Increased cortical activation upon painful stimulation in fibromyalgia syndrome

Üçeyler, Nurcan; Zeller, Julia; Kewenig, Susanne; Kittel‐Schneider, Sarah; Fallgatter, Andreas J.; Sommer, Claudia

doi:10.1186/s12883-015-0472-4

Cited by 54 publications

(41 citation statements)

References 55 publications

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“…Post hoc analyses were performed for significant factors/interactions. For each channel, post hoc analyses were performed separately for significant factors/interactions by using Bonferroni correction as in previous studies (Schroeter, Zysset, Kupka, Kruggel, & Yves von Cramon, 2002;Uceyler et al, 2015). A p-value .05 was considered for statistical significance.…”

Section: Brain Activity Data Analysismentioning

confidence: 99%

Association of Fine Motor Loss and Allodynia in Fibromyalgia: An fNIRS Study

Eken

Gökçay

Yılmaz

et al. 2017

Journal of Motor Behavior

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Recent studies showed that fine motor control dysfunction was observed in fibromyalgia (FM) syndrome as well as allodynia. However, brain signatures of this association still remain unclear. In this study, finger tapping task (FTT) and median nerve stimulation (MNS) were applied to both hands of 15 FM patients and healthy controls (HC) to understand this relationship. Hemodynamic activity was measured simultaneously using functional near-infrared spectroscopy (fNIRS). Experiments were analyzed separately by using 2x2 repeated measures ANOVA. Results for the FTT experiment revealed that HC showed higher activity than FM patients in bilateral superior parietal gyrus (SPG), left supramarginal gyrus (SMG) and right somatosensory cortex (SI). Furthermore, right-hand FTT resulted in higher activity than left-hand FTT in left SPG, left SI and right motor cortex (MI). In the MNS experiment, FM patients showed higher activity than HC in bilateral SPG, right SMG, right SI and right middle frontal gyrus (MFG). Negative correlation was observed in left SPG between FTT and MNS activities. Besides, MNS activity in left SPG was negatively correlated with left-hand pain threshold.This study revealed that left SPG might be an important indicator to associate fine motor loss and allodynia in FM.

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Section: Brain Activity Data Analysismentioning

confidence: 99%

Association of Fine Motor Loss and Allodynia in Fibromyalgia: An fNIRS Study

Eken

Gökçay

Yılmaz

et al. 2017

Journal of Motor Behavior

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“…It has already confirmed strong correlations between the BOLD and NIRS signals . Üçeyler has also investigated further evidence for altered central nervous processing in patients with FM and the distinction between FM and major depression by using NIRS method . But these studies still focused on investigating pain‐associated cortical activity.…”

Section: Discussionmentioning

confidence: 91%

Altered near‐infrared spectroscopy response to breath‐holding in patients with fibromyalgia

Chen

Sun

2018

Journal of Biophotonics

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Fibromyalgia (FM) is a complex syndrome characterized by chronic widespread pain and a heightened response to pressure. Most medical researches pointed out that FM patients with endothelial dysfunction and arterial stiffness. A continuous-wave near-infrared spectroscopy (NIRS) system is used in present study to measure the hemodynamic changes elicited by breath-holding task in patients with FM. Each patient completed a questionnaire survey including demographics, characteristics of body pain, associated symptoms, headache profiles and Hospital Anxiety and Depression Scale. A total of 27 FM patients and 26 health controls were enrolled. In comparison with healthy controls, patients with FM showed lower maximal and averaged change of oxyhemoglobin concentration in both the left (1.634 ±0.890 and 0.810 ±0.525 μM) and the right (1.576 ±0.897 and 0.811 ±0.601 μM) prefrontal cortex than healthy controls (P < .05 for both sides) during the breath-holding task. In conclusion, FM is associated with altered cerebrovascular reactivity measured by NIRS and breath-holding task, which may reflect endothelial dysfunction or arterial stiffness. Oxygenated hemoglobin concentration changes of healthy controls and FM patients.

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“…Regarding the S1 area, recent work shows promising results for pain-specific hemodynamic changes assessed by fNIRS during noxious and innocuous stimulation of the thumb in healthy subjects . In addition, Uceyler et al (2015) reported enhanced cortical activity in the S1 in patients with fibromyalgia syndrome after painful pressure stimulation at the dorsal forearm. However, the lower back has not yet been a target for combined painful pressure stimulation and cortical hemodynamic changes measurements by means of fNIRS.…”

Section: Introductionmentioning

confidence: 98%

“…In addition, Uceyler et al. () reported enhanced cortical activity in the S1 in patients with fibromyalgia syndrome after painful pressure stimulation at the dorsal forearm. However, the lower back has not yet been a target for combined painful pressure stimulation and cortical hemodynamic changes measurements by means of fNIRS.…”

Section: Introductionmentioning

confidence: 99%

Different mechanosensory stimulations of the lower back elicit specific changes in hemodynamics and oxygenation in cortical sensorimotor areas—AfNIRSstudy

et al. 2016

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Background and ObjectivesThis study aimed at investigating the feasibility of functional near‐infrared spectroscopy (fNIRS) to measure changes in cerebral hemodynamics and oxygenation evoked by painful and nonpainful mechanosensory stimulation on the lower back. The main objectives were to investigate whether cortical activity can be (1) detected using functional fNIRS, and (2) if it is possible to distinguish between painful and nonpainful pressure as well as a tactile brushing stimulus based on relative changes in oxy‐ and deoxyhemoglobin ([O2Hb] and [HHb]).MethodsTwenty right‐handed subjects (33.5 ± 10.7 years; range 20–61 years; 8 women) participated in the study. Painful and nonpainful pressure stimulation was exerted with a thumb grip perpendicularly to the spinous process of the lumbar spine. Tactile stimulation was realized by a one‐finger brushing. The supplementary motor area (SMA) and primary somatosensory cortex (S1) were measured bilaterally using a multichannel continuous‐wave fNIRS imaging system.ResultsCharacteristic relative changes in [O2Hb] in the SMA and S1 after both pressure stimulations (corrected for multiple comparison) were observed. [HHb] showed only much weaker changes (uncorrected). The brushing stimulus did not reveal any significant changes in [O2Hb] or [HHb].ConclusionThe results indicate that fNIRS is sensitive enough to detect varying hemodynamic responses to different types of mechanosensory stimulation. The acquired data will serve as a foundation for further investigations in patients with chronic lower back pain. The future aim is to disentangle possible maladaptive neuroplastic changes in sensorimotor areas during painful and nonpainful lower back stimulations based on fNIRS neuroimaging.

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Increased cortical activation upon painful stimulation in fibromyalgia syndrome

Cited by 54 publications

References 55 publications

Association of Fine Motor Loss and Allodynia in Fibromyalgia: An fNIRS Study

Association of Fine Motor Loss and Allodynia in Fibromyalgia: An fNIRS Study

Altered near‐infrared spectroscopy response to breath‐holding in patients with fibromyalgia

Different mechanosensory stimulations of the lower back elicit specific changes in hemodynamics and oxygenation in cortical sensorimotor areas—AfNIRSstudy

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