Increased circulating CRTH2+Tregs are associated with asthma control and exacerbation

Chantveerawong, Teerapol; Sangkangjanavanich, Sasipa; Chiewchalermsri, Chirawat; Pradubpongsa, Panitan; Mitthamsiri, Wat; Jindarat, Sarawut; Wang, Ming; Akdiş, Mübeccel; Sokołowska, Milena; Sangasapaviliya, Atik; Boonpiyathad, Tadech

doi:10.1111/all.15145

Cited by 13 publications

(7 citation statements)

References 7 publications

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“…IL-10-producing ILC2s in humans are derived from immature (CRTH2 – ) and mature (CRTH2 + ) ILC2s expressing KLRG1, as KLRG1 – CRTH2 + ILC2s, which are yet to be properly defined, failed to produce IL-10 under stimulation with IL-2, IL-7, IL-33 and retinoic acid 13 . Notably, circulating KLRG1 + ILC2s from individuals with allergic disease were unable to produce IL-10, but the capacity of ILC2s to produce IL-10 was restored following successful allergen immunotherapy, which suggests that human IL-10-producing ILC2s might be involved in the control of allergic responses 13 , 35 , 36 . However, it has not yet been confirmed whether human IL-10-producing ILC2s reside in lung and intestine as well as nasal tissue as is the case in mice.…”

Section: Ilc2s With Regulatory Functionsmentioning

confidence: 99%

Heterogeneity of type 2 innate lymphoid cells

Spits

Mjösberg

2022

Nat Rev Immunol

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More than a decade ago, type 2 innate lymphoid cells (ILC2s) were discovered to be members of a family of innate immune cells consisting of five subsets that form a first line of defence against infections before the recruitment of adaptive immune cells. Initially, ILC2s were implicated in the early immune response to parasitic infections, but it is now clear that ILC2s are highly diverse and have crucial roles in the regulation of tissue homeostasis and repair. ILC2s can also regulate the functions of other type 2 immune cells, including T helper 2 cells, type 2 macrophages and eosinophils. Dysregulation of ILC2s contributes to type 2-mediated pathology in a wide variety of diseases, potentially making ILC2s attractive targets for therapeutic interventions. In this Review, we focus on the spectrum of ILC2 phenotypes that have been described across different tissues and disease states with an emphasis on human ILC2s. We discuss recent insights in ILC2 biology and suggest how this knowledge might be used for novel disease treatments and improved human health.

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Section: Ilc2s With Regulatory Functionsmentioning

confidence: 99%

Heterogeneity of type 2 innate lymphoid cells

Spits

Mjösberg

2022

Nat Rev Immunol

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“…Dysfunctional CRTH2 + Tregs are Th2-like phenotypes and associated with allergic symptoms. 7,8 There was no statistical difference in the frequencies of T cell subsets and Der p 2-specific IgG4, IgE, and IgE/ IgG4 ratios between both groups, and no difference between baseline and at week 12 (Figure 1E,F). Thus, no significant immunological change after switching from SCIT to SLIT was observed in this study.…”

Section: E T T E R S Switching From Subcutaneous To Sublingual Immuno...mentioning

confidence: 93%

Switching from subcutaneous to sublingual immunotherapy during the maintenance phase in patients with house dust mite allergy

Kiatiwat

Sangasapaviliya

Pradubpongsa

et al. 2023

Allergy

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“…Chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2) is a type 2 receptor for prostaglandin D2 (PGD2) that is expressed on Th2 and other cell types such as Tregs [14]. It has been reported that the frequency of CRTH2 + Tregs was increased in patients with asthma, especially during an acute asthma exacerbation, correlating with asthma control [116]. Therefore, asthmatic patients display lower numbers of Tregs, with low CCR5 expression and high CRTH2 expression, demonstrating lower functionality and a Th2-biased character.…”

Section: Tregs In Allergic Asthmamentioning

confidence: 99%

The Role of Regulatory T Cells in Allergic Diseases: Collegium Internationale Allergologicum (CIA) Update 2024

Martín-Cruz,

Benito-Villalvilla,

Sirvent

et al. 2024

Int Arch Allergy Immunol

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Background: Allergy represents a major health problem of increasing prevalence worldwide with a high socioeconomic impact. Our knowledge on the molecular mechanisms underlying allergic diseases and their treatments has significantly improved over the last years. The generation of allergen-specific regulatory T cells (Tregs) is crucial in the induction of healthy immune responses to allergens, preventing the development and worsening of allergic diseases. Summary: In the last decades, intensive research has focused on the study of the molecular mechanisms involved in Treg development and Treg-mediated suppression. These mechanisms are essential for the induction of sustained tolerance by allergen-specific immunotherapy (AIT) after treatment discontinuation. Compelling experimental evidence demonstrated altered suppressive capacity of Tregs in patients suffering from allergic rhinitis, allergic asthma, food allergy, or atopic dermatitis, as well as the restoration of their numbers and functionality after successful AIT. Key Message: The better understanding of the molecular mechanisms involved in Treg generation during allergen tolerance induction might well contribute to the development of novel strategies for the prevention and treatment of allergic diseases.

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Increased circulating CRTH2⁺Tregs are associated with asthma control and exacerbation

Cited by 13 publications

References 7 publications

Heterogeneity of type 2 innate lymphoid cells

Heterogeneity of type 2 innate lymphoid cells

Switching from subcutaneous to sublingual immunotherapy during the maintenance phase in patients with house dust mite allergy

The Role of Regulatory T Cells in Allergic Diseases: Collegium Internationale Allergologicum (CIA) Update 2024

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