Increased Expression of Endogenous Xenotropic Murine Retrovirus by Treatment with the Tetrapeptides, Tuftsin and Kentsin

Suk, William A.; Long, Cedric

doi:10.1099/0022-1317-52-1-189

Cited by 8 publications

References 21 publications

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Beeinflußt Dipeptidylpeptidase IV Blutdruck und Gerinnung?

Heymann

Mentlein

1984

Klin Wochenschr

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Dipeptidyl peptidase IV is a very specific protease that attracts growing scientific interest during the last few years. The enzyme has been purified to homogeneity from various human tissues. Histochemically, this protease is found at certain border lines of many organ compartments, as in the proximal tubuli of kidney, in the bile canaliculi of liver, in the capillary endothel, or in the myofibroblasts of placenta. In the blood, especially T-helper lymphocytes contain this enzyme. Dipeptidyl peptidase IV seems to be predestinated for regulatory functions, because it is located on the outer membranes of these cells. The peptidase very specifically degrades substance P. Thus, it is discussed whether the system substance P/dipeptidyl peptidase IV is involved in the regulation of blood pressure, especially in the placenta. On the other hand, the specific attack of the peptidase on the alpha-chain of monomeric fibrin considerably reduces the clotting potency of these molecules. Therefore, dipeptidyl peptidase IV may also be involved in the regulation of blood coagulation in intact vessels, especially because the capillary endothel is lined with this enzyme. The plasma zinc concentration seems to influence the peptidase activity. An increase in plasma zinc stimulates various factors that promote blood clotting.

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Beeinflußt Dipeptidylpeptidase IV Blutdruck und Gerinnung?

Heymann

Mentlein

1984

Klin Wochenschr

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Induction of endogenous xenotropic retrovirus expression by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate

Suk

Long

1986

In Vitro Cell Dev Biol

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The tumor promotor 12-O-tetradecanoylphorbol-13-acetate (TPA) was examined for its ability to induce endogenous retrovirus from a high-passage clone of Kirsten sarcoma virus-transformed Balb/c (K-Balb) mouse cells. TPA activated virus in a concentration-dependent manner (0.0016 to 4.0 microM). Exposure to 1mM actinomycin D inhibited virus induction, suggesting that cellular RNA synthesis is required de novo by this inducer. A broad-spectrum neutralizing antibody to murine type C virus, gp70, was shown to neutralize the infectivity of the induced virus. The activated virus had the host range of the xenotropic Balb virus:2, and after removal of the inducer, the activated state decayed rapidly. TPA stimulated DNA, RNA, and protein synthesis in K-Balb cells, indicating that the mechanism of induction may be different from that of previously identified virus inducers. The effects observed using the well-defined K-Balb system offer an opportunity to study the modulation of retrovirus gene expression by TPA.

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Tuftsin (Thr-Lys-Pro-Arg): A Natural Activator of Phagocytic Cells with Antibacterial and Antineoplastic Activity

Najjar

1985

Biological Response Modifiers

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Increased Expression of Endogenous Xenotropic Murine Retrovirus by Treatment with the Tetrapeptides, Tuftsin and Kentsin

Cited by 8 publications

References 21 publications

Beeinflußt Dipeptidylpeptidase IV Blutdruck und Gerinnung?

Beeinflußt Dipeptidylpeptidase IV Blutdruck und Gerinnung?

Induction of endogenous xenotropic retrovirus expression by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate

Tuftsin (Thr-Lys-Pro-Arg): A Natural Activator of Phagocytic Cells with Antibacterial and Antineoplastic Activity

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