Increased body weight and improved quality of life in AIDS patients following V-1 Immunitor administration

Jirathitikal, Vichai; Metadilogkul, Orapun; Bourinbaiar, A S

doi:10.1038/sj.ejcn.1601756

Cited by 14 publications

(10 citation statements)

References 31 publications

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“…This could be explained probably due to lack of appropriate counseling of the patients. (Jirathitikal et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Nutritional Status and Quality of Life of Women with HIV/AIDS

S.¹

2012

American Journal of Infectious Diseases

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Problem statement:HIV infection is a multisystem disorder which causes chronic infections that lead to profound immune-suppression. Women have always been a vulnerable section of the society. They are doubly vulnerable due to the HIV and malnutrition vicious cycle, which may affect their Quality Of Life (QOL). There are different literature reviews which suggest undernutrition, wasting due to HIV but it is important to know whether this under-nutrition affects their Quality Of Life (QOL) of these vulnerable women. Approach: This cross sectional study recruited female patients on antiretroviral therapy. Weight, height, grip strength, Tricep Skin Fold (TSF) and Mid Upper Arm Circumference (MUAC) were measured. Nutrient intake was calculated by 24 h recall and food frequency questionnaire. WHO QOL-HIV BREF was used to assess QOL. Results: Among 55 patients, 32 (58.2%), 23 (41.8%) were asymptomatic and symptomatic respectively. The mean adequacies of energy and protein for all the subjects were 57.56 ± 21.89, 61.27 ± 28.50 percent respectively. The Body Mass Index (BMI) of the symptomatic were significantly (p = 0.009) lower than the asymptomatic subjects, the mean being 19.84 ± 3.6 (kg/m²), with 27.3% having BMI < 18.5 (kg/m²). The mean TSF, MUAC, grip strength and hemoglobin level were 10.66 ± 4.36 mm, 23.72 ± 3.43 cm, 16.12 ± 5.03 kg force and 10.8 ± 1.3g/dl respectively. The scores of QOL were correlated positively with all the parameters of nutritional status. Grip strength and hemoglobin level were significantly correlated (p = 0.01) with the scores of four and five domains of QOL respectively. Conclusion: Dietary intake was inadequate, which affected the nutritional status. Conservation of muscle mass and maintenance of hemoglobin levels may improve QOL in HIV infected women. Thus there is a need for nutritional counseling and other nutritional intervention.

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“…This could be explained probably due to lack of appropriate counseling of the patients. (Jirathitikal et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

Nutritional Status and Quality of Life of Women with HIV/AIDS

S.¹

2012

American Journal of Infectious Diseases

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“…It is also of interest that, in general, patients who are on a V1 regimen rarely develop new fungal or bacterial infections, suggesting that oral delivery of the vaccine restores the mucosal immune response to opportunistic infections. For example, the reduction or clearance of oral thrush was observed in 87.5% of patients (22). Finally, V1 therapy leads to a significant decrease in mortality due to AIDS.…”

Section: V-1 Immunitor (V1)mentioning

confidence: 97%

“…As of today over 65,000 AIDS patients in more than 60 countries have benefited from a daily oral dose of V1 (20). In a longitudinal survey of health status in 400 patients, about 85% reported subjective improvement after V1 treatment, 6% reported no difference, and 9% of patients reported minor adverse reactions, which did not last more than 1 week (22).…”

Section: V-1 Immunitor (V1)mentioning

confidence: 97%

Mucosal AIDS Vaccines

Bourinbaiar¹,

Metadilogkul

Jirathitikal³

2003

Viral Immunology

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Debates are still being waged over what is the best strategy for developing a potent AIDS vaccine. All the obvious approaches to making AIDS vaccines have been tried in the past two decades without much success. It is clear that new thinking and a revision of prevailing dogmas needs to be in place if we really want a vaccine. Conventional envelope-based antibody-inducing vaccines do not appear to hold promise, and broadly-neutralizing antibodies are now being searched as an alternative to the failed approach with subunit vaccines. The current consensus is that cellular immune responses, especially those mediated by CD8 cytotoxic/suppressor (CTL) and CD4 helper T lymphocytes, are needed to control HIV. Vaccines capable of inducing cell-mediated responses are, therefore, considered critical for controlling the spread of HIV. DNA-based vaccines triggering CTL reaction are currently thought to be an answer, but will they fulfill the promise? In the following paragraphs, a critical assessment of the state of the art will be provided in an attempt to analyze what we know and still don't know. The focus of this review is primarily on mucosal vaccines-a relatively new area in AIDS research. The update on V-1 Immunitor, the first mucosal AIDS vaccine available commercially, is provided within this context. Some of the reviewed concepts may be disputable, but without departure from the uninspiring consensus no substantial progress in the AIDS vaccine field can be envisioned.

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“…The difference from other blood-derived vaccines in this category is that this particular vaccine is formulated as a pill to be taken orally, hence targeting mucosal immune response. AIDS patients treated with V1 displayed body weight gain, rise in T cell counts, decrease in viremia, serodeconversion, reduced incidence in opportunistic infections, and general clinical improvement [59][60][61][62][63][64][65][66][67]. V1-treated patients had also higher survival rate -a major clinical endpoint that has never been achieved in published therapeutic vaccine trials [68].…”

Section: New Embodiment For Rsa Immunotherapy: Therapeutic Aids Vaccinementioning

confidence: 99%

AIDS Vaccines and Reproductive Immunology

Bourinbaiar¹,

Jirathitikal²,

Silin³

et al. 2007

CIR

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It may appear that problems of reproductive immunology have little in common with issues of treatment and prevention of AIDS. However, the certain aspects of HIV immunopathogenesis are closely related to problems faced by reproductive immunologists. The development of prophylactic and therapeutic AIDS vaccines would greatly benefit from acquired experience in immune regulation of reproductive dysfunction. The spermatozoa and HIV are foreign intruders that must enter the host cell, oocyte or T-lymphocyte, in order to start the replication process. The immune responses of the host organism against fertilized egg or HIV-impregnated lymphocyte must be similar, since in theory they are directed against alloantigens presented by such cells. This paper attempts to bring together the recent advances in AIDS field with progress made in the physiology and pathology of reproduction in humans, especially in the domain of immunotherapy and prevention of recurrent spontaneous abortions (RSA). It is our opinion that the lessons learned from alloimmunization trials of infertile women are relevant to prophylactic and therapeutic strategies for HIV infection.

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Increased body weight and improved quality of life in AIDS patients following V-1 Immunitor administration

Cited by 14 publications

References 31 publications

Nutritional Status and Quality of Life of Women with HIV/AIDS

Nutritional Status and Quality of Life of Women with HIV/AIDS

Mucosal AIDS Vaccines

AIDS Vaccines and Reproductive Immunology

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