Increased blood plasma hydrolysis of acetylsalicylic acid in type 2 diabetic patients: A role of plasma esterases

Grešner, Peter; Dolnik, Martin; Waczulíková, Iveta; Bryszewska, Maria; Šikurová, L; Watała, Cezary

doi:10.1016/j.bbagen.2005.11.018

Cited by 37 publications

(31 citation statements)

References 37 publications

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“…We could speculate an increased activity of esterases in diabetic patients, which would convert more of the clopidogrel pro-drug into inactive metabolite. This has been seen for aspirin resistance, in which increased activity of plasma esterases hydrolyzed acetylsalicylic acid to a higher extent in Erlinge et al December 9, 2008December 9, :1968 Thienopyridine Responders patients with type 2 diabetes (34). Another possibility is that reduced gastric motility in diabetic patients could lead to slower absorption of the pro-drugs or that alterations at the megakaryocyte level changes platelet turnover and receptor expression.…”

Section: Discussionmentioning

confidence: 92%

Patients With Poor Responsiveness to Thienopyridine Treatment or With Diabetes Have Lower Levels of Circulating Active Metabolite, but Their Platelets Respond Normally to Active Metabolite Added Ex Vivo

Erlinge

Varenhorst

Braun

et al. 2008

Journal of the American College of Cardiology

196

135

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Section: Discussionmentioning

confidence: 92%

Patients With Poor Responsiveness to Thienopyridine Treatment or With Diabetes Have Lower Levels of Circulating Active Metabolite, but Their Platelets Respond Normally to Active Metabolite Added Ex Vivo

Erlinge

Varenhorst

Braun

et al. 2008

Journal of the American College of Cardiology

196

135

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“…Under conditions of our experiment, the BLMs composed of pure phosphatidylcholine are in the gel state, and their enrichment in cholesterol has a stabilizing effect due to clustering of the sterol within the phosphatidylcholine lipid core [11][12][13]18,21,23,24,[30][31][32][33][34]. ASA is known to spontaneously decompose (hydrolyze) into acetate and SA, although this process is relatively slow and takes 5-6 hours [35]. Xiang and Anderson [36] studied the permeability of acetic acid through the dipalmitoylphosphatidylcholine/cholesterol, dihexadecylphosphatidylcholine/cholesterol, or dimyristoylphosphatidylcholine/cholesterol vesicles using an NMR and found that the addition of cholesterol significantly reduced permeability of vesicles to acetic acid in both ordered and disordered liquid crystalline phases.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

Effect of acetylsalicylic acid on the current–voltage characteristics of planar lipid membranes

Watała

Drapeza²,

Loban³

et al. 2009

Biophysical Chemistry

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This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. contributed to the formation of metastable single pores, which facilitated ASA diffusion through a bilayer. Our data point out that ASA transport across the lipid bilayer takes place predominantly via the process of passive diffusion. In conclusion, the effects of ASA on lipid bilayer stability may contribute to drug transport through membrane lipid bilayers. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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“…This is in agreement with previous results reported in a population of type 2 diabetic patients. 14 The mechanism is not clear and should be the subject of further research. As expected, a stronger correlation was found between AE and ChE, a fact previously reported in other conditions and in control subjects.…”

Section: Discussionmentioning

confidence: 99%

Serum aspirin esterase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after haemodialysis

Gugliucci

Kotani

Kinugasa³

et al. 2010

Ann Clin Biochem

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Background: Studies regarding aspirin metabolism can be important in patients with renal failure who have an increased risk of cardiovascular diseases. We undertook this study to assess the aspirin esterase (AE) status in end-stage renal disease (ESRD) patients. Methods: A total of 42 patients on long-term haemodialysis (HD) with a mean dialysis course of 6.1 y were recruited. Results: Serum AE levels were 44% lower and cholinesterase (ChE) levels were 22% lower in ESRD patients before dialysis as compared with control subjects (P ¼ 0.0001). A very strong correlation was found between AE and ChE levels. AE levels increased on average 28% after dialysis with adjustments for age, gender, total cholesterol, triglyceride and high-density lipoprotein cholesterol (P ¼ 0.002). In addition, ChE levels were significantly increased (48%) after dialysis (P ¼ 0.0001). Changes in AE activity were significantly and positively correlated with those of ChE (r ¼ 0.427, P ¼ 0.005). When we adjusted for several confounders, we found that the changes in AE activity operated by dialysis are significant independently of age, gender, aspirin (ASA) intake, cholesterol, triglycerides, high-density lipoprotein cholesterol and ChE. Conclusions: We report that serum AE activity is significantly lower in ESRD and that treatment by HD results in an increase of activity. We confirm that AE is associated with lipid parameters and ChE. Our results show variations in ASA catabolism between the dialysis sessions, suggesting an oscillating pattern in ASA disposal in these patients. The mechanisms for reduced AE activity in uraemia and the effects of HD need further investigation.

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Increased blood plasma hydrolysis of acetylsalicylic acid in type 2 diabetic patients: A role of plasma esterases

Cited by 37 publications

References 37 publications

Patients With Poor Responsiveness to Thienopyridine Treatment or With Diabetes Have Lower Levels of Circulating Active Metabolite, but Their Platelets Respond Normally to Active Metabolite Added Ex Vivo

Patients With Poor Responsiveness to Thienopyridine Treatment or With Diabetes Have Lower Levels of Circulating Active Metabolite, but Their Platelets Respond Normally to Active Metabolite Added Ex Vivo

Effect of acetylsalicylic acid on the current–voltage characteristics of planar lipid membranes

Serum aspirin esterase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after haemodialysis

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