Increased AIF-1-mediated TNF-α expression during implantation phase in IVF cycles with GnRH antagonist protocol

Xu, Bufang; Zhou, Mingjuan; Wang, Jingwen; Zhang, Dan; Guo, Feng; Si, Chenchen; Leung, Peter C.K.; Zhang, Aijun

doi:10.1093/humrep/dey119

Cited by 30 publications

(27 citation statements)

References 32 publications

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“…Accordingly, the number of pregnancies in the Fluoxetine group was twice as many as that in the control group and also an increase in TNF-α did not affect the pregnancy rate. Unlike our results, the findings of the studies done by Xu et al (2018) and Boudjenah et al (2014) showed that an increase in the TNF-α serum levels caused disorders in the embryo implantation, as a result of which there was a decrease in pregnancy rate during IVF 36,37 . According to Lee et al, an increase in the TNF-α level decreases the quality, but not the number of oocytes and there is no relationship between its level and pregnancy 8 .…”

Section: Discussioncontrasting

confidence: 99%

The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women

Keshavarz

Behbahani

Parsanezhad

et al. 2020

Arch. Clin. Psychiatry (São Paulo)

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Objectives: This study aimed to explore the effect of antidepressant treatment on the HPA axis, changes in depression score, and serum levels of TNF-α in depressed infertile women. Methods: In this randomized controlled trial research, 60 infertile women who had undergone in vitro fertilization (IVF) treatment with depression scores between 16-47 were divided into two groups. The intervention group with fluoxetine capsule was under treatment for two months before the embryo transfer, while the control group was given placebo. Depression score, serum levels of tumor necrosis factor alpha (TNF-α) as well as cortisol hormone levels were measured and recorded both before and after the intervention. The data were analyzed using SPSS version 21 software. Results: We analyzed the data related to 55 subjects who had undergone embryo transfer. 7 subjects in the intervention group and 3 in the control group got pregnant. We observed a significant decrease in the depression score (p < 0/001) and serum levels of cortisol (p = 0/001) in the intervention group. There was a significant increase in the serum levels of TNF-α in the intervention group (p < 0/001). There was a significant difference between the two groups in the number of pregnancies (p = 0.04). However, there was no statistical difference between them with regard to the number of harvested oocytes (p = 0.174). Discussion: Decrease in depression score and cortisol level, and an increase in the levels of TNF-α in the intervention group caused any changes in the number of oocytes in comparison with the control group. However, the number of pregnancies was larger in the intervention group.

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Section: Discussioncontrasting

confidence: 99%

The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women

Keshavarz

Behbahani

Parsanezhad

et al. 2020

Arch. Clin. Psychiatry (São Paulo)

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“…RL95-2 cells were cultured in 35-mm plates (3 × 10 5 cells) and grown with the transfected GLUT1 siRNA or NC treatments. JAR cells were pretreated with diluted (0.5 mM) CellTrace ™ CFSE (Invitrogen, Carlsbad, CA, United States) medium for 30 min, and the cells suspension was added to plates containing RL95-2 cell monolayer, which were gently shaken (40 rpm) 1 h at 37°C (Choi et al, 2017;Xu et al, 2018). Then, the cell culture supernatant was removed, the plates were washed with PBS, the images were acquired using a fluorescent microscope, and the number of attached cells were counted using Image-Pro Plus software (Media Cybernetics Inc., Silver Spring, MD, United States).…”

Section: In Vitro Adhesion and Invasion Assaymentioning

confidence: 99%

Progesterone Regulates Glucose Metabolism Through Glucose Transporter 1 to Promote Endometrial Receptivity

et al. 2020

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Successful embryo implantation requires receptive endometrium, which is conducive to the process of embryo recognition, adhesion, and invasion within a certain period of time and is inseparable from the dynamic interaction between 17β-estradiol (E2) and progesterone (P4). Proper glucose metabolism is critical for the profound physiological changes in the endometrium entering the receptive state. And glucose transporters (GLUTs) are responsible for intracellular uptake of glucose and are the first step in glucose metabolism. Prior literature has reported the presence of GLUTs in the endometrium. However, we still do not understand the specific mechanisms of this process. In this study, we identified the effect of P4 on glucose transporter 1 (GLUT1) using in vivo animal models and determined the regulation of glucose metabolism by P4 in cells. We highly suspect that this pregnancy failure may be due to reduced GLUT1-mediated glucose metabolism, resulting in a decrease in endometrial receptivity caused by an inadequate energy supply and synthesis of substrate. Here, we propose a possible mechanism to explain how embryo implantation is affected by P4 and glucose utilization under abnormal endometrial conditions.

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“…Tubal factor infertility cases caused by hydrosalpinx, salpingitis, etc., were excluded. The inclusion and exclusion criteria for both groups were the same as described previously (Guo et al, 2018;Xu et al, 2018). In addition, for the isolation of primary EECs and ESCs, another Data presented as mean ± SD or frequency.…”

Section: Participants and Endometrial Biopsiesmentioning

confidence: 99%

“…The human EEC line Ishikawa was obtained from European Collection of Authenticated Cell Cultures (ECACC), and were authenticated by DNA profiling using short tandem repeat (STR) analysis (Supplementary Figure S1A) and mycoplasma free (Supplementary Figure S1B). Isolation of primary human EECs and ESCs was performed as previously described (Xu et al, 2018) . Briefly, endometrial biopsy samples were processed within 4 h of collection.…”

Section: Cell Culturementioning

confidence: 99%

Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity

Zhou

Zhang

et al. 2020

Front. Cell Dev. Biol.

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Increased AIF-1-mediated TNF-α expression during implantation phase in IVF cycles with GnRH antagonist protocol

Cited by 30 publications

References 32 publications

The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women

The effect of antidepressant treatment on the HPA axis, changes in depression score and serum levels of TNF-α in depressed infertile women

Progesterone Regulates Glucose Metabolism Through Glucose Transporter 1 to Promote Endometrial Receptivity

Loss of CDYL Results in Suppression of CTNNB1 and Decreased Endometrial Receptivity

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