Increased Circulating Levels of Insulin-Like Growth Factor-I and Decreased Circulating Levels of Insulin-Like Growth Factor Binding Protein-1 in Postmenopausal Women with Endometrial Cancer.

Abstract

Abstract. In human endometrium insulin-like growth factor binding protein (IGFBP)-1 inhibits the mitogenic action of insulin-like growth factor (IGF)-I by inhibiting the binding of IGF-I to its receptor. Our purpose was to compare circulating levels of IGF-I and IGFBP-1 in women with and without endometrial cancer. We assessed circulating levels of IGF-I and IGFBP-1 and IGFBP-3 in 23 patients with endometrial cancer, 11 patients with uterine cervical cancer and 27 healthy control women. The mean circulating level of IGF-I decreased significantly following menopause but was not correlated with age in the control group. The body mass index was significantly higher in the endometrial cancer group than in the control group. Analysis of covariance showed that even after the data were adjusted to eliminate the influence of the body mass index, the circulating IGF-I concentration was higher in postmenopausal endometrial cancer patients than in postmenopausal control subjects. The mean circulating level of IGFBP-1 was significantly lower in postmenopausal cancer patients than in postmenopausal control subjects. There were no significant differences in the serum levels of IGF-I and IGFBP-1 in the patients with cervical cancer and the control group. In conclusion, an increased circulating concentration of IGF-I and a decreased circulating concentration of IGFBP-1 are associated with endometrial cancer especially in postmenopausal women.

Niveles séricos de los factores de crecimiento similares a la insulina I y II y su proteína 3 de enlace en mujeres con lesiones escamosas intraepiteliales y cáncer de cuello uterino

“…Ayabe et al (35), in a small study of 11 cervical cancer patients and 27 controls, found not significant association between serum levels of IGF-I and cervical cancer risk.…”

The Relationship Between Endometrial Polyps, Obesity, the Incidence of Diabetes and Hypertension in Women Who Admitted with Abnormal Uterin Bleeding in Reproductive Ages

“…Ayabe ve ark. 17 tarafından yapılan çalışmada endometrium kanserli kadınların serum IGF-1 düzey-lerinin kontrol grubuna nazaran daha yüksek olduğu saptanmıştır. Bu bulgu da obezite, DM ve HT varlığının …”

Does IGF-1 play a role in the biology of endometrial cancer?

“…However, these studies are scarce and the results remain inconsistent (Table 3) [10,[28][29][30][31][32][33][34][35]. Four studies found no association between serum IGF-1 and EC biology [10,[28][29][30].…”