Increased integrity of cell–cell junctions accompanied by increased expression of claudin 4 in keratinocytes stimulated with vitamin D3

Minowa, Erika; Kurashige, Yoshihito; Islam, Syed Taufiqul; Yoshida, Koki; Sakakibara, Sayaka; Okada, Yunosuke; Fujita, Yusuke; Bolortsetseg, Dembereldorj; Murai, Yuji; Saitoh, Masato

doi:10.1007/s00795-021-00299-1

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…Regulation of expression and function of TJs largely depends on their composition, namely, the presence and assembly of several TJ proteins. Experimental and treatmentoriented modulation of the epidermal TJ system can therefore be exploited [52][53][54][55][56][57][58][59][60]. Alteration of expression of TJ components modifies permeability, even though the junction structures may persist morphologically [12].…”

Section: Discussionmentioning

confidence: 99%

The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions

Haftek

Oji

Feldmeyer³

et al. 2022

IJMS

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We evaluated the presence of tight junction (TJ) remnants in the stratum corneum (SC) of in vitro reconstructed human epidermis and human skin explants subjected or not to an aggressive topical treatment with beta-lipohydroxy salicylic acid (LSA) for 24 h. LSA-treated samples showed an increased presence of TJ remnants in the two lowermost layers of the SC, as quantified with standard electron microscopy. The topical aggression-induced overexpression of TJ-like cell–cell envelope fusions may influence SC functions: (1) directly, through an enhanced cohesion, and (2) indirectly, by impeding accessibility of peripheral corneodesmosomes to extracellular hydrolytic enzymes and, thus, slowing down desquamation. Observations of ichthyotic epidermis in peeling skin disease (PSD; corneodesmosin deficiency; two cases) and ichthyosis hypotrichosis sclerosing cholangitis syndrome (IHSC/NISCH; absence of claudin-1; two cases) also demonstrated increased persistence of TJ-like intercellular fusions in pathological SC and contributed to the interpretation of the diseases’ pathological mechanisms.

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