Increased circulating Th22 cells correlated with Th17 cells in patients with severe preeclampsia

Zhang, Zhan; Liu, Hui; Shi, Ying; Xu, Na; Wang, Yuanyuan; Li, Aiping; Song, Wanyu

doi:10.1080/10641955.2016.1239737

Cited by 33 publications

(29 citation statements)

References 25 publications

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“…Of note, IL‐17A correlated with IL‐2 and IFN‐γ production, suggesting that T H 17 cells mediate their function by stimulating T H 1 cytokines . This was in agreement with the study of Zhang et al, which additionally indicated a positive linear correlation between T H 17 and T H 22 cells ( r = 0.461, P ‐value = 0.013). Interestingly, IL‐17 was found to be expressed not only in T H 17, but also in CD8 and NK cells of PE women .…”

Section: Resultssupporting

confidence: 90%

“…The maternal serum IL‐17 levels have been investigated by several observational studies, although resulting in conflicting results. Two case‐control studies, including 60 and 119 women, respectively, measured significantly higher third‐trimester IL‐17 levels in the PE group . This finding was confirmed by Cao et al, observing higher IL‐17 mRNA expression in peripheral blood mononuclear cells (PBMCs), as well as elevated IL‐17 serum levels, both in mild and severe PE.…”

Section: Resultsmentioning

confidence: 54%

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The role of interleukins in preeclampsia: A comprehensive review

Bellos

Karageorgiou

Kapnias

et al. 2018

American J Rep Immunol

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Preeclampsia is a multi‐system hypertensive disorder of pregnancy, with significant rates of maternal and neonatal morbidity. It represents a major cause of preterm birth, as definitive treatment demands fetal delivery. Although its pathophysiology is complicated, placental hypoxia and endothelial dysfunction constitute established pathogenetic steps of the disease. Inflammation is considered to be a crucial mediator of preeclampsia process, as an imbalance between TH1, TH2, and TH17 immune responses is observed. The present review accumulates current knowledge about the contribution of interleukins in preeclampsia, summarizing the pathways through which each interleukin exerts its function in the disease. Also, the role of genetic polymorphisms is explored and the predictive efficacy of maternal serum interleukin levels is evaluated. Finally, recommendations about the safe interpretation of the outcomes, as well as guidance for future research, are provided.

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Section: Resultssupporting

confidence: 90%

Section: Resultsmentioning

confidence: 54%

The role of interleukins in preeclampsia: A comprehensive review

Bellos

Karageorgiou

Kapnias

et al. 2018

American J Rep Immunol

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“…These correlations go in hand with Zhang et al (24) who detected a positive correlation between plasma IL-22 concentration and the percentage of Th22 cells and severe PE patients and data obtained by Poordast et al (26) support the rational of imbalance of cytokine profile in PE patients.…”

mentioning

confidence: 52%

“…Also, Cornelius et al (23) experimentally found on transfer of Th17 cells resulting from reduced uterine perfusion in induced tissue oxidative stress, increased serum IL-6 and causes increased blood pressure and intrauterine growth restriction and concluded that autoimmune status associated with Th17 cells may have a role in pathogenesis of PE. Thereafter, Zhang et al (24) found plasma concentrations of IL-17 and IL-22 were significantly increased along with a decreased plasma IL-10 concentration in severe PE patients and Ribeiro et al (25) found plasma levels of IL-6, IL-17 and TNF-α were significantly higher whereas IL-10 levels were significantly lower in PE than in normotensive women. Also, Poordast et al…”

mentioning

confidence: 99%

Disturbed Maternal Immune Milieu Early in Pregnancy Could Predict Later Development of Pre-Eclampsia and Differentiate Its Severity Grades.

Sharafeldeen¹,

Rahman²

2018

IJAR

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“…On the other hand, Treg cells are considered to play a crucial role in the implantation of embryos and the maintenance of maternal immune tolerance to the fetus . Zhang et al . demonstrated that the percentage of Treg cells defined as CD4 + CD25 + CD127 low was significantly lower in women with severe PE compared with healthy pregnant women.…”

Section: Discussionmentioning

confidence: 99%

Association between cytokine profile and transcription factors produced by T‐cell subsets in early‐ and late‐onset pre‐eclampsia

et al. 2017

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Pre-eclampsia (PE) is an obstetric pathology characterized by abnormal activation of the innate and adaptive immune systems dependent on the imbalance of T helper subsets. The present study aimed to evaluate the gene and protein expression of T helper type 1 (Th1)/Th2/Th17/regulatory T (Treg) cell transcription factors in peripheral blood lymphocytes from pregnant women with PE employing quantitative RT-PCR and flow cytometry techniques, as well as the cytokine profile produced by these CD4 T-cell subsets in the plasma of pregnant women with PE, classified as early-onset PE (n = 20), late-onset PE (n = 20) and normotensive pregnant women (n = 20). Results showed a higher percentage of CD4 T cells expressing the RORc transcription factor (Th17) and a lower percentage of cells expressing FoxP3 (Treg) in women with early-onset PE compared with late-onset PE and normotensive groups. A lower gene expression of GATA-3 transcription factor was detected in cells of women with early-onset PE compared with the late-onset PE group. Endogenous plasma levels of interleukin-6 (IL-6), IL-17 and tumour necrosis factor-α were significantly higher in the early-onset PE group than in the late-onset PE and normotensive groups, whereas IL-4 (Th2 profile) and IL-22 (Th17 profile), were not significantly different between the studied groups. The endogenous levels of transforming growth factor-β and IL-10 were significantly lower in the pre-eclamptic than in the normotensive groups of the same gestational age, with a significant difference between early- and late-onset PE. The results show that in women with PE there is an imbalance between inflammatory and anti-inflammatory profiles in CD4 T-cell subsets, with polarization to Th17 profiles in the early-onset PE, considered as the severe form of PE.

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Increased circulating Th22 cells correlated with Th17 cells in patients with severe preeclampsia

Abstract: Increased circulating Th22 cells, which were correlated with Th17 cells, were observed in patients with sPE. The immune imbalance between T helper (Th) cells may contribute to the pathogenesis of sPE.

Cited by 33 publications

References 25 publications

The role of interleukins in preeclampsia: A comprehensive review

The role of interleukins in preeclampsia: A comprehensive review

Disturbed Maternal Immune Milieu Early in Pregnancy Could Predict Later Development of Pre-Eclampsia and Differentiate Its Severity Grades.

Association between cytokine profile and transcription factors produced by T‐cell subsets in early‐ and late‐onset pre‐eclampsia

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