Increased carotid artery plaque score is an independent predictor of the presence and severity of coronary artery disease

Morito, Natsumi; Inoue, Yukiko; Urata, Makiko; Yahiro, Eiji; Kodama, Sunao; Fukuda, Naoka; Saito, Naoko; Tsuchiya, Y.; Mihara, Hisakazu; Yamanouchi, Yoshio; Saku, Keijiro; Urata, Hidenori

doi:10.1016/j.jjcc.2007.09.003

Cited by 49 publications

(50 citation statements)

References 25 publications

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“…2) Thus, CPS has also been used for the risk assessment for cardiovascular events. 10) PWV is an indicator of both arterial stiffness and atherosclerosis. Brachial-ankle PWV (baPWV) measurement, which uses pressure cuffs wrapped round the brachium and ankle, has become the most widely used PWV index, and has been demonstrated to be a reliable predictor of cardiovascular risk in high risk patients.…”

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confidence: 99%

Impact of Combined Assessment of Coronary Artery Calcium Score, Carotid Artery Plaque Score, and Brachial-Ankle Pulse Wave Velocity for Early Coronary Revascularization in Patients With Suspected Coronary Artery Disease

et al. 2012

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SummaryCoronary artery calcium score (CACS) measured by multi-detector computed tomography, carotid plaque score (CPS) measured by carotid artery ultrasound, and brachial-ankle pulse wave velocity (baPWV) are noninvasive screening tools for coronary artery disease. The aim of this study was to determine whether the combination of CACS, CPS, and baPWV improves the prognostic value for future cardiac events. CACS, CPS, and baPWV were assessed in 77 patients (mean age, 65 years, 49 males) undergoing invasive coronary angiography. ECG-triggered MSCT was used to assess CACS. CPS was defined as the sum of all plaque heights in bilateral carotid arteries. The highest baPWV was used for analysis. Cardiac events were defined as cardiac death, nonfatal myocardial infarction, or coronary revascularization. Thirty-two cardiac events (41.6%) occurred during follow-up (23.6 ± 20.8 months), consisting of 28 PCIs and 4 CABGs. The best cutoff values of positive CACS, CPS, and baPWV for predicting cardiac events were ≥ 50, ≥ 5, and ≥ 1.6 m/ second, respectively. For the combination of the 3 modalities, the positive test was defined as having at least 1 positive result by each method. The negative predictive value of all 3 modalities combined was better than that of CACS alone. The event-free rate was higher in patients with negative results for all 3 parameters compared with those that were positive (100% versus 44.8%, P < 0.0001). The prognostic value of using combined assessment of CACS, CPS, and baPWV is more effective for predicting cardiac events than CACS alone. (Int Heart J 2012; 53: 154-159)

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confidence: 99%

Impact of Combined Assessment of Coronary Artery Calcium Score, Carotid Artery Plaque Score, and Brachial-Ankle Pulse Wave Velocity for Early Coronary Revascularization in Patients With Suspected Coronary Artery Disease

et al. 2012

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“…Morito et al [16] found that PS more closely represented the atherosclerotic status of the carotid artery than the IMT. They also found that subjects with carotid plaques in their study group had a higher risk of heart attack as compared to those with IMT.…”

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confidence: 99%

Association between Carotid Artery Plaque Score and SYNTAX Score in Coronary Artery Disease Patients

Chung¹

2017

Gen Med

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Background: Numerous studies have been published the correlation between plaque score (PS), mean carotid artery intima-media thickness (IMT), and the prevalence or complexity of coronary artery lesions in coronary artery disease (CAD) patients. However, very few studies have reported the association between the complexity of coronary artery lesions and PS and the mean carotid artery IMT. We therefore aimed to examine the correlation between carotid artery ultrasound parameters and complexity of coronary artery lesions in CAD patients.

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“…Согласно одномоментному исследова-нию Morito N, et al (2008) увеличение суммарной высоты бляшек на 1,0 мм коррелирует с увеличением риска наличия коронарного атеросклероза на 36% [34]. В исследовании Ikeda N, et al (2012) только сум-марная высота бляшек в отличие от ТИМ коррелиро-вала с умеренным (23-32) и выраженным (33 и более) поражением коронарного русла по шкале SYNTAX при коррекции на основные факторы риска, при этом чувствительность метода составила 96,1% при суммар-ной высоте бляшек >5 мм [35].…”

Section: Ultrasound Markers Of Premanifest Atherosclerosis Of Carotidunclassified

Ultrasound Markers of Premanifest Atherosclerosis of Carotid and Femoral Arteries in Assessment of Cardiovascular Risk

Ершова¹,

Бойцов

Драпкина³

et al. 2018

Russ J Cardiol

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92В настоящее время стратификация сердечно-сосу-дистого (СС) риска основана на оценке факторов риска и уровней биохимических маркеров, при этом традиционная оценка риска имеет общепризнанные ограничения, особенно в группах с более низким риском, таких как женщины, люди молодого и сред-него возраста [1][2][3]. Данные нескольких популяцион-ных исследований указывают на то, что более поло-вины СС событий происходит среди лиц, соответ-ствующих низкому или умеренному СС риску согласно широко применяемым шкалам (SCORE, Фрамингемская шкала) [4]. По данным разных иссле-дований, факторы риска объясняют только 52-66% совокупности причин, приведших к развитию атеро-склероза [5,6]. Большую долю составляет так называ-емый "необъясненный атеросклероз", развитие которого нельзя обосновать известными факторами риска [5]. При этом известно, что атеросклероз начи-нается в раннем возрасте и его распространенность и выраженность увеличиваются в течение жизни. Более половины сердечно-сосудистых событий происходит у лиц с низким или умеренным сердечно-сосудистым риском, который оценивается на основа-нии традиционных факторов риска. При этом с помощью ультразвукового исследования артерий удается выявить атеросклероз уже на ранних стадиях его развития. Высокая частота наличия субклинического атеросклероза у лиц низкого и умеренного сердечно-сосудистого риска, который одновременно является реализацией как традиционных, так и еще "необъясненных" факто-ров риска, ультразвуковые маркеры атеросклероза имеет высокий потенциал улучшить стратификацию сердечно-сосудистого риска. В данном обзоре рас-смотрены ультразвуковые маркеры атеросклероза с позиции их ассоциации с традиционными факторами риска, способности улучшать прогностическую ценность имеющихся шкал оценки риска, а также возможности влиять на исходы. Прогностическая значимость маркеров рассмотрена в рамках пер-вичной профилактики среди представителей общей популяции, среди лиц высокого риска, а также с позиции количественного индикатора степени ате-росклеротического поражения или способности выступать в качестве сурро-гатного маркера сердечно-сосудистых заболеваний. More than a half of cardiovascular events occur in low to moderate cardiovascular risk patients if assessed based on the traditional risk factors. At the same time, ultrasound examination of arteries makes it possible to reveal atherosclerosis even at early stages of its development. High prevalence of subclinical atherosclerosis in low to moderate risk patients, which is a realization of traditional and "unknown" risk factors, makes ultrasound examination a useful method for risk stratification. The review is focused on ultrasound markers of atherosclerosis with association to traditional risk factors, on the possibility to improve predictive role of current scores and influence on outcomes. Predictive significance of the markers is regarded for primary prevention in general population, in high risk persons and from the perspective of quantitative indicator of atherosclerotic lesion grade or plausibility as a surrogate c...

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Increased carotid artery plaque score is an independent predictor of the presence and severity of coronary artery disease

Abstract: Assessment of PS by carotid ultrasonography together with other risk factor assessment was clinically relevant to predict the presence and severity of CAS.

Cited by 49 publications

References 25 publications

Impact of Combined Assessment of Coronary Artery Calcium Score, Carotid Artery Plaque Score, and Brachial-Ankle Pulse Wave Velocity for Early Coronary Revascularization in Patients With Suspected Coronary Artery Disease

Impact of Combined Assessment of Coronary Artery Calcium Score, Carotid Artery Plaque Score, and Brachial-Ankle Pulse Wave Velocity for Early Coronary Revascularization in Patients With Suspected Coronary Artery Disease

Association between Carotid Artery Plaque Score and SYNTAX Score in Coronary Artery Disease Patients

Ultrasound Markers of Premanifest Atherosclerosis of Carotid and Femoral Arteries in Assessment of Cardiovascular Risk

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