Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy

Hashimoto, Yuki; Saito, Wataru; Saito, Michiyuki; Hirooka, Kiriko; Mori, Shiro; Noda, Kousuke; Ishida, Susumu

doi:10.1007/s10384-015-0380-6

Cited by 28 publications

(35 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…And even despite the fact that LSFG has on occasion been used to analyze the blood flow of the optic disc in glaucomatous eyes, there have been few reports that have used LSFG as a clinical diagnostic tool. [12, 26] A previous report showed that LSFG could be used to monitor changes in the ocular blood flow caused by nonischemic type central retinal vein occlusion. [27] Our results also suggested that LSFG-wide could be used for non-invasive observation of the circulatory dynamics in the posterior region, including the optic disc and macular lesions.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy

et al. 2017

View full text Add to dashboard Cite

PurposeWe investigated whether laser speckle flowgraphy (LSFG) results are comparable in both eyes and whether it is useful in the diagnosis of disparity in ocular ischemic syndrome (OIS) patients.MethodsWe compared the mean blur rate (MBR) value for various fundus regions in both eyes of 41 healthy subjects and 15 internal carotid artery occlusion (ICAO) cases. We calculated the standard value of the Laterality Index (LI), which was the MBR comparison of both eyes in each of the regions, in the control subjects. We then investigated the correlation between both eyes for the LIs in the entire fundus, the degree of ICAO and visual function.ResultsThe disparity of the LIs in both eyes was least in the entire area of the fundus in control subjects and there was a significant correlation between both eyes of the 41 healthy individuals (P = 0.019). Significant correlations were found for the LI, visual acuity and degree of ICAO. The specificity and sensitivity of LI in the entire area was 93.8% and 100%, respectively.ConclusionsLSFG revealed normal individuals have symmetrical fundus blood flow. LSFG could detect OIS and might be a useful tool for detecting disparities in fundus blood flow.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy

et al. 2017

View full text Add to dashboard Cite

show abstract

“…S1A; right, dotted line). To evaluate changes in average MBR, the changing rate of average MBR against the initial baseline value was used, as previously described, 17,[19][20][21][22][23][24][25][26] since the MBR is an index of ''relative'' blood flow velocity. …”

Section: Mean Blur Rate Measurements On Lsfgmentioning

confidence: 99%

“…The macular MBR, largely derived from the choroid, 16 has been used to evaluate choroidal hemodynamics in various diseases. [17][18][19][20][21][22][23][24][25][26] Our recent study on CSC demonstrates that the macular MBR increases at the acute stage, 19 reinforcing the suspected role of choroidal hyperperfusion in the development of acute CSC. 10 With recent advances of LSFG, various parameters can be automatically calculated to analyze the pulse waveform of MBR averaged in a single heartbeat, 14,[27][28][29][30][31] including the skew, blowout time (BOT), and acceleration time index (ATI), all of which are expressed as absolute values.…”

mentioning

confidence: 99%

Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Saito

Hirooka

et al. 2015

Invest. Ophthalmol. Vis. Sci.

Self Cite

View full text Add to dashboard Cite

“…Changes in the blood flow and thickness may be manifestations of a process with an “inflammatory” pattern occurring in the choroid [18, 25]. Similarly, these changes have been also observed in unilateral acute idiopathic maculopathy [20], acute posterior multifocal placoid pigment epitheliopathy [26], and acute zonal occult outer retinopathy complex [17, 19, 27–30]. In contrast, both the blood flow velocity and thickness increased in the acute stage of central serous chorioretinopathy [16, 31], which involves a sympathetic or adrenergic etiology.…”

Section: Discussionmentioning

confidence: 99%

“…The software automatically set each circle at the same site where a previous circle had been set at baseline during follow-up. To evaluate changes in average MBR, which is a quantitative index of the “relative” blood flow velocity, the changing rates of average MBR against the initial baseline values (defined as 100%) were utilized, as previously described [16–20]. …”

Section: Case Presentationmentioning

confidence: 99%

Blood flow velocity and thickness of the choroid in a patient with chorioretinopathy associated with ocular blunt trauma

et al. 2017

Self Cite

View full text Add to dashboard Cite

Background: Choroidal circulation hemodynamics in eyes with ocular blunt trauma has not been quantitatively examined yet. We quantitatively examined changes in choroidal blood flow velocity and thickness at the lesion site using laser speckle flowgraphy (LSFG) and enhanced depth imaging optical coherence tomography (EDI-OCT) in a patient with chorioretinopathy associated with ocular blunt trauma. Case presentation: A 13-year-old boy developed a chorioretinal lesion with pigmentation extending from the optic disc to the superotemporal side in the right eye after ocular blunt trauma. The patient's best-corrected visual acuity (BCVA) was 0.2 in the right eye. Indocyanine green angiography showed hypofluorescence from the initial phase, with a decrease of mean blur rate (MBR) on LSFG color map, which corresponded to the chorioretinal lesion. The BCVA and foveal outer retinal morphologic abnormality spontaneously improved during follow-up. MBR and choroidal thickness increased by 23-31% and 13-17 μm at the lesion site and by 11-22% and 33-42 μm at the fovea, respectively, during the 6-month follow-up period after baseline measurements in the affected eye. In contrast, these parameters showed little or no changes at the normal retinal site in the affected eye and the fovea in the fellow eye. Conclusions: Current data revealed that both blood flow velocity and thickness in the choroid at the lesion site decreased in the acute stage and subsequently increased together with improvements in visual function and outer retinal morphology. These results suggest that LSFG and EDI-OCT may be useful indices that can noninvasively evaluate activity of choroidal involvement in ocular blunt trauma-associated chorioretinopathy.

show abstract

Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy

Abstract: These results reveal that there is a significant elevation of choroidal blood flow velocity and substantial reduction of choroidal thickness with regression of UAIM, suggesting that impaired choroidal circulation may be involved in the pathogenesis of UAIM.

Cited by 28 publications

References 23 publications

Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy

Evaluation of Fundus Blood Flow in Normal Individuals and Patients with Internal Carotid Artery Obstruction Using Laser Speckle Flowgraphy

Pulse Waveform Changes in Macular Choroidal Hemodynamics With Regression of Acute Central Serous Chorioretinopathy

Blood flow velocity and thickness of the choroid in a patient with chorioretinopathy associated with ocular blunt trauma

Contact Info

Product

Resources

About