Increased fibroblast proliferation and activity after applying intense pulsed light 800–1200nm

Cuerda-Galindo, Esther; Dı́az-Gil, Gema; Palomar-Gallego, María A.; Linares-García-Valdecasas, Rafael

doi:10.1016/j.aanat.2014.11.005

Cited by 29 publications

(17 citation statements)

References 55 publications

(52 reference statements)

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“…Although it is well established that MMP expression was increased in damaged or photoaged skin [38,39], Cuerda-Galindo observed MMP-1 increased following IPL irradiation, consistent with the previous findings induced by laser treatment [40,41]. Based on the above theories, these authors speculate that increased MMP could be an overlooked mechanism of skin rejuvenation, in which it will be implicated, contributing to the degradation of senescent collagens and then the turnover of the ECM [35]. So, it is reasonable that upregulation of MMPs levels following IPL irradiation did not contradict with the photorejuvenation effects and upregulation of collagen levels.…”

Section: In Vitro Effects Of Ipl On Fibroblasts Cytokines Etcsupporting

confidence: 77%

“…Among the noncollagenous components of the dermis, there are proteoglycans (PG), glycosaminoglycan conjugated proteins (GAG), hyaluronic acid, and versican, which are important constituents of human skin connective tissue and essential for maintaining mechanical strength of the skin. A study by Cuerda-Galindo detected an increase in the amount of collagens, accompanied by an elevation in protein production of hyaluronic acid and versican, which can be a possible mechanism of action for IPL devices in aging skin treatment [35,37].…”

Section: In Vitro Effects Of Ipl On Fibroblasts Cytokines Etcmentioning

confidence: 99%

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Intense Pulsed Light Therapy

Gu¹,

Liu²,

Liu³

2017

Photomedicine - Advances in Clinical Practice

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Intense pulsed light (IPL) is one of the most effective nonablative approaches to treat skin photoaging. The broad range of wavelengths (500-1200 nm) emitted from IPL devices effectively target both melanin and hemoglobin in the skin. Numerous trials show the effectiveness and compatibility of IPL devices in a variety of skin conditions, especially in cosmetic indications such as hypertrichosis and telangiectasias. Compared with the wide clinical use of IPL, the biochemical and molecular mechanism is not clear. Both in vivo and in vitro studies demonstrate that IPL could increase the production of extracellular matrix, promote the proliferation of fibroblasts, and increase the secretion of TGF-β and matrix metalloproteinases, which play important roles in the photorejuvenation effects of IPL. However, investigations regarding the detailed underlying mechanism are necessary.

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Section: In Vitro Effects Of Ipl On Fibroblasts Cytokines Etcsupporting

confidence: 77%

Section: In Vitro Effects Of Ipl On Fibroblasts Cytokines Etcmentioning

confidence: 99%

Intense Pulsed Light Therapy

Gu¹,

Liu²,

Liu³

2017

Photomedicine - Advances in Clinical Practice

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show abstract

“…An in vitro study showed that a pulsed 660 nm (LED) light enhanced collagen production in a tissue-engineered reconstructed skin model 37. In another in vitro study, irradiation of skin fibroblasts with IPL (800–1,200 nm) increased the proliferation rate of fibroblasts and increased the expression of collagen genes 38. These results are also supported by clinical studies 39…”

Section: Activating Fibroblasts and Enhancing Collagen Synthesismentioning

confidence: 70%

Intense pulsed light for evaporative dry eye disease

Dell¹

2017

OPTH

105

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There is a clear association between dry eye disease (DED) and skin inflammatory diseases occurring in close proximity to the eyelids, such as facial skin rosacea. Intense pulsed light (IPL) is widely accepted as a treatment for skin rosacea. A number of recent studies demonstrated that, in patients suffering from meibomian gland dysfunction (MGD), IPL therapy also reduces signs and symptoms of DED. Despite these encouraging results, in the context of DED and MGD, the mechanisms of action of IPL are not well understood. The purpose of this review was to raise the potential mechanisms of action and to discuss their plausibility.

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“…By treating rosacea, this obstruction can be considerably reduced. Other explanations include facilitating expression by softening the meibum as a result of heat transfer to the eyelids and meibomian glands;13 upregulating anti-inflammatory molecules, such as interleukins;34 augmenting the production of collagen by stimulating fibroblasts;35 and eradicating Demodex mites,36 which thrive on rosacea skin and are infested with Bacillus olerinus 37. This would have the indirect effect on decreasing the bacterial load on the eyelids.…”

Section: Discussionmentioning

confidence: 99%

Prospective evaluation of intense pulsed light and meibomian gland expression efficacy on relieving signs and symptoms of dry eye disease due to meibomian gland dysfunction

Dell¹,

Gaster²,

Barbarino³

et al. 2017

OPTH

121

115

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PurposeThe aim of this study was to estimate the efficacy of intense pulsed light (IPL), followed by meibomian gland expression (MGX), for reducing the number and severity of signs and symptoms of dry eye disease (DED) secondary to meibomian gland dysfunction (MGD).Patients and methodsIn a prospective study conducted in two sites, 40 subjects (80 eyes) with moderate to severe MGD were enrolled. Major inclusion criteria consisted of at least two of the following measures being compatible with DED in both eyes: tear breakup time (TBUT), meibomian gland score (MGS), corneal fluorescein staining (CFS), Standard Patient Evaluation of Eye Dryness (SPEED) questionnaire, and tear film osmolarity (TFO). Enrolled patients underwent four treatment sessions, 3 weeks apart. Each treatment included the administration of 10–15 pulses of IPL on the cheeks and nose, followed by MGX of the upper and lower eyelids. TBUT, MGS, CFS, SPEED, TFO, and lipid layer thickness (LLT) were measured at baseline (BL) and at 9, 12, and 15 weeks after BL.ResultsDue to different staining methods used for TBUT measurements, TBUT and CFS were analyzed separately for each site. From BL to the final follow-up, the number of signs compatible with DED decreased from 3.3±0.1 to 1.4±0.1. TBUT improved by +93% (n=38; P<0.0001) and +425% (n=42; P<0.0001) for sites 1 and 2, respectively. SPEED, MGS, and CFS improved by −55% (n=80; P<0.0001), −36% (n=80; P<0.0001), and −58% (n=38; P<0.0001), respectively. In 20 eyes with abnormally elevated TFO at BL, TFO improved by −7% (n=20; P<0.005). LLT did not change (n=38; P=0.88).ConclusionIn subjects with moderate to severe MGD, IPL combined with MGX reduced the number and severity of symptoms and signs of DED. Except for LLT, all examined outcome measures significantly improved after 15 weeks. These results support the efficacy of IPL + MGX in relieving both signs and symptoms of DED secondary to MGD.

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Increased fibroblast proliferation and activity after applying intense pulsed light 800–1200nm

Cited by 29 publications

References 55 publications

Intense Pulsed Light Therapy

Intense Pulsed Light Therapy

Intense pulsed light for evaporative dry eye disease

Prospective evaluation of intense pulsed light and meibomian gland expression efficacy on relieving signs and symptoms of dry eye disease due to meibomian gland dysfunction

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