Increased CD56+ NK cells and enhanced Th1 responses in human unexplained recurrent spontaneous abortion

Gao, Yihuai; Wang, P L

doi:10.4238/2015.december.22.36

Cited by 31 publications

(17 citation statements)

References 23 publications

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“…Differences in the number of immune cells at the maternal-fetal interface in women experiencing repeated-miscarriages of unknown cause have been reported (Gao and Wang 2015;Qian et al 2018). Given the role of each immunocompetent cell described above, an exquisite balance of endometrial immunocompetent cells must be maintained for successful pregnancies.…”

Section: Discussionmentioning

confidence: 99%

Endometrial Immunity for Embryo Implantation and Pregnancy Establishment

Kitazawa

Kimura

Nakamura

et al. 2020

Tohoku J. Exp. Med.

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The uterus is an organ for raising the fetus, and its lumen is lined by the endometrium. The endometrium is an important site for the implantation and maturation of fertilized eggs. The endometrium undergoes repetitive proliferation, maturation (decidualization), and exfoliation changes every menstrual cycle. At the same time, the number and type of endometrial immunocompetent cells vary during the menstrual cycle. At the implantation stage, the immunocompetent cells occupy approximately half of the endometrial cells. Immunocompetent cells normally eliminate pathogenic microorganisms to protect the body; however, they also promote immune tolerance to accept the fetus during pregnancy. The immunocompetent cells in the uterus can perform both these functions. With the establishment of pregnancy, stimuli from the trophoblast (placenta) and fetus can also change the immune environment of the uterus, and pregnancy can be maintained only when the immune system is well adapted to the stimuli of some hormones and the fetus. Immunity for the establishment of pregnancy is not simple because multiple immunocompetent cells are involved in establishing and maintaining pregnancy. To understand the immune mechanisms associated with the establishment of pregnancy, we have to learn about each immune cell. This review, therefore, discusses the roles and distribution of the immunocompetent cells inside the uterus during menstruation and early pregnancy.

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Section: Discussionmentioning

confidence: 99%

Endometrial Immunity for Embryo Implantation and Pregnancy Establishment

Kitazawa

Kimura

Nakamura

et al. 2020

Tohoku J. Exp. Med.

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“…51 Such high proportions of CD56 + CD16 − dNK cells are companioned by an enhanced Th1/Th2 ratio in RSA patients. 52 Moreover, the number of granulysin-positive CD56 bright dNK cells is increased in RSA, causing the apoptosis of extravillous trophoblast cells (EVTs). 53 Higher expression of NKp44 on CD56 bright CD16 − dNK cells and NKp46 on CD56 dim CD16 + dNK cells in RSA patients compared with normal controls correlates with higher dNK cytotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Trophoblast‐derived CXCL12 promotes CD56^brightCD82⁻CD29⁺ NK cell enrichment in the decidua

Han

Jin

Huang

et al. 2019

American J Rep Immunol

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Problem: Decidual natural killer (dNK) cells play key roles in maternal-fetal immune regulation, trophoblast invasion, and vascular remodeling, and most dNK cell populations are CD56 bright CD16 − NK cells. However, the enrichment and redistribution of dNK cells in the local decidua have not been clarified yet. Method of study:A total of 45 women with normal pregnancies and 8 unexplained recurrent spontaneous abortion (RSA) patients were included. We isolated primary human dNK (n = 53) and peripheral blood NK (pNK) cells (n = 5) from specimen and analyzed CD56, CD82, and CD29 by flow cytometry (FCM). We assessed their adhesion ability by cell counts of NK cells adhered to decidual stromal cells (DSCs) in a co-culture system. Results:We found that RSA patients had more CD56 dim dNK cells with lower CD82 and higher CD29 than women with normal pregnancies. There were negative correlations of CD82 to CD29 on CD56 dim and CD56 + dNK cells. In normal pregnancies, dNK cells had lower CD82 and higher CD29 expression with a stronger adhesion ability than pNK cells. Blocking CD82 on dNK cells increased the adhesive ability and CD29 expression, while blocking CD29 decreased the adhesive ability. Co-culturing dNK cells with trophoblast cells decreased CD82 expression and increased the adhesive ability of dNK cells and the percentage of CD56 bright NK cells, while blocking trophoblast-derived CXCL12 increased CD82 expression, decreased CD29 expression, and impaired the adhesive ability of NK cells. Conclusion: Trophoblast cells enhance the adhesive ability of NK cells to DSCs viathe CXCL12/CD82/CD29 signaling pathway and contribute to CD56 bright NK cell enrichment in the uterus. K E Y W O R D S abortion, adhesion, CD29, CD82, CXC12, decidua, NK, trophoblasts How to cite this article: Lu H, Jin L-P, Huang H-L, et al. Trophoblast-derived CXCL12 promotes CD56 bright CD82 − CD29 + NK cell enrichment in the decidua.Am J Reprod Immunol. 2020;83:e13203.

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“…По данным Gao и Wang, у пациенток со спонтанным абортом происходит увеличе-ние уровня NK-клеток и CD4(+)Т-лимфоцитов, соотноше-ния Т1/Т2, в то время как уровень CD8(+) популяции Т-клеток -низкий. Предполагается, что данные показате-ли могут быть использованы в качестве маркера у жен-щин с наличием факторов риска прерывания беремен-ности [25].…”

Section: эндометриозunclassified

Chronic endometritis and habitual miscarriage

Манухин¹,

Sementsova²,

Mitrofanova³

et al. 2018

Med. sov.

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Increased CD56+ NK cells and enhanced Th1 responses in human unexplained recurrent spontaneous abortion

Cited by 31 publications

References 23 publications

Endometrial Immunity for Embryo Implantation and Pregnancy Establishment

Endometrial Immunity for Embryo Implantation and Pregnancy Establishment

Trophoblast‐derived CXCL12 promotes CD56^brightCD82⁻CD29⁺ NK cell enrichment in the decidua

Chronic endometritis and habitual miscarriage

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Increased CD56+ NK cells and enhanced Th1 responses in human unexplained recurrent spontaneous abortion

Cited by 31 publications

References 23 publications

Endometrial Immunity for Embryo Implantation and Pregnancy Establishment

Endometrial Immunity for Embryo Implantation and Pregnancy Establishment

Trophoblast‐derived CXCL12 promotes CD56brightCD82−CD29+ NK cell enrichment in the decidua

Chronic endometritis and habitual miscarriage

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Trophoblast‐derived CXCL12 promotes CD56^brightCD82⁻CD29⁺ NK cell enrichment in the decidua