2015
DOI: 10.1515/biolog-2015-0030
|View full text |Cite
|
Sign up to set email alerts
|

Increased endogenous serotonin level in diabetic conditions may lead to cardiac valvulopathy via reactive oxygen species regulation

Abstract: Diabetes mellitus (DM) is considered as a risk of cardiovascular diseases due to the expression of certain pathological factors, including hormones, such as serotonin. The aim of the current study was to evaluate the bridging role of serotonin between DM and cardiac valvulopathy via reactive oxygen species (ROS) generation. Eighty diabetic patients and 50 healthy individuals along with experimental models were studied. DM was induced in the rat model via intraperitoneal alloxan injection and subsequently treat… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2
1

Citation Types

0
6
0

Year Published

2020
2020
2024
2024

Publication Types

Select...
8
1
1

Relationship

5
5

Authors

Journals

citations
Cited by 14 publications
(6 citation statements)
references
References 46 publications
0
6
0
Order By: Relevance
“…TBARS level was estimated [ 55 ] to determine the damage to lipids caused by reactive oxygen species in various experimental groups. Briefly, 0.1 ml of sample, 0.1 ml FeSO 4 , 0.1 ml Tris-HCl, 0.6 ml distilled water, and 0.1 ml ascorbic acid were incubated at 37 °C in a test tube 15 min, and then 1 ml TCA and 2 ml TBA were added.…”
Section: Methodsmentioning
confidence: 99%
“…TBARS level was estimated [ 55 ] to determine the damage to lipids caused by reactive oxygen species in various experimental groups. Briefly, 0.1 ml of sample, 0.1 ml FeSO 4 , 0.1 ml Tris-HCl, 0.6 ml distilled water, and 0.1 ml ascorbic acid were incubated at 37 °C in a test tube 15 min, and then 1 ml TCA and 2 ml TBA were added.…”
Section: Methodsmentioning
confidence: 99%
“…Thiobarbituric acid reactive substance (TBARs) level was estimated (Ali T. et al, 2015) to determine the damage to lipids caused by ROS in various experimental groups. Briefly, 0.1 ml of sample (Hippocampal tissue immunomodulatory), 0.1 ml FeSO4, 0.1 ml Tris-HCl, 0.6 ml distilled water, and 0.1 ml Ascorbic Acid were incubated at 37 • C in a test tube for 15 min and then 1 ml TCA and 2 ml TBA were added.…”
Section: Tbars Assaymentioning
confidence: 99%
“…For lipid analysis, extraction was performed on the samples using petroleum ether. The percentage of crude lipid was determined using the Soxhlet apparatus, following the methods described by Hafiz et al 18 .…”
Section: Methodsmentioning
confidence: 99%