1994
DOI: 10.1016/s0168-8278(05)80488-x
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Increased IgM B cell differentiation lymphokine production by T lymphocytes from patients with primary biliary cirrhosis

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Cited by 11 publications
(7 citation statements)
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“…yIFN also enhances the cytotoxic activity of NK cells [ 3 11. Furthermore, aTNF and IL-6 regulate T lymphocyte activation [32-341. The alterations found in T lymphocyte and NK cell compartments of ATP patients can be associated with abnormal patterns of lymphokine production, as has been described for other autoimmune diseases [35,36].…”
Section: Introductionmentioning
confidence: 57%
See 1 more Smart Citation
“…yIFN also enhances the cytotoxic activity of NK cells [ 3 11. Furthermore, aTNF and IL-6 regulate T lymphocyte activation [32-341. The alterations found in T lymphocyte and NK cell compartments of ATP patients can be associated with abnormal patterns of lymphokine production, as has been described for other autoimmune diseases [35,36].…”
Section: Introductionmentioning
confidence: 57%
“…There is evidence that different patterns of lymphokine secretion can be found in different subsets of this lymphocyte compartment, which have been termed TH1, TH2, and THO [42]. Alterations in the patterns of T lymphocyte lymphokine secretion have been associated with several functional impairments in autoimmune and infectious diseases [35,36,43,44]. These lymphokine abnormalities may express alterations in the homeostatic interactions between T lymphocytes and/or structural modifications in these cells.…”
Section: Dlscussionmentioning
confidence: 99%
“…Similarly, alterations in natural killer activity [5] and lectin-induced proliferation of T lymphocytes have both been described [6]. However, an increase of serum immunoglobulin concentration is present in patients with liver cirrhosis, and this is possibly indicative of an altered balance between T lymphocyte helper responses implicated in cytotoxicity [T helper type 1 (Th1)] and those implicated in the synthesis of specific antibodies (Th2) [7,8].…”
Section: Introductionmentioning
confidence: 99%
“…In addition, several studies have suggested a pivotal role for T–B‐cell cooperation in the regulation of Ig synthesis in chronic liver disease. For example, T cells from PBC patients have an enhanced ability to promote the differentiation of B cells into Ig‐secreting cells, which is in part related to production of IL6 (9, 10). The present study explores another mechanism by which T cells are known to promote B‐cell differentiation and secretion of Ig: the engagement of B‐cell CD40 by its ligand, CD154 (CD40L).…”
mentioning
confidence: 99%