Increased IgE but Reduced Th2-Type Inflammation in Vitamin D Receptor-Deficient Mice

D’Ambrosio, Daniele

doi:10.4049/jimmunol.174.8.4451

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…In fact, the extremely high levels of IgE antibodies circulating in VDR-KO mice might saturate MC FcεRI receptors, thereby preventing binding of OVA-specific IgE antibodies and MC activation, and in contrast to the suggestion made by Wittke et al [50], the high levels of IgE actually indicate a suppressive effect of 1,25(OH) 2 D 3 on the Th2 response. Therefore, those data might not really demonstrate a role for VDR in the generation of Th2-driven inflammation [51,52]. In support of a suppressive effect of 1,25(OH) 2 D 3 on Th2 responses, Topilski et al [53] have shown that 1,25(OH) 2 D 3 has antiinflammatory effects in a Th2-dependent asthma model in vivo, and we have recently described that BXL-628, a synthetic analog of 1,25(OH) 2 D 3 , inhibits bladder inflammation in a Th2-dependent, allergic model of interstitial cystitis [54].…”

Section: Discussionmentioning

confidence: 91%

VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3

Baroni

Biffi

Benigni

et al. 2006

Journal of Leukocyte Biology

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1,25-Dihydroxyvitamin D3 [1,25(OH)2D3] is a secosteroid hormone that regulates bone metabolism, controls calcium homeostasis, and possesses immunomodulatory properties. We show here that 1,25(OH)2D3 contributes to the regulation of development and function of mast cells, which play a critical role in several inflammatory disorders. 1,25(OH)2D3 promotes apoptosis and inhibits maturation of mouse bone marrow-derived mast cell precursors. Dose-dependent inhibition of mast cell differentiation by 1,25(OH)2D3 is observed at discrete, intermediate stages of mast cell development, identified by expression of c-kit, FcepsilonRI, and IL-3 receptor-alpha chain, and depends on the expression of the vitamin D receptor (VDR). It is important that mast cell progenitors obtained from VDR-ablated mice undergo an accelerated maturation in vitro and give rise to more responsive mast cells than wild-type. Furthermore, histological analysis of mast cell density in peripheral tissues reveals a moderate increase in the number of mast cells in the skin of VDR-deficient mice compared with wild-type animals. These data support the hypothesis of a physiological role of 1,25(OH)2D3 in mast cell development and suggest novel, therapeutic uses of 1,25(OH)2D3 analogs.

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Section: Discussionmentioning

confidence: 91%

VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3

Baroni

Biffi

Benigni

et al. 2006

Journal of Leukocyte Biology

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“…In vitro studies and mouse models suggest that vitamins may skew T cells towards either a less allergic T-helper 1 (vitamins B 6 , E, and C) or a more allergic T-helper 2 (vitamins D and A) phenotypes. 13, 14, 16, 17, 33–37 There may be a critical developmental window for such an effect. 3 If this is the case, premature infants could be more or less vulnerable than term infants.…”

Section: Discussionmentioning

confidence: 99%

Race differences in the association between multivitamin exposure and wheezing in preterm infants

et al. 2014

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Objective We aimed to determine whether vitamin D exposure, as estimated by use of multivitamins, is positively or negatively associated with recurrent wheezing in infants born preterm. Study Design This prospective cohort study enrolled 300 infants, born at 28 0/7– 34 6/7 weeks gestational age, and conducted follow-up at 3, 6, 9, and 12 months adjusted age. Results 55.9% of black and 36.6% of non-black infants experienced recurrent wheezing. Adjusted odds ratios for the association between multivitamin exposure at 3 months and recurrent wheezing were 2.15 (95% CI: 0.97, 4.75) for black and 0.43 (95% CI: 0.19, 0.96) for non-black infants with an interaction by race (p=0.003). In lag-effect models, odds ratios were 2.69 (95% CI: 1.41, 5.14) for black and 0.50 (95% CI: 0.27, 0.92) for non-black infants. Conclusions Differences by race were seen in associations between multivitamins and wheezing; population heterogeneity should be considered when evaluating vitamin supplementation.

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The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D3 in Patients with Allergic Rhinitis

Keleş

Ozkara

İlhan

et al. 2016

Turk Arch Otorhinolaryngol

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Objective: With regard to the correlation between T helper1/T helper2 (Th1/Th2) cell balance and 1α,25-dihydroxyvitamin D 3 , active metabolite of vitamin D, we studied Th1/Th2 cell balance by measuring levels of the cytokines interleukin (IL)-4, IL-10 and interferon-gamma (IFN-γ), which are important for immune response of patients with allergic rhinitis. Methods:Thirty adult patients diagnosed with allergic rhinitis (study group) and 40 healthy volunteers (control group) are examined in the research. IFN-γ, IL-4, IL-10, and total immunoglobulin E (IgE) levels from serum samples and vitamin D 3 levels from plasma were determined in all patients. Results:In IgE, IL-4, IL-10, IFN-γ, and 1α,25-dihydroxyvitamin D 3 levels (p<0.05), a statistically noticeable difference was observed between the study and control group. The 1α,25-dihydroxyvitamin D 3 levels in both groups were compared and a statistically significant difference between the 1α,25-dihydroxyvitamin D 3 levels in the study group and that in the control group (p<0.05) was observed. There was a positive correlation between IFN-γ and vitamin D levels (p<0.05) in the study group, whereas IgE, IL-4, and IL-10 levels showed a negative correlation with vitamin D 3 levels (p<0.05). Conclusion:In our study, 1α,25-dihydroxyvitamin D 3 levels were associated with Th1/Th2 balance in allergic rhinitis, and a remarkable correlation was observed among vitamin D deficiency and allergy. These findings show that 1α,25-dihydroxyvitamin D 3 may have a remarkable role in the severity and control of allergic disorders. In addition, further investigations are required to confirm how vitamin D should be used in allergic diseases. Furthermore, to reveal the exact mechanism of vitamin D on allergic diseases, further studies are required. Rhinitis, allergic, cholecalciferol, Th1 cells, Th2 cells, Keywords:

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Increased IgE but Reduced Th2-Type Inflammation in Vitamin D Receptor-Deficient Mice

Cited by 3 publications

References 11 publications

VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3

VDR-dependent regulation of mast cell maturation mediated by 1,25-dihydroxyvitamin D3

Race differences in the association between multivitamin exposure and wheezing in preterm infants

The Relationship between Th1/Th2 Balance and 1α, 25-Dihydroxyvitamin D3 in Patients with Allergic Rhinitis

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