palm (Euterpe oleracea Mart.), a species belonging to the Arecaceae family, has been cultivated for thousands of years in tropical Central and South America as a multipurpose dietary plant. The recent introduction of açaí fruit and its nutritional and healing qualities to regions outside its origin has rapidly expanded global demand for açaí berry. The health-promoting and disease-preventing properties of this plant are attributed to numerous bioactive phenolic compounds present in the leaf, pulp, fruit, skin, and seeds. The purpose of this review is to present an up-to-date, comprehensive, and critical evaluation of the health benefits of açaí and its phytochemicals with a special focus on cellular and molecular mechanisms of action. In vitro and in vivo studies showed that açaí possesses antioxidant and anti-inflammatory properties and exerts cardioprotective, gastroprotective, hepatoprotective, neuroprotective, renoprotective, antilipidemic, antidiabetic, and antineoplastic activities. Moreover, clinical trials have suggested that açaí can protect against metabolic stress induced by oxidation, inflammation, vascular abnormalities, and physical exertion. Due to its medicinal properties and the absence of undesirable effects, açaí shows a promising future in health promotion and disease prevention, in addition to a vast economic potential in the food and cosmetic industries.

show abstract

Dopaminergic, cholinergic and nitrinergic pathways implicated in blood pressure lowering effects of Saccharum officinarum L. (Sugarcane) on rats.

et al. 2022

View full text Add to dashboard Cite

Increased acute blood flow induced by the aqueous extract of Euterpe oleracea Mart. fruit pulp in rats in vivo is not related to the direct activation of endothelial cells

Cited by 4 publications

References 47 publications

The Relieving Effects of a Polyherb-Based Dietary Supplement ColonVita on Gastrointestinal Quality of Life Index (GIQLI) in Older Adults with Chronic Gastrointestinal Symptoms Are Influenced by Age and Cardiovascular Disease: A 12-Week Randomized Placebo-Controlled Trial

The Relieving Effects of a Polyherb-Based Dietary Supplement ColonVita on Gastrointestinal Quality of Life Index (GIQLI) in Older Adults with Chronic Gastrointestinal Symptoms Are Influenced by Age and Cardiovascular Disease: A 12-Week Randomized Placebo-Controlled Trial

Açaí (Euterpe oleracea Mart.) in Health and Disease: A Critical Review

Dopaminergic, cholinergic and nitrinergic pathways implicated in blood pressure lowering effects of Saccharum officinarum L. (Sugarcane) on rats.

Contact Info

Product

Resources

About