Increased CD4+ T cell count is associated with lower anal human papillomavirus prevalence among HIV-positive male cohort in Taizhou, China: a cross-sectional study

Zhang, Jing; Chen, Xiaoxiao; Ye, Yiwen; Shen, Weiwei; Ye, Xiaohong; Lin, Yajun; Lin, Zhebin; Tan, Shigang; Gao, Min; Ding, Yingying; Lin, Huang; Wang, Youyi; He, Na; Liu, Xing

doi:10.1186/s12879-022-07251-3

Cited by 4 publications

(3 citation statements)

References 37 publications

(42 reference statements)

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“…However, men taking EFV+3TC+TDF treatment (Efavirenz, Lamivudine, and Zidovudine) did not show a significant increase in CD4+ cells or clearance of HPV infection. This confirms that CD4+ cells are important in eliminating HPV infections [ 123 ].…”

Section: Natural Hpv Immune Response In Mensupporting

confidence: 76%

The Immune Response Generated against HPV Infection in Men and Its Implications in the Diagnosis of Cancer

Chihu-Amparan

Pedroza-Saavedra

Gutiérrez‐Xicoténcatl

2023

Microorganisms

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Human papillomavirus (HPV) infection is associated with precancerous lesions and cancer of the genital tract both in women and men. The high incidence of cervical cancer worldwide focused the research on this infection mainly in women and to a lesser extent in men. In this review, we summarized epidemiological, immunological, and diagnostic data associated with HPV and cancer in men. We presented an overview of the main characteristics of HPV and infection in men that are associated with different types of cancer but also associated with male infertility. Men are considered important vectors of HPV transmission to women; therefore, identifying the sexual and social behavioral risk factors associated with HPV infection in men is critical to understand the etiology of the disease. It is also essential to describe how the immune response develops in men during HPV infection or when vaccinated, since this knowledge could help to control the viral transmission to women, decreasing the incidence of cervical cancer, but also could reduce other HPV-associated cancers among men who have sex with men (MSM). Finally, we summarized the methods used over time to detect and genotype HPV genomes, as well as some diagnostic tests that use cellular and viral biomarkers that were identified in HPV-related cancers.

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Section: Natural Hpv Immune Response In Mensupporting

confidence: 76%

The Immune Response Generated against HPV Infection in Men and Its Implications in the Diagnosis of Cancer

Chihu-Amparan

Pedroza-Saavedra

Gutiérrez‐Xicoténcatl

2023

Microorganisms

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“…Our previous study reported that the use of cART and an increase in CD4 þ T-cell count were associated with lower prevalence of anal infection with high-risk HPV in the same population [36]. In the current study, those with CD4 þ T-cell cell count higher than 500 cells/ml at HIV diagnosis showed lower HPV prevalence, incidence, persistence rate and higher HPV clearance rate.…”

Section: Discussionsupporting

confidence: 53%

“…A meta-analysis showed that cART was negatively correlated with anal high-risk HPV prevalence in people with HIV [46]. The improvement of the immune function represented by increased CD4 + T-cell count may be helpful in prevention or clearance of HPV infection, which also showed the importance of timely cART treatment in people with HIV [36]. As all participants from this study were under cART, we examined whether different antiviral drugs were associated with HPV incidence or clearance, and no significant association was detected.…”

Section: Discussionmentioning

confidence: 99%

Incidence, clearance, and factors associated with anal human papilloma virus infection among men with HIV

Zhang,

Sun,

Chen

et al. 2023

Aids

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Objectives: This study aims to estimate the incidence and persistence/clearance of anal HPV infection and related factors among men with HIV in Taizhou, China. Design: A prospective cohort study Methods: Men with HIV were recruited and followed up from 2016 to 2021. Questionnaire surveys were used to collect social-demographic and behavioral characteristics, and anal swabs were collected for HPV Genotyping. Results: A total of 675 men with HIV were recruited and followed up. After an average follow-up time of 1.75 years, HPV39 (3.8/100 person-years), HPV52 (3.6/100 person-years), HPV51 (3.1/100 person-years), HPV58 (2.5/100 person-years) and HPV16 (2.4 cases/100 person-years) in the high-risk types showed the highest incidence rate. In marriage with woman (aHR = 0.44, 95% CI: 0.20–0.99) showed an inverse association with HPV incidence, while bisexuality or undetermined sexual orientation (aHR = 2.62, 95% CI: 1.08–6.36) showed a positive association. For those infected at baseline, the top three high-risk HPV with the lowest clearance density were HPV52 (32.2/100 person-years), HPV58 (38.1/100 person-years), and HPV16 (43.5/100 person-years). Daily consumption of 1–28 grams alcohol (aHR = 0.62, 95% CI: 0.41∼0.95) showed an inverse association with HPV clearance, while illicit drug use (aHR = 3.24, 95% CI: 1.59∼6.59) showed a positive association. Conclusions: Anal HPV infection and clearance were both active in men with HIV in China. Marriage status and sexuality were associated with the incidence of HPV infection, while substance use including alcohol and illicit drug were associated with HPV clearance. More studies are needed to explore the risk factors of HPV persistence.

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Genome‐Wide Association Study of Persistent Anal Human Papillomavirus Infection Among HIV‐Positive Males in Taizhou, China: A Cohort Study

Zhang,

Shao,

Chen

et al. 2024

Journal of Medical Virology

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The determinants of persistent human papillomavirus (HPV) infection remain largely unknown, and existing studies have predominantly focused on the female population. Individual genetic background may influence the persistence of HPV infection, we the evidence overall and among human immunodeficiency virus (HIV)‐positive males are very limited. We conducted a genome‐wide association study (GWAS) to identify single nucleotide polymorphisms (SNPs) associated with anal HPV persistence, based on a cohort designed to study the natural history of anal HPV infection among HIV‐positive males in Taizhou, China from 2016 to 2022. A total of 322 HIV‐positive males with anal HPV infection, with a mean age of 43.0 (standard deviation [SD]: 13.8) years, were included in this GWAS. The median follow‐up time was 1.8 (interquartile range [IQR]: 1.5–2.0) years. The persistence of any type of HPV infection was 53.4%. After adjusting for age and sexual orientation, there were 2 SNPs with p < 1 × 10−5 and 24 SNPs with p < 1 × 10−4. The most closely associated with HPV persistence in additive models were rs7359031 (LOC105370461, odds ratio [OR]T/C = 0.36, 95% confidence interval [CI]: 0.24–0.56; p = 6.67 × 10−6) located at 14q21.1, and rs11046048 (PYROXD1, ORC/A = 0.41, 95% CI: 0.28–0.60; p = 7.80 × 10−6) located at 12p12.1. Other SNPs were mainly located at 6q23.3 (HBS1L‐MYB) and 6p21.33 (CCHCR1, PSORS1C3). LOC105370461, PYROXD1, HBS1L‐MYB, CCHCR1, and PSORS1C3 may be susceptible genes for HPV persistence. We appeal further studies to validate these associations and examine the underlying mechanisms.

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Increased CD4+ T cell count is associated with lower anal human papillomavirus prevalence among HIV-positive male cohort in Taizhou, China: a cross-sectional study

Cited by 4 publications

References 37 publications

The Immune Response Generated against HPV Infection in Men and Its Implications in the Diagnosis of Cancer

The Immune Response Generated against HPV Infection in Men and Its Implications in the Diagnosis of Cancer

Incidence, clearance, and factors associated with anal human papilloma virus infection among men with HIV

Genome‐Wide Association Study of Persistent Anal Human Papillomavirus Infection Among HIV‐Positive Males in Taizhou, China: A Cohort Study

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