Increased cerebrospinal fluid YKL-40 levels are associated with disease severity of neuromyelitis optica spectrum disorders

Qi, Yuan; Chou, Li-Sha; Zhang, Linjie; Liu, Mingqi; Yi, Ming; Zhang, Qiuxia; Wang, Jing; Li, Ting; Zhang, Da-Qi; Yang, Li

doi:10.1016/j.msard.2020.102395

Cited by 7 publications

(9 citation statements)

References 22 publications

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“…This is consistent with the results published by Qi et al. ( 2020 ). However, they only investigated the correlation between YKL‐40 and NMOSD, whereas in our study, the relationship between YKL‐40, sCD163, and sCD14 was investigated simultaneously.…”

Section: Discussionsupporting

confidence: 94%

“…Moreover, these biomarkers were all significantly associated with disease severity. This is consistent with the results published by Qi et al (2020). However, they only investigated the correlation between YKL-40 and NMOSD, whereas in our study, the relationship between YKL-40, sCD163, and sCD14 was investigated NMOSD is an autoimmune disease characterized by optic neuritis and myelitis.…”

Section: Discussionsupporting

confidence: 92%

“…Chitinase‐3‐like‐1, also known as YKL‐40, is secreted by activated macrophages and microglia (Craig‐Schapiro et al., 2010 ; Litvack & Palaniyar, 2010 ; Qi et al., 2020 ). Increased levels of YKL‐40 in the cerebrospinal fluid (CSF) are associated with a variety of neuroimmune and neuroinflammatory diseases, such as MS, autoimmune encephalitis, and stroke (Chen et al., 2018 ; Correale & Fiol, 2011 ; Hjalmarsson et al., 2014 ; Oldoni et al., 2020 ; Qi et al., 2020 ). CD14, a leukocyte differentiation antigen of activated macrophages/microglia and neutrophils, is a lipopolysaccharide receptor and includes a cell membrane type (mCD14) and a soluble type (sCD14) (Jespersen et al., 2016 ).…”

Section: Introductionmentioning

confidence: 99%

“…Some biomarkers directly reflect the process of microglial/macrophage activation (Pranzatelli et al., 2017 ). Chitinase‐3‐like‐1, also known as YKL‐40, is secreted by activated macrophages and microglia (Craig‐Schapiro et al., 2010 ; Litvack & Palaniyar, 2010 ; Qi et al., 2020 ). Increased levels of YKL‐40 in the cerebrospinal fluid (CSF) are associated with a variety of neuroimmune and neuroinflammatory diseases, such as MS, autoimmune encephalitis, and stroke (Chen et al., 2018 ; Correale & Fiol, 2011 ; Hjalmarsson et al., 2014 ; Oldoni et al., 2020 ; Qi et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

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Microglial/macrophage activation in the cerebrospinal fluid of neuromyelitis optica spectrum disorders

Wang

et al. 2022

Brain and Behavior

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Aim:The aims of this pilot study were to investigate the levels of biomarkers of microglial/macrophage activation-YKL-40, sCD163, and sCD14-in patients with neuromyelitis optica spectrum disorder (NMOSD) and determine the possible associations between these biomarkers and Expanded Disability Status Scale (EDSS) scores. Methods:We measured the levels of three microglia-/macrophage-related proteins (YKL-40, soluble CD163, and soluble CD14) in cerebrospinal fluid (CSF) using enzymelinked immunosorbent assays. In addition, patients' neurological disability levels were assessed using EDSS scores.Results: NMOSD patients had significantly higher CSF levels of

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Section: Discussionsupporting

confidence: 94%

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Microglial/macrophage activation in the cerebrospinal fluid of neuromyelitis optica spectrum disorders

Wang

et al. 2022

Brain and Behavior

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“…In the brain, the limited yet emerging literature demonstrates that CHI3L1 is primarily secreted by activated astrocytes and indicates a neurotoxic inflammatory state of neuroinflammation (2,(11)(12)(13). CHI3L1 is a high-profile biomarker for an array of neurological disorders hallmarked by neuroinflammation, including the neurodegenerative condition of Alzheimer's disease (14,15), the malignancy of glioblastoma (13,16), and autoimmune disorders such as multiple sclerosis (17) and neuromyelitis optica (NMO) spectrum disorder (18)(19)(20). To date, little is known about the biological role of this astroglial factor CHI3L1 in neuroinflammation and CNS disease manifestations.…”

Section: Introductionmentioning

confidence: 99%

CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation

Jiang,

Zhu,

et al. 2023

Sci. Adv.

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Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain and is known as a reliable biomarker for inflammatory central nervous system (CNS) conditions such as neurodegeneration and autoimmune disorders like neuromyelitis optica (NMO). NMO is an astrocyte disease caused by autoantibodies targeting the astroglial protein aquaporin 4 (AQP4) and leads to vision loss, motor deficits, and cognitive decline. In this study examining CHI3L1’s biological function in neuroinflammation, we found that CHI3L1 expression correlates with cognitive impairment in our NMO patient cohort. Activated astrocytes secrete CHI3L1 in response to AQP4 autoantibodies, and this inhibits the proliferation and neuronal differentiation of neural stem cells. Mouse models showed decreased hippocampal neurogenesis and impaired learning behaviors, which could be rescued by depleting CHI3L1 in astrocytes. The molecular mechanism involves CHI3L1 engaging the CRTH2 receptor and dampening β-catenin signaling for neurogenesis. Blocking this CHI3L1/CRTH2/β-catenin cascade restores neurogenesis and improves cognitive deficits, suggesting the potential for therapeutic development in neuroinflammatory disorders.

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BTK and YKL-40 Levels and Their Association with Acute AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder

Liu,

Wang,

Shi

et al. 2024

Mol Neurobiol

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Increased cerebrospinal fluid YKL-40 levels are associated with disease severity of neuromyelitis optica spectrum disorders

Cited by 7 publications

References 22 publications

Microglial/macrophage activation in the cerebrospinal fluid of neuromyelitis optica spectrum disorders

Microglial/macrophage activation in the cerebrospinal fluid of neuromyelitis optica spectrum disorders

CHI3L1 signaling impairs hippocampal neurogenesis and cognitive function in autoimmune-mediated neuroinflammation

BTK and YKL-40 Levels and Their Association with Acute AQP4-IgG-Positive Neuromyelitis Optica Spectrum Disorder

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