Increased FURIN expression in rheumatoid arthritis patients and its anti‐inflammatory effect

Cao, Rong; Zhang, Ying; Du, Jing; Chen, Shuaishuai; Wang, Na; Hu, Yan; Shen, Bo

doi:10.1002/jcla.23530

Cited by 14 publications

(6 citation statements)

References 25 publications

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“…Although the exact cause is not known, furin levels were found to be higher in diabetic, elderly, smokers, and male SARS-CoV-2 patients. 35 However, contrary to our findings, no correlation was found between furin and IL-6 levels in patients with rheumatoid arthritis. 35 Although inflammation occurs in both diseases, etiological reasons are different.…”

Section: Discussioncontrasting

confidence: 99%

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Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2–infected patients

Koçyiğit

Söğüt²,

Durmuş

et al. 2021

Science Progress

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Coronavirus disease 2019 (COVID-19) is an infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in a vast number of infections and deaths that deeply affect the world. When the virus encounters the host cell, it binds to angiotensin-converting enzyme 2, then the S protein of the virus is broken down by the transmembrane protease serine 2 with the help of furin, allowing the virus to enter the cell. The elevated inflammatory cytokines suggest that a cytokine storm, also known as cytokine release syndrome, may play a major role in the pathology of COVID-19. Therefore, the aim of this study is to investigate the relationship between circulating furin levels, disease severity, and inflammation in patients with SARS-CoV-2. A total of 52 SARS-CoV-2 patients and 36 healthy control participants were included in this study. SARS- CoV-2 patients were scored by the disease activity score. Serum furin, presepsin, and interleukin-6 (IL-6) levels were assessed using an enzyme-linked immunosorbent assay. The mean furin, presepsin, and IL-6 levels were significantly higher in the peripheral blood of SARS-CoV-2 compared to the controls ( p < 0.001). There were close positive relationship between serum furin and IL-6, furin and presepsin, and furin and disease severity ( r = 0.793, p < 0001; r = 0.521, p < 0.001; and r = 0,533, p < 0.001, respectively) in patients with SARS-CoV-2. These results suggest that furin may contribute to the exacerbation of SARS-CoV-2 infection and increased inflammation, and could be used as a predictor of disease severity in COVID-19 patients.

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Section: Discussioncontrasting

confidence: 99%

“… 35 However, contrary to our findings, no correlation was found between furin and IL-6 levels in patients with rheumatoid arthritis. 35 Although inflammation occurs in both diseases, etiological reasons are different. Therefore, the reasons that trigger inflammation may be different.…”

Section: Discussioncontrasting

confidence: 99%

Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2–infected patients

Koçyiğit

Söğüt²,

Durmuş

et al. 2021

Science Progress

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“…Many studies have reported that the dysregulation of some functional genes was involved in the progression of RA [ 7 , 8 ]. For instance, the level of FURIN in peripheral blood from patients with RA was remarkably increased and was related to disorder activity [ 9 ]. FURIN inhibits THP-1-induced macrophages with increased IL-1 β levels, suggesting that FURIN could have anti-inflammatory functions [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

“…For instance, the level of FURIN in peripheral blood from patients with RA was remarkably increased and was related to disorder activity [ 9 ]. FURIN inhibits THP-1-induced macrophages with increased IL-1 β levels, suggesting that FURIN could have anti-inflammatory functions [ 9 ]. Information biology is a novel crossdiscipline subject integrating molecular biology as well as information technology [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

CKS2 and S100A12: Two Novel Diagnostic Biomarkers for Rheumatoid Arthritis

et al. 2022

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Rheumatoid arthritis (RA) is a chronic systematicness autoimmunity disease with joint inflammation. RA etiology is still unknown. Early and exact diagnosing is still hard to reach. In the paper, we purposed to discover novel diagnosis biological marker for RA. Two open, usable gene expression profiles of human RA as well as controlled specimens (dataset GSE17755 as well as GSE93272) were downloaded from the GEO database. Differentially expressed genes (DEGs) were screened between 331 RA and 88 control samples. Functional enrichment analysis was applied to explore the possible function of DEGs. Expression levels as well as diagnosis values of biological marker in RA were further verified in our cohort by the use of RT-PCR and ROC assays. We identified 13 DEGs between RA samples and control samples. 13 DEGs were remarkably abundant in NF-kappa B signal pathway. Among the 13 DEGs, CKS2, S100A12, LY96, and ANXA3 exhibited a strong diagnostic ability in screening RA specimens from normal specimens using all AUC > 0.8 . Moreover, we confirmed that the expression of CKS2 and S100A12 was distinctly upregulated in RA specimens contrasted to normal specimens. Overall, serum CKS2 and S100A12 could be used as novel diagnosis biological markers for RA patients.

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“…CD26 mRNA expression was found to be 1.68 times higher in RA patients compared with controls ( p = 0.001), and there was a strong positive association between DAS28 ( p = 0.002) and bone erosion in the hands ( p = 0.049) ( 77 ). In a study including 104 RA patients, FURIN mRNA expression was significantly increased in the peripheral blood of RA patients ( p < 0.001), and this was positively correlated with TGF-β1, RF, and anti-CCP ( 78 ). Another study comprising 187 patients with RA showed that serum IL-10 mRNA expression was 3.63-fold higher than in controls.…”

Section: Candidate Rnas As Biomarkers For Ramentioning

confidence: 99%

Biomarkers (mRNAs and non-coding RNAs) for the diagnosis and prognosis of rheumatoid arthritis

Jiang

Zhong

et al. 2023

Front. Immunol.

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In recent years, diagnostic and therapeutic approaches for rheumatoid arthritis (RA) have continued to improve. However, in the advanced stages of the disease, patients are unable to achieve long-term clinical remission and often suffer from systemic multi-organ damage and severe complications. Patients with RA usually have no overt clinical manifestations in the early stages, and by the time a definitive diagnosis is made, the disease is already at an advanced stage. RA is diagnosed clinically and with laboratory tests, including the blood markers C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) and the autoantibodies rheumatoid factor (RF) and anticitrullinated protein antibodies (ACPA). However, the presence of RF and ACPA autoantibodies is associated with aggravated disease, joint damage, and increased mortality, and these autoantibodies have low specificity and sensitivity. The etiology of RA is unknown, with the pathogenesis involving multiple factors and clinical heterogeneity. The early diagnosis, subtype classification, and prognosis of RA remain challenging, and studies to develop minimally invasive or non-invasive biomarkers in the form of biofluid biopsies are becoming more common. Non-coding RNA (ncRNA) molecules are composed of long non-coding RNAs, small nucleolar RNAs, microRNAs, and circular RNAs, which play an essential role in disease onset and progression and can be used in the early diagnosis and prognosis of RA. In this review of the diagnostic and prognostic approaches to RA disease, we provide an overview of the current knowledge on the subject, focusing on recent advances in mRNA–ncRNA as diagnostic and prognostic biomarkers from the biofluid to the tissue level.

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Increased FURIN expression in rheumatoid arthritis patients and its anti‐inflammatory effect

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 14 publications

References 25 publications

Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2–infected patients

Circulating furin, IL-6, and presepsin levels and disease severity in SARS-CoV-2–infected patients

CKS2 and S100A12: Two Novel Diagnostic Biomarkers for Rheumatoid Arthritis

Biomarkers (mRNAs and non-coding RNAs) for the diagnosis and prognosis of rheumatoid arthritis

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