Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis

Wang, Xiaowei; Cai, Changjie; Xu, Jingming; Jin, Hai; Zhao, Xu

doi:10.1007/s13277-014-2690-6

Cited by 27 publications

(16 citation statements)

References 23 publications

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“…In addition, the MVD in HCC tissues was significantly higher compared with tumor-adjacent and normal liver tissues. These results suggest that Ang-1 is important for microvessel formation in HCC, which is consistent with the results of previous studies (18)(19)(20)(21).…”

Section: Discussionsupporting

confidence: 93%

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Importance of activated hepatic stellate cells and angiopoietin-1 in the pathogenesis of hepatocellular carcinoma

Lin

Meng

et al. 2016

Molecular Medicine Reports

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Previous studies have determined that activated hepatic stellate cells (aHSCs) promote the progression of hepatocellular carcinoma (HCC) by increasing angiogenesis in cancerous tissues. In addition, angiopoietin 1 (Ang‑1) has been reported to be involved in tumor growth and metastasis via the promotion of angiogenesis. It remains unclear whether aHSCs and Ang‑1 are involved in the angiogenesis in HCC. A total of 25 HCC and tumor‑adjacent tissues, and 21 normal liver tissues were used in the present study. Immunohistochemistry (IHC) was used to detect the expression of Ang‑1 and α smooth muscle actin (α‑SMA). The expression of CD34 was also analyzed using IHC to evaluate the microvessel density (MVD). The protein expression levels of Ang‑1 were evaluated using western blot analysis. The association between aHSC, Ang‑1 and angiogenesis was determined using Spearman's rank correlation coefficient. The present study determined that the expression of α‑SMA, Ang‑1 and MVD (CD34) was significantly higher in the HCC tissues when compared with tumor‑adjacent tissues and normal liver tissues. Spearman's rank analysis identified a positive correlation between the expression of α‑SMA, Ang‑1 and CD34. This suggests that α‑SMA‑positive aHSCs promoted angiogenesis by expressing Ang‑1, resulting in the proliferation and metastasis of HCC.

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Section: Discussionsupporting

confidence: 93%

“…The MVD (CD34) in HCC, tumor-adjacent and normal liver tissues was determined using IHC analysis of CD34 as previously described (18)(19)(20)(21). CD34-positive cells were predominantly detected in the cancer cell nest and hepatic blood sinus (Fig.…”

Section: Mvd In Hcc Tumor-adjacent and Normal Liver Tissuesmentioning

confidence: 99%

Importance of activated hepatic stellate cells and angiopoietin-1 in the pathogenesis of hepatocellular carcinoma

Lin

Meng

et al. 2016

Molecular Medicine Reports

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“…In the 3 articles about urogenital system cancer using OS to assess clinical outcome, the combined HR 1.31 (95% CI: 0.91-1.87, P = 0.144), implying the association between overexpression of YKL-40 and poor OS was not signi cant ( Figures S1). Interestingly, the heterogeneity showed a remarkable change in the research region Ykl-40 And Dfs DFS data were reported or extrapolated from 11 studies, representing a total of 2092 patients (26,27,29,32,37,41,43,(45)(46)(47)(48)(49). The pooled HR and 95%CI was calculated by using a xed-effects model, heterogeneities between HR estimates was no signi cantly in this meta-analysis (I 2 = 18.6; P = 0.267).…”

Section: Characteristics and Quality Assessment Of The Included Studiesmentioning

confidence: 80%

CHI3L1 Expression is a Prognostic Marker for Patients with Diagnosed Solid Tumors: Evidence from a Systematic Review and Meta-Analysis

Pan¹,

Wu²,

Yin³

et al. 2020

Preprint

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Background: Accumulating studies have demonstrated YKL-40 associated with the prognosis of several cancers and contributed to the tumor progression through promoting tumor angiogenesis, migration, invasion and metastasis. The objective of this meta-analysis was to investigatethe relationship between YKL-40 and prognosis inpatients with solid tumors and seek for a new prognostic biomarker.Method: Relevant studies were searched in the Medline (PubMed), Web of science, and Embase. Pooled HR of overall survival and disease-free survival (DFS) were calculated to evaluate the strengthof the association between YKL-40 and cancer prognosis by using Stata software 14.0.Results: In total, 30 studies comprising 5160 patients were considered eligible and enrolled into the final meta-analysis. According to the meta-analysis results, higher expression of YKL-40 predicted poorer OS (pooled HR=1.85 CI%=1.58-2.18；P<0.001) and DFS (pooled HR =3.63 95% CI =2.63-5.01; P<0.001).Conclusion: The current evidence suggests that YKL-40 has a predictive effect onsurvival of cancer patients as indexed by DFS and OS. YKL-40 tissue expression is a valuable prognostic biomarker and may be a promising therapeutic target for solid tumors.

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“…YKL-40, additionally termed CHI3L1, is produced by a variety of cells (10), including macrophages, neutrophils, eosinophils, vascular smooth muscle cells, endothelial cells and cancer cells. Elevated levels of serum YKL-40 protein have been reported in a number of other types of cancer, including glioma (11) cholangiocarcinoma (12), colorectal cancer (13), non-small cell lung cancer (14), renal cell cancer (15) and osteosarcoma (16). YKL-40 may also be expressed within local inflammatory cells in inflamed tissues (17,18) and it is considered to be a biomarker in inflammatory disease.…”

Section: Discussionmentioning

confidence: 99%

Influence of YKL‑40 gene RNA interference on the biological behaviors of endometrial cancer HEC‑1A cells

Fan

et al. 2018

Oncol Lett

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The present study aimed to investigate the effects of chitinase-3-like protein 1 (YKL-40) gene RNA interference on the biological behaviors and enhanced chemosensitivity of endometrial cancer (EC) HEC-1A cells. YKL-40 small interfering (si)RNA was transduced into EC HEC-1A cells using a lentivirus. The experiment was divided into three groups: The experimental group was transfected with YKL-40 siRNA (si-YKL-40); the mock-treatment group was transfected with transfection reagent only; and the blank control group was left untreated. A reverse transcription-quantitative polymerase chain reaction was performed to investigate the mRNA expression levels of YKL-40. The biological behaviors, including cell proliferation, migration, invasion and apoptosis, were detected by MTT and Transwell assays, and flow cytometry (FCM) analysis, respectively. The results of the present study demonstrated that the mRNA expression levels of YKL-40 were downregulated within HEC-1A cells upon transfection with si-YKL-40 (P<0.05). The proliferative, migratory and invasive abilities of HEC-1A cells were inhibited by si-YKL-40 (P<0.05). The mRNA expression levels of YKL-40 were upregulated within HEC-1A cells following treatment with cisplatin (P<0.05). FCM analysis revealed that the average cellular apoptosis rate increased following the inhibition of YKL-40 gene expression via siRNA (P<0.05). Therefore, the YKL-40 gene may be associated with the proliferative, migratory, invasive and anti-apoptotic ability of HEC-1A cells. YKL-40 downregulation may enhance the sensitivity of human EC HEC-1A cells to chemotherapy.

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Increased expression of chitinase 3-like 1 is a prognosis marker for non-small cell lung cancer correlated with tumor angiogenesis

Cited by 27 publications

References 23 publications

Importance of activated hepatic stellate cells and angiopoietin-1 in the pathogenesis of hepatocellular carcinoma

Importance of activated hepatic stellate cells and angiopoietin-1 in the pathogenesis of hepatocellular carcinoma

CHI3L1 Expression is a Prognostic Marker for Patients with Diagnosed Solid Tumors: Evidence from a Systematic Review and Meta-Analysis

Influence of YKL‑40 gene RNA interference on the biological behaviors of endometrial cancer HEC‑1A cells

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