Increased expression of a cGMP-dependent protein kinase in rotation-adapted western corn rootworm (Diabrotica virgifera virgifera L.)

Garabagi, Freydoun; French, B. Wade; Schaafsma, A. W.; Pauls, K. Peter

doi:10.1016/j.ibmb.2008.03.011

Cited by 10 publications

(19 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In some cases, natural variation in a single gene can be identified that affects the regulation of complex yet distinct behavior patterns (e.g., de Bono and Bargmann, 1998;Krieger and Ross, 2002;Davies et al, 2004;Hammock, 2007). Interestingly, a number of recent achievements in this area involve food-related behaviors and the foraging gene, which encodes a cGMP-dependent protein kinase (PKG) (Osborne et al, 1997;Ben-Shahar et al, 2002Hirose et al, 2003;Fitzpatrick and Sokolowski, 2004;Ingram et al, 2005;Fussnecker and Grozinger, 2008;Garabagi et al, 2008;Heylen et al, 2008;Lucas et al, 2009;Lucas and Sokolowski, 2009).…”

Section: Introductionmentioning

confidence: 99%

The locust foraging gene

Lucas

Kornfein

Chakaborty-Chatterjee

et al. 2010

Arch Insect Biochem Physiol

View full text Add to dashboard Cite

Our knowledge of how genes act on the nervous system in response to the environment to generate behavioral plasticity is limited. A number of recent advancements in this area concern food-related behaviors and a specific gene family called foraging (for), which encodes a cGMPdependent protein kinase (PKG). The desert locust (Schistocerca gregaria) is notorious for its destructive feeding and long-term migratory behavior. Locust phase polyphenism is an extreme example of environmentally induced behavioral plasticity. In response to changes in population density, locusts dramatically alter their behavior, from solitary and relatively sedentary behavior to active aggregation and swarming. Very little is known about the molecular and genetic basis of this striking behavioral phenomenon. Here we initiated studies into the locust for gene by identifying, cloning, and studying expression of the gene in the locust brain. We determined the phylogenetic relationships between the locust PKG and other known PKG proteins in insects. FOR expression was found to be confined to neurons of the anterior midline of the brain, the pars intercerebralis. Our results suggest that differences in PKG enzyme activity are correlated to well-established phase-related behavioral differences. These results lay the groundwork for functional studies of the locust for gene and its possible relations to locust phase polyphenism.

show abstract

Section: Introductionmentioning

confidence: 99%

The locust foraging gene

Lucas

Kornfein

Chakaborty-Chatterjee

et al. 2010

Arch Insect Biochem Physiol

View full text Add to dashboard Cite

show abstract

“…, ; Lucas & Sokolowski ), locusts (Newland & Yates ), beetles (Garabagi et al . ), and even beyond the order Insecta, in several nematode species (Fujiwara et al . ; Hong et al .…”

Section: Exploring Molecular Mechanisms Behind Invertebrate Behaviourmentioning

confidence: 99%

Walking with insects: molecular mechanisms behind parasitic manipulation of host behaviour

2013

View full text Add to dashboard Cite

Parasitic infections are often followed by changes in host behaviour. Numerous and exquisite examples of such behavioural alterations are known, covering a broad spectrum of parasites and hosts. Most descriptions of such parasite-induced changes in host behaviour are observational reports, while experimentally confirmed examples of parasite genes inducing these changes are limited. In this study, we review changes in invertebrate host behaviour observed upon infection by parasites and discuss such changes in an evolutionary context. We then explore possible mechanisms involved in parasite-induced changes in host behaviour. Genes and pathways known to play a role in invertebrate behaviour are reviewed, and we hypothesize how parasites (may) affect these pathways. This review provides the state of the art in this exciting, interdisciplinary field by exploring possible pathways triggered in hosts, suggesting methodologies to unravel the molecular mechanisms that lead to changes in host behaviour.

show abstract

“…PKG signalling was shown to have several important functions in animal behaviour, including aggressive and sexual behaviour in mammals (for a review, see Hofmann et al, ), food‐searching behaviour in insects and mediation of nutritional status in C. elegans . In social insects, this enzyme furthermore seems to have a pivotal role in the modulation of the transition between different behavioural states (Pereira and Sokolowski, ; Fujiwara et al, ; Ingram et al, ; Garabagi et al, ; Lucas et al, ; Tobback et al, ). Our results provide evidence that PKG protein content but not PKG enzyme activity correlates with the nurse–forager transition in honeybees, which seems to be independent of nutritional state.…”

Section: Discussionmentioning

confidence: 99%

Levels and activity of cyclic guanosine monophosphate‐dependent protein kinase in nurse and forager honeybees

Thamm

Sturm

Schlossmann

et al. 2018

Insect Molecular Biology

View full text Add to dashboard Cite

Age-dependent division of labour in honeybees was shown to be connected to sensory response thresholds. Foragers show a higher gustatory responsiveness than nurse bees. It is generally assumed that nutrition-related signalling pathways underlie this behavioural plasticity. Here, one important candidate gene is the foraging gene, which encodes a cyclic guanosine monophosphate-dependent protein kinase (PKG). Several roles of members of this enzyme family were analysed in vertebrates. They own functions in important processes such as growth, secretion and neuronal adaptation. Honeybee foraging messenger RNA expression is upregulated in the brain of foragers. In vivo activation of PKG can modulate gustatory responsiveness. We present for the first time PKG protein level and activity data in the context of social behaviour and feeding. Protein level was significantly higher in brains of foragers than in those of nurse bees, substantiating the role of PKG in behavioural plasticity. However, enzyme activity did not differ between behavioural roles. The mediation of feeding status appears independent of PKG signalling. Neither PKG content nor enzyme activity differed between starved and satiated individuals. We suggest that even though nutrition-related pathways are surely involved in controlling behavioural plasticity, which involves changes in PKG signalling, mediation of satiety itself is independent of PKG.

show abstract

Increased expression of a cGMP-dependent protein kinase in rotation-adapted western corn rootworm (Diabrotica virgifera virgifera L.)

Cited by 10 publications

References 34 publications

The locust foraging gene

The locust foraging gene

Walking with insects: molecular mechanisms behind parasitic manipulation of host behaviour

Levels and activity of cyclic guanosine monophosphate‐dependent protein kinase in nurse and forager honeybees

Contact Info

Product

Resources

About