Increased Corneal Thickness in Active Behçet's Disease

Evereklioğlu, Cem; Er, Hamdi̇

doi:10.1177/112067210201200105

Cited by 40 publications

(27 citation statements)

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“…One study in Behçet panuveitis patients revealed a significantly increased corneal thickness (5%) in patients with active inflammation compared to the unaffected side and to the control group [3] . The magnitude of increase was higher in our patients' series, with a 10% increase in normal thickness compared to the unaffected side.…”

Section: Discussionmentioning

confidence: 99%

“…In patients with active anterior uveitis, an increase in corneal thickness is frequently seen due to the presence of endothelial precipitates associated with a corneal edema [3,4] . IOP measurements are required during acute inflammation to exclude elevated IOP and may help to detect an underlying association as for example IOP is elevated in herpetic anterior uveitis or in ocular sarcoidosis.…”

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confidence: 99%

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Influence of Corneal Thickness Changes during Active Uveitis on Goldmann Applanation and Dynamic Contour Tonometry

et al. 2012

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Background: To compare the influence of central corneal thickness (CCT) during active anterior uveitis and after resolution on intraocular pressure (IOP) measurements by Goldmann applanation tonometry (GAT) and by dynamic contour tonometry (DCT). Design: Prospective, single-center study including 30 consecutive patients with active unilateral uveitis. Main Outcome Measure: CCT influence on GAT and DCT in active uveitis. Results: Average age of included patients (total n = 30; 16 women) was 46.5 years (range: 22.3–75.4). During activity, the cornea was thicker than on the unaffected side (645 vs. 585 µm, p = 0.0001). At the follow-up visit (inactive time point), the corneal thickness of the affected eye fell to a CCT of 581 µm (p < 0.0001). IOP measured by DCT was always higher than that measured by GAT. IOP was significantly lower during the active phase (GAT = 14.3 ± 5.8 mm Hg, DCT = 16.3 ± 5.9 mm Hg) than when disease was inactive (GAT = 17 ± 6.2 mm Hg, p = 0.016; DCT = 19.6 ± 6.9 mm Hg, p = 0.0006). The two techniques showed a high concordance, with a correlation coefficient of 0.76 (p < 0.001) in the affected eye at the active time point and when inactive 0.95 (p < 0.001). In addition, no systematic difference between these two techniques was observed according to the Bland-Altman method of comparison. No correlation between ΔIOP (GAT – DCT) and CCT could be detected at either time point. Conclusions: CCT increases during active phases of anterior uveitis. The edematous corneas lead to an additional decrease in IOP measurements by GAT and DCT. Both techniques were in good concordance in the patients, and the difference between GAT and DCT IOP readings was not influenced by CCT.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Influence of Corneal Thickness Changes during Active Uveitis on Goldmann Applanation and Dynamic Contour Tonometry

et al. 2012

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“…Although the aetiopathogenesis of the disease has not yet been clarified, several mechanisms such as genetics, infection, immunoglobulin, immune complexes and antibodies have all been suggested as the causes of BD. 4,6 It affects almost every tissue and organ in the body without exception, including the cornea, 7 inner ear 8 and the lung. 9 The intermittent nature and the lack of consistent response to therapy make the underlying aetiology difficult to define.…”

Section: Introductionmentioning

confidence: 99%

Serum levels of TNF‐α, sIL‐2R, IL‐6, and IL‐8 are increased and associated with elevated lipid peroxidation in patients with Behçet′s disease

Evereklioğlu

Türköz

et al. 2002

Mediators of Inflammation

223

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AIM: Behçet's disease (BD) is asystemic immunoinflammatory disorder and the aetiopathogenesis is to be specified. Cytokines play a role in immune response and in many inflammatory diseases. The aim of this case-control study is to investigate serum pro-inflammatory cytokine tumour necrosis factor (TNF)-alpha, interleukin-1beta (IL-1beta), soluble IL-2 receptor (sIL-2R), IL-6, and chemokine IL-8 levels in patients with BD. We also determined the end product of lipid peroxidation (malondialdehyde (MDA)) in BD patients as an index for oxidative stress. METHODS: A total of 37 patients (19 men, 18 women) with BD (active, n = 17; inactive, n = 20) and 20 age-matched and sex-matched healthy control subjects (11 men, nine women) included in this cross-sectional, blinded study. Serum TNF-alpha, IL-1beta, sIL-2R, IL-6 and IL-8 levels were determined by a spectrophotometer technique using the immulite chemiluminescent immunometric assay. Lipid peroxidation was evaluated by Wasowicz et aL The levels of cytokines and lipid peroxidation in the active period were compared with the inactive period of the disease. Results are expressed as mean +/- standard error. RESULTS: IL-1beta levels were below the detection limits of the assay (< 5 pg/ml) in all samples. Mean levels of MDA (8.1+/-0.7 micromol/l), sIL-2R (800+/-38 U/ml), IL-6 (12.6+/-1.1 pg/ml), IL-8 (7.2+/-0.4 pg/ml), and TNF-alpha (7.9+/-0.5 pg/ml) in active BD patients were significantly higher than those in inactive patients (4.3+/-0.5 micromol/l, p < 0.01; 447+/-16 U/ml, p < 0.001; 8.3+/-0.6 pg/ml, p = 0.006; 5.3+/-0.1 pg/ml, p < 0.001; and 5.1 0.2 pg/ml, p < 0.001; respectively) or control subjects (2.1+/-0.2 micromol/l, p < 0.001; 446+/-20 U/ml, p < 0.001; 6.4+/-0.2 pg/ml, p < 0.001; 5.4+/-0.1 pg/ml, p < 0.001; and 4.7+/-0.1 pg/ml, p < 0.001, respectively). On the contrary, only the mean IL-6 level was significantly different between inactive BD and control subjects (p = 0.02). All acute phase reactants were significantly higher in active BD than in inactive period (for each, p < 0.01). Conclusions: High levels of sIL-2R, IL-6, IL-8 and TNF-alpha indicate the activation of immune system in BD. Serum sIL-2R, IL-6, IL-8 and TNF-alpha seem to be related to disease activity. Increased lipid peroxidation suggests oxidative stress in BD and therefore tissue damage in such patients. Amelioration of clinical manifestations would be envisaged by targeting these cytokines, chemokines and lipid peroxidation with pharmacological agents.

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“…1,2 Anterior segment inflammation may affect corneal endothelium; following that, some corneal changes may occur in uveitic eyes. [3][4][5][6][7][8][9][10] The response of corneal endothelium can be assessed clinically by central corneal thickness (CCT) measurements. 11,12 In the present study, we measured CCT in eyes with active and inactive ocular involvement in BD and compared the results with age-matched controls.…”

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confidence: 99%