Increased Brain-Derived Neurotrophic Factor and Hippocampal Dendritic Spine Density Are Associated with the Rapid Antidepressant-like Effect of Iron-citalopram and Iron-Imipramine Combinations in Mice

Kukuia, Kennedy Kwami Edem; Burns, Frederick Boakye; Adutwum-Ofosu, Kevin Kofi; Appiah, Frimpong; Amponsah, Seth Kwabena; Begyinah, Richard; Koomson, Awo Efua; Takyi, Ferka Yaw; Tagoe, Thomas Amatey; Amoateng, Patrick

doi:10.1016/j.neuroscience.2023.03.014

Cited by 3 publications

(4 citation statements)

References 82 publications

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Section: Role Of Bdnf-related Intracellular Signaling In Action Of An...mentioning

confidence: 97%

“…Furthermore, (2R,6R)-HNK treatment also reversed downregulation of BDNF, p-mTOR, and PSD95 observed in the PTSD rats ( Gou et al, 2023 ). Using female Institute of Cancer Research mice, it has been shown a synergistic antidepressant effect of iron co-applied with citalopram or imipramine ( Kukuia et al, 2023 ). Kukuia et al (2023) examined depression-like symptoms (by FST, tail suspension test, and open space swim test) when mice received the combination treatment of a sub-therapeutic dose of iron with classical antidepressants (citalopram or imipramine).…”

Section: Role Of Bdnf-related Intracellular Signaling In Action Of An...mentioning

confidence: 99%

“…Using female Institute of Cancer Research mice, it has been shown a synergistic antidepressant effect of iron co-applied with citalopram or imipramine ( Kukuia et al, 2023 ). Kukuia et al (2023) examined depression-like symptoms (by FST, tail suspension test, and open space swim test) when mice received the combination treatment of a sub-therapeutic dose of iron with classical antidepressants (citalopram or imipramine). It was revealed that the combination of iron with antidepressants achieved more rapid and superior antidepressant-like effect than the iron, citalopram or imipramine alone.…”

Section: Role Of Bdnf-related Intracellular Signaling In Action Of An...mentioning

confidence: 99%

“…Using female Institute of Cancer Research mice, it has been shown a synergistic antidepressant effect of iron co-applied with citalopram or imipramine (Kukuia et al, 2023). Kukuia et al (2023) Glucocorticoid stress and BDNF/TrkB system. Impairment of neuronal function associated with depression may be caused via the downregulation of BDNF/TrkB system and its downstream signaling (MAPK/ERK-, PLCγ-, PI3K/Akt-pathways) after the exposure to glucocorticoid stress.…”

Section: Role Of Bdnf-related Intracellular Signaling In Action Of An...mentioning

confidence: 99%

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Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

Numakawa,

Kajihara

2023

Front. Mol. Neurosci.

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Neurotrophins including brain-derived neurotrophic factor, BDNF, have critical roles in neuronal differentiation, cell survival, and synaptic function in the peripheral and central nervous system. It is well known that a variety of intracellular signaling stimulated by TrkB, a high-affinity receptor for BDNF, is involved in the physiological and pathological neuronal aspects via affecting cell viability, synaptic function, neurogenesis, and cognitive function. As expected, an alteration of the BDNF/TrkB system is suspected to be one of the molecular mechanisms underlying cognitive decline in cognitive diseases and mental disorders. Recent evidence has also highlighted a possible link between the alteration of TrkB signaling and chronic stress. Furthermore, it has been demonstrated that downregulation of the BDNF/TrkB system and chronic stress have a role in the pathogenesis of Alzheimer’s disease (AD) and mental disorders. In this review, we introduce current evidence showing a close relationship between the BDNF/TrkB system and the development of cognition impairment in stress-related disorders, and the possible contribution of the upregulation of the BDNF/TrkB system in a therapeutic approach against these brain diseases.

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Section: Role Of Bdnf-related Intracellular Signaling In Action Of An...mentioning

confidence: 97%

Section: Role Of Bdnf-related Intracellular Signaling In Action Of An...mentioning

confidence: 99%

Section: Role Of Bdnf-related Intracellular Signaling In Action Of An...mentioning

confidence: 99%

“…Using female Institute of Cancer Research mice, it has been shown a synergistic antidepressant effect of iron co-applied with citalopram or imipramine (Kukuia et al, 2023). Kukuia et al (2023) Glucocorticoid stress and BDNF/TrkB system. Impairment of neuronal function associated with depression may be caused via the downregulation of BDNF/TrkB system and its downstream signaling (MAPK/ERK-, PLCγ-, PI3K/Akt-pathways) after the exposure to glucocorticoid stress.…”

Section: Role Of Bdnf-related Intracellular Signaling In Action Of An...mentioning

confidence: 99%

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Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

Numakawa,

Kajihara

2023

Front. Mol. Neurosci.

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Interaction effect of crocin and citalopram on memory and locomotor activity in rats: an insight into BDNF and synaptophysin levels in the hippocampus

Nasseri,

Hajrasouliha,

Vaseghi

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Relationship between Dietary Iron and Cop-per Intake and Depressive Symptoms in Obese Population

唐

2023

ACM

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Increased Brain-Derived Neurotrophic Factor and Hippocampal Dendritic Spine Density Are Associated with the Rapid Antidepressant-like Effect of Iron-citalopram and Iron-Imipramine Combinations in Mice

Cited by 3 publications

References 82 publications

Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

Involvement of brain-derived neurotrophic factor signaling in the pathogenesis of stress-related brain diseases

Interaction effect of crocin and citalopram on memory and locomotor activity in rats: an insight into BDNF and synaptophysin levels in the hippocampus

Relationship between Dietary Iron and Cop-per Intake and Depressive Symptoms in Obese Population

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