Increased expression of proline-, glutamic acid- and leucine-rich protein PELP1 in non-small cell lung cancer

Słowikowski, Bartosz Kazimierz; Gałęcki, Bartłomiej; Dyszkiewicz, Wojciech; Jagodzińśki, Paweł P.

doi:10.1016/j.biopha.2015.05.015

Cited by 16 publications

(18 citation statements)

References 31 publications

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“…In triple‐negative breast cancer (TNBC), dual expression of PELP1/Ki‐67 is an independent prognostic factor for predicting the poorer outcome . PELP1 expression levels were upregulated in non–small cell lung cancer and correlated with the degree of malignancy . Furthermore, ESR2‐PELP1 axis has shown to play an essential role in colorectal tumorigenesis and might have prognostic significance .…”

Section: Discussionmentioning

confidence: 99%

“…30 PELP1 expression levels were upregulated in non-small cell lung cancer and correlated with the degree of malignancy. 21 Furthermore, ESR2-PELP1 axis has shown to play an essential role in colorectal tumorigenesis and might have prognostic significance. 31 PELP1 is overexpressed in astrocytic tumors in a small cohort of patients and serve as a prognostic biomarker.…”

Section: Discussionmentioning

confidence: 99%

“…PELP1 is essential for estrogen‐mediated neuroprotective and cognitive functions in the brain via modulation of cellular survival, antioxidant, and inflammatory pathways . Several recent studies have identified that PELP1 is overexpressed in multiple cancer types including breast, prostate, ovarian, colon, pancreas, lung, endometrial, and salivary . However, the role and significance of PELP1 in MB remain unknown.…”

Section: Introductionmentioning

confidence: 99%

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PELP1 signaling contributes to medulloblastoma progression by regulating the NF‐κB pathway

Luo

Pratap

et al. 2019

Molecular Carcinogenesis

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Medulloblastoma (MB) is the most common and deadliest brain tumor in children. Proline‐, glutamic acid‐, and leucine‐rich protein 1 (PELP1) is a scaffolding protein and its oncogenic signaling is implicated in the progression of several cancers. However, the role of PELP1 in the progression of MB remains unknown. The objective of this study is to examine the role of PELP1 in the progression of MB. Immunohistochemical analysis of MB tissue microarrays revealed that PELP1 is overexpressed in the MB specimens compared to normal brain. Knockdown of PELP1 reduced cell proliferation, cell survival, and cell invasion of MB cell lines. The RNA‐sequencing analysis revealed that PELP1 knockdown significantly downregulated the pathways related to inflammation and extracellular matrix. Gene set enrichment analysis confirmed that the PELP1‐regulated genes were negatively correlated with nuclear factor‐κB (NF‐κB), extracellular matrix, and angiogenesis gene sets. Interestingly, PELP1 knockdown reduced the expression of NF‐κB target genes, NF‐κB reporter activity, and inhibited the nuclear translocation of p65. Importantly, the knockdown of PELP1 significantly reduced in vivo MB progression in orthotopic models and improved the overall mice survival. Collectively, these results suggest that PELP1 could be a novel target for therapeutic intervention in MB.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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PELP1 signaling contributes to medulloblastoma progression by regulating the NF‐κB pathway

Luo

Pratap

et al. 2019

Molecular Carcinogenesis

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“…Overexpression of PELP1 in the mammary gland using transgenic mice model contributed to mammary gland carcinoma, further supporting its oncogenic potential in vivo (Cortez et al 2014). PELP1 oncogenic signaling is implicated in progression of several cancers including breast (Krishnan et al 2015; Zhang et al 2015), endometrial (Vadlamudi et al 2004) ovarian (Chakravarty 2008), salivary (Vadlamudi et al 2005a), prostate (Yang et al 2012), lung (Slowikowski et al 2015), pancreas (Kashiwaya et al 2010) and colon (Ning et al 2014). …”

Section: Functions Of Pelp1 In Cancermentioning

confidence: 99%

“…PELP1 phosphorylation at the ATM target site was significantly greater in the TNBC tumors than in the other subtypes of breast cancer and in the normal tissues (Krishnan et al 2015). The PELP1 transcript and protein increase in non-small cell lung cancer and correlates with stage (Slowikowski et al 2015). Studies using ovarian tumor tissue arrays revealed that PELP1 is over expressed twofold to threefold in 60% of ovarian neoplasia (Dimple et al 2008).…”

Section: Prognostic Significance Of Pelp1mentioning

confidence: 99%

PELP1: Structure, biological function and clinical significance

Sareddy

Vadlamudi

2016

Gene

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Proline-, glutamic acid-, and leucine-rich protein 1 (PELP1) is a scaffolding protein that functions as a coregulator of several transcription factors and nuclear receptors. Notably, the PELP1 protein has a histone-binding domain, recognizes histone modifications and interacts with several chromatin-modifying complexes. PELP1 serves as a substrate of multitude of kinases, and phosphorylation regulates its functions in various complexes. Further, PELP1 plays essential roles in several pathways including hormonal signaling, cell cycle progression, ribosomal biogenesis, and the DNA damage response. PELP1 expression is upregulated in several cancers, its deregulation contributes to therapy resistance, and it is a prognostic biomarker for breast cancer survival. Recent evidence suggests that PELP1 represents a novel therapeutic target for many hormonal cancers. In this review, we summarized the emerging biological properties and functions of PELP1.

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PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug

Wang

Yin

2022

Pathology - Research and Practice

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Increased expression of proline-, glutamic acid- and leucine-rich protein PELP1 in non-small cell lung cancer

Cited by 16 publications

References 31 publications

PELP1 signaling contributes to medulloblastoma progression by regulating the NF‐κB pathway

PELP1 signaling contributes to medulloblastoma progression by regulating the NF‐κB pathway

PELP1: Structure, biological function and clinical significance

PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug

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