Increased Igf‐I/Igfbp‐3 Ratios in Postmenopausal Taiwanese with Breast Cancer, Irrespective of Er and Pr Statuses and Her2 Expression in a Case–Control Study

Lee, Su-Chen; Hou, Ming‐Feng; Tien, Li-Ying; Wu, Szu-Hsien; Hou, Lisa; Tsai, Joseph M; Tsai, Li-Yu

doi:10.1002/jcla.21815

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…The positive associations between the IGF‐1 and the risks of breast cancer, papillary thyroid cancer, and prostate cancer were found in the previous studies, 10 , 11 , 12 , 13 but the risk of gastric cancer decreased in the individuals with IGF‐1 gene rs2195239 polymorphism. 14 Nevertheless, no significant difference of IGF‐1 levels between the breast cancer patients and the controls was found in our previous study 15 and another studies. 16 , 17 In addition to the influences of menopausal statuses, 10 racial variations, 18 gene polymorphism, 14 and subtypes of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 (HER2), 19 the associations between the IGF‐1 levels and biomarkers of skeletal muscles, liver function and bone modulation were worthy to investigate.…”

Section: Introductionmentioning

confidence: 65%

Insulin‐like growth factor‐1 positively associated with bone formation markers and creatine kinase in adults with general physical activity

Lee

Hsiao

Yang

et al. 2021

Clinical Laboratory Analysis

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Background The Insulin‐like growth factor‐1 (IGF‐1) is primarily synthesized by hepatocytes in a growth hormone (GH)‐dependent manner, it is also produced by bone and muscle. The effects of exercise on the associations between IGF‐1 levels and bone turnover markers (BTM) were found in the previous studies. However, the associations between the levels of IGF‐1 and BTM, liver function tests, and skeletal muscle markers in adults with general physical activity were not clear. Methods Ninety‐four participants were recruited from healthy survey. Blood samples were collected to analyze the levels of IGF‐1, total protein (TP), albumin (Alb), total bilirubin (T‐Bil), direct bilirubin (D‐Bil), aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), bone alkaline phosphatase (BALP), lactate dehydrogenase (LDH), creatine kinase (CK), creatinine (CRTN), and glucose. Urine samples were collected to analyze the CRTN and deoxypyridinoline (Dpd) levels. Results The positively significant associations were found between the IGF‐1 levels and the levels of ALP, BALP, and CK, respectively. No significant associations were found between the IGF‐1 levels and the levels of TP, Alb, A/G, T‐Bil, D‐Bil, AST, ALT, LDH, glucose, urinary CRTN, urinary Dpd, and Dpd/CRTN ratios, respectively. Conclusion The serum IGF‐1 levels associated with the levels of skeletal muscle and bone formation markers (BFM), not the bone resorption markers under general physical activity in the healthy adults. The physician needs to consider the effects of bone formation and skeletal muscle markers on the IGF‐1 levels in the management of IGF‐1‐related disorders.

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Section: Introductionmentioning

confidence: 65%

Insulin‐like growth factor‐1 positively associated with bone formation markers and creatine kinase in adults with general physical activity

Lee

Hsiao

Yang

et al. 2021

Clinical Laboratory Analysis

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“…The change in IGF-1/IGFBP-3 ratio was statistically significant but modest (mean absolute change, 1.5 × 10 −3 ; percentage change, 4.3%). Whether this change is clinically relevant remains to be seen, however, comparable differences were seen between breast cancer cases and age-matched unaffected controls [ 36 ]. Since we did not adjust for multiple comparisons for the secondary biomarker endpoints, these results need to be interpreted with caution and confirmed in larger studies.…”

Section: Discussionmentioning

confidence: 99%

Safety, Feasibility, and Biomarker Effects of High-Dose Vitamin D Supplementation Among Women at High Risk for Breast Cancer

Crew

Xiao

Thomas

et al. 2015

IJFS

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Vitamin D deficiency is a potentially modifiable risk factor that may be targeted for breast cancer prevention. We examined the safety, feasibility, and biomarker effects of high-dose vitamin D among women at high risk for breast cancer. Forty high-risk women, defined as a 5-year breast cancer risk ≥1.67% per the Gail model, lobular or ductal carcinoma in situ, were assigned to a 1-year intervention of vitamin D3 20,000 IU or 30,000 IU weekly. Participants were monitored for toxicity every 3 months, underwent serial blood draws at baseline, 6 and 12 months, and a digital mammogram at baseline and 12 months. Biomarker endpoints included serum 25-hydroxyvitamin D [25(OH)D], 1,25-dihydroxyvitamin D [1,25(OH)2D], parathyroid hormone (PTH), insulin-like growth factor (IGF-1), IGF binding protein (IGFBP-3), and mammographic density (MD) using Cumulus software. From November 2007 to January 2011, we enrolled 40 women; 37 were evaluable at 6 months and 30 at 12 months. One patient was taken off study for hypercalciuria; otherwise, the intervention was well tolerated. From baseline to 12 months, mean serum 25(OH)D and 1,25(OH)2D rose from 20.0 to 46.9 ng/ml and 69.7 to 98.1 pg/ml, respectively (p<0.01). Serum PTH decreased by 12% at 6 months and IGF-1/IGFBP-3 ratio decreased by 4.3% at 12 months (p<0.05). There was no significant change in MD regardless of menopausal status or dose level. We demonstrated that 1 year of high-dose vitamin D3 was associated with a significant increase in circulating vitamin D levels and favorable effects on IGF signaling, but no significant change in MD.

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The effects of physical activity on physiological markers in breast cancer survivors

Kang

et al. 2020

Medicine

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Background: To systematically evaluate the effects of physical activity on physiological markers in breast cancer survivors. Methods: A systematic search of the PubMed, Wed of Science, Medline, CNKI and Wanfang Database was performed to identify eligible randomized controlled trials to explore physical activity on physiological markers in breast cancer survivors. STATA version 13.0 (Stata Corp LP, College Station, TX) was used for all statistical analyses. Results: A total of 11 articles with 941 cases were eligible in this meta-analysis. The results of the meta-analysis showed that physical activity could decrease the levels of insulin (SMD = −1.90, 95%CI: −3.2 to −0.60; I2 = 92.3%, P < .001), insulin-like growth factor 1 (IGF-I) (WMD = −4.67, 95%CI: −23.14 to 13.79; I2 = 96.2%, P < .001), insulin-like growth factor binding protein-3 (IGFBP-3) (WMD = −20.09, 95%CI: −47.15 to 6.97; I2 = 93.3%, P < .001). However, compared with the control group, there was not the significant change of insulin-like growth factor 2 (IGF-II), insulin-like growth factor binding protein-1 (IGFBP-1), leptin, adiponectin, glucose, C-reactive protein (CRP), Interleukin-6 (IL-6), Interleukin-10 (IL-10), and tumor necrosis factor alpha (TNF-ɑ) levels after the intervention. Conclusions: Physical activity could improve the insulin function that might be associated with decreasing the levels of IGF-I, IGFBP-3 and insulin in breast cancer survivors.

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Increased Igf‐I/Igfbp‐3 Ratios in Postmenopausal Taiwanese with Breast Cancer, Irrespective of Er and Pr Statuses and Her2 Expression in a Case–Control Study

Abstract: The ratios of IGF-I/IGFBP-3 were increased in postmenopausal Taiwanese women with BC, irrespective of their ages, ER and PR statuses, and HER2 expression.

Cited by 4 publications

References 36 publications

Insulin‐like growth factor‐1 positively associated with bone formation markers and creatine kinase in adults with general physical activity

Insulin‐like growth factor‐1 positively associated with bone formation markers and creatine kinase in adults with general physical activity

Safety, Feasibility, and Biomarker Effects of High-Dose Vitamin D Supplementation Among Women at High Risk for Breast Cancer

The effects of physical activity on physiological markers in breast cancer survivors

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