Increased erythrocyte aggregation in ovarian hyperstimulation syndrome: a possible contributing factor in the pathophysiology of this disease

Levin, Ishai; Gamzu, Ronni; Hasson, Y.; Lessing, Joseph B.; Amit, Ami; Shapira, Itzhak; Berliner, Shlomo; Almog, Benny

doi:10.1093/humrep/deh210

Cited by 13 publications

(7 citation statements)

References 26 publications

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“…16,17 Routine laboratory tests showed higher levels of platelets, fibrinogen, and WBC in these patients. 18,19 However, few studies assessed overall clotting function. Whole blood clotting time and clot formation were shortened in women undergoing ART, and the differences did not, however, achieve a statistical significance.…”

Section: Discussionmentioning

confidence: 99%

A New Perspective on the Risk of Hypercoagulopathy in Ovarian Hyperstimulation Syndrome Using Thromboelastography

et al. 2017

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Thromboelastography (TEG) provides real-time assessment of hemostasis by measuring the viscoelastic properties, coagulation factor, and platelet activity in whole blood samples. In this prospective case-control study, we wanted to investigate whether blood clot formation assessment, using TEG, can identify a hypercoagulable state in women with severe ovarian hyperstimulation syndrome (OHSS). Thirty-six women who were hospitalized with severe OHSS were allocated to the OHSS group and 32 women undergoing controlled ovarian hyperstimulation but who did not develop OHSS were allocated to the control group. The TEG indices were compared between women with severe OHSS and controls. All the coagulation indices assessed by TEG were significantly different in the OHSS group compared to the controls, depicting a hypercoagulable state. Median coagulation index was 3.6 (interquartile range: 2.80-4.15) and 1.45 (interquartile range: 0.20-2.30) in study group and controls, respectively ( P < .001). Our results show that TEG can be used to depict a hypercoagulable state in women with severe OHSS.

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Section: Discussionmentioning

confidence: 99%

A New Perspective on the Risk of Hypercoagulopathy in Ovarian Hyperstimulation Syndrome Using Thromboelastography

et al. 2017

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“…Thus, the erythrocytes, which are kept in their native milieu, surrounded by the various sticky proteins, are used to sense the effect of this stickiness [32,33]. This is the essence of the ERYTHROSENSE methodology and has been repeatedly shown (although by using another way of measuring the degree of cell adhesiveness/aggregation) to correlate significantly with the degree of inflammation [34] as well as the markers of the acute-phase response [35,36].…”

Section: Discussionmentioning

confidence: 99%

Association of components of the metabolic syndrome with the appearance of aggregated red blood cells in the peripheral blood. An unfavorable hemorheological finding

Toker

Rogowski

Melamed

et al. 2005

Diabetes Metab. Res. Rev.

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“…We recently conducted a study to define the degree of erythrocyte aggregation in women with OHSS and women with controlled ovarian hyperstimulation (COH) 11 . In this study, we used an assay for the determination of high sensitivity C‐reactive protein (hs‐CRP) concentrations in order to determine whether patients with OHSS demonstrate increased levels of this protein in their peripheral blood.…”

Section: Introductionmentioning

confidence: 99%

Elevated levels of CRP in ovarian hyperstimulation syndrome: an unrecognised potential hazard?

Levin

Gamzu

Pauzner

et al. 2005

BJOG

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Objective Elevated levels of C-reactive protein (CRP) were found recently to be a crucial marker for cardiovascular disease. This protein might have a role in endothelial cell activation, vascular damage and a thrombotic tendency. We sought to determine whether concentrations of CRP are altered in women with controlled ovarian hyperstimulation (COH) or hyperstimulation syndrome (OHSS). Design A prospective cohort study.Setting The gynecology department and IVF unit of the Lis maternity hospital.Population Twenty women with OHSS, 20 women undergoing COH and 20 women who participated as controls were included in the study. Methods Venous blood was withdrawn for analysis of high sensitive C-reactive protein (hs-CRP) using the Boering BN-II nephelometer. Main outcome measures hs-CRP levels were determined.Results There was a significant (P < 0.05) difference in the hs-CRP concentrations in women with OHSS compared with women with COH and controls.

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Increased erythrocyte aggregation in ovarian hyperstimulation syndrome: a possible contributing factor in the pathophysiology of this disease

Abstract: The degree of erythrocyte aggregation is enhanced in the peripheral venous blood of patients with both COH and OHSS. This finding, known to cause capillary leak, may contribute to the pathophysiology of the OHSS.

Cited by 13 publications

References 26 publications

A New Perspective on the Risk of Hypercoagulopathy in Ovarian Hyperstimulation Syndrome Using Thromboelastography

A New Perspective on the Risk of Hypercoagulopathy in Ovarian Hyperstimulation Syndrome Using Thromboelastography

Association of components of the metabolic syndrome with the appearance of aggregated red blood cells in the peripheral blood. An unfavorable hemorheological finding

Elevated levels of CRP in ovarian hyperstimulation syndrome: an unrecognised potential hazard?

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