Increased allostatic load associated with ambient air pollution acting as a stressor: Cross-sectional evidence from the China multi-ethnic cohort study

Xu, Huan; Yang, Tingting; Guo, Bing; Silang, Yangzong; Dai, Yue; Baima, Kangzhuo; Gao, Yang; Tang, Simei; Wei, Jing; Jiang, Ye; Feng, Shiyu; Li, Sicheng; Xiao, Xiong; Zhao, Xing

doi:10.1016/j.scitotenv.2022.155658

Cited by 7 publications

(3 citation statements)

References 71 publications

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“…Inverse probability weighting was further used in this study to control for confounding bias. Since the exposure was a continuous variable, a generalized propensity score model was first constructed ( 47 , 48 ), with the exposure as the dependent variable and the confounding covariates as independent variables. To account for survey weights, we also incorporated them as covariates, following suggestions from the literature ( 49 ).…”

Section: Methodsmentioning

confidence: 99%

Association of waist circumference and BMI with premature death in young and middle-aged population

Hu,

Han,

Chen

et al. 2024

Front. Public Health

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IntroductionPremature death is a global health indicator, significantly impacted by obesity, especially in young and middle-aged population. Both body mass index (BMI) and waist circumference (WC) assess obesity, with WC specifically indicating central obesity and showing a stronger relationship with mortality. However, despite known associations between BMI and premature death, as well as the well-recognized correlation between WC and adverse health outcomes, the specific relationship between WC and premature death remains unclear. Therefore, focusing on young and middle-aged individuals, this study aimed to reliably estimate independent and combined associations between WC, BMI and premature death, thereby providing causal evidence to support strategies for obesity management.MethodsThis study involved 49,217 subjects aged 18–50 years in the United States from 1999 to 2018 National Health and Nutrition Examination Survey (NHANES). Independent and combined associations between WC and BMI with premature death across sex and age stratum were examined by Cox regression. Survey weighting and inverse probability weighting (IPW) were further considered to control selection and confounding bias. Robustness assessment has been conducted on both NHANES and China Health and Retirement Longitudinal Study (CHARLS) data.ResultsA linear and positive relationship between WC and all-cause premature death was found in both males and females, with adjusted HRs of 1.019 (95%CI = 1.004–1.034) and 1.065 (95%CI = 1.039–1.091), respectively. Nonlinear relationships were found with respect to BMI and all-cause premature death. For females aged 36–50 with a BMI below 28.6 kg/m2, the risk of premature death decreased as BMI increased, indicated by adjusted HRs of 0.856 (95%CI = 0.790–0.927). Joint analysis showed among people living with obesity, a larger WC increased premature death risk (HR = 1.924, 95%CI = 1.444–2.564).DiscussionWC and BMI exhibited prominent associations with premature death in young and middle-aged population. Maintaining an appropriate WC and BMI bears significant implications for preventing premature death.

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Section: Methodsmentioning

confidence: 99%

Association of waist circumference and BMI with premature death in young and middle-aged population

Hu,

Han,

Chen

et al. 2024

Front. Public Health

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“…113 There is growing evidence that allostatic load increases with increasing exposure to air pollution, offering a potential way to assess cumulative impacts of the overall burden of stressor experienced. 114,115 Prior experimental studies have demonstrated that circadian genes ranked among the top differentially expressed genes in response to air pollution exposure. 116 Mice exposed to concentrated ambient PM 2.5 demonstrated insulin resistance, reduced energy expenditure, metabolism, thermogenesis, and dysregulated circadian genes, which reversed with cessation.…”

Section: Allostatic Load In Response To Environmental Stressorsmentioning

confidence: 99%

Understanding the Cardiovascular and Metabolic Health Effects of Air Pollution in the Context of Cumulative Exposomic Impacts

Khraishah,

Chen,

Rajagopalan

2024

Circulation Research

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Poor air quality accounts for more than 9 million deaths a year globally according to recent estimates. A large portion of these deaths are attributable to cardiovascular causes, with evidence indicating that air pollution may also play an important role in the genesis of key cardiometabolic risk factors. Air pollution is not experienced in isolation but is part of a complex system, influenced by a host of other external environmental exposures, and interacting with intrinsic biologic factors and susceptibility to ultimately determine cardiovascular and metabolic outcomes. Given that the same fossil fuel emission sources that cause climate change also result in air pollution, there is a need for robust approaches that can not only limit climate change but also eliminate air pollution health effects, with an emphasis of protecting the most susceptible but also targeting interventions at the most vulnerable populations. In this review, we summarize the current state of epidemiologic and mechanistic evidence underpinning the association of air pollution with cardiometabolic disease and how complex interactions with other exposures and individual characteristics may modify these associations. We identify gaps in the current literature and suggest emerging approaches for policy makers to holistically approach cardiometabolic health risk and impact assessment.

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“…One study [40], completed in CN, utilized AOD-PM10 (72.6 μg/m 3 ), AOD-PM2.5 (41.8 μg/m 3 ), and AOD-PM1 (27.6 μg/m 3 ) to document observed changes to ALSspecific outcomes. There were significantly positive associations between ALS and AOD-PM10 and AOD-PM2.5.…”

Section: Allostatic Load (Als)mentioning

confidence: 99%

Inflammation Describes and Explains the Adverse Effects of Aerosol Optical Depth-Particulate Matter on Cardiovascular Outcomes: A Literature Review Since 2012

Braggio

2023

MRAJ

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The success of remote sensing methodology to accurately estimate ambient particulate matter (PM) on the earth’s surface has resulted in the increased use of aerosol optical depth (AOD) AOD-PM 10 , AOD-PM 2.5 and AOD-PM 1 concentration level fused surfaces in cardiovascular epidemiologic and hypothesis-testing of inflammatory physiologic studies. Uniform space-time AOD-PM concentration level fused surfaces have been used as proxies for ambient PM monitor measurements in economically developed and developing counties as well as in densely populated urban regions with on-the-ground ambient PM monitors and in sparsely populated rural areas without ambient PM air monitors to determine the contribution of PM exposure to the subsequent occurrence of cardiovascular chronic diseases and circulatory-related adverse health outcomes. Since 2012, 45 published studies have evaluated the association between increased AOD-PM concentration level readings and adverse cardiovascular outcomes. Fifteen surveillance studies used inflammation as a descriptive physiologic mechanism and another nine publications mentioned another description. In contrast, another 20 investigations have used the inflammatory physiologic mechanism to explain how AOD-PM exposure changes the cardiovascular system and other organs connected to the cardiovascular system through the circulatory system and one report referred to some other explanation. The full extent of the adverse effects of AOD-PM exposure on the cardiovascular system only becomes evident when cardiovascular and other pathophysiological changes are also considered and evaluated. This review paper aims to demonstrate why AOD-PM and cardiovascular system studies are a new and useful source of information about how ambient PM exposure adversely impacts the cardiovascular system in diverse populations in different countries.

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Increased allostatic load associated with ambient air pollution acting as a stressor: Cross-sectional evidence from the China multi-ethnic cohort study

Cited by 7 publications

References 71 publications

Association of waist circumference and BMI with premature death in young and middle-aged population

Association of waist circumference and BMI with premature death in young and middle-aged population

Understanding the Cardiovascular and Metabolic Health Effects of Air Pollution in the Context of Cumulative Exposomic Impacts

Inflammation Describes and Explains the Adverse Effects of Aerosol Optical Depth-Particulate Matter on Cardiovascular Outcomes: A Literature Review Since 2012

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