Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy

Skopiński, Piotr; Rogala, E; Duda-Król, Barbara; Lipińska, Anna; Sommer, Ewa; Chorostowska‐Wynimko, Joanna; Szaflik, Jerzy; Partyka, Iwona; Skopińska-Różewska, Ewa

doi:10.1016/j.jdiacomp.2005.02.008

Cited by 34 publications

(24 citation statements)

References 15 publications

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“…It is claimed that endothelial cell activation and damage play a potentially crucial role in the pathogenesis of microvascular complications in diabetes [1,10]. Hence, the early diagnosis of vascular pathology is vital for the therapy of diabetic patients.…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, according to recent studies, chronic inflammation leads to the impairment of endothelial function and microvascular complications in the course of diabetes [3,10]. Our previous report showed a relation between the severity of capillaroscopic changes and metabolic control and the presence of persistent complications in patients with type 1 diabetes [18].…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that increased pressure in the capillary vascular bed [17], nonenzymatic glycation of basal membrane proteins [20], endothelial dysfunction and angiogenic activity [1,10] are implicated in the pathogenesis of microcirculation disturbances in diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…In pathological conditions, IL-18 is involved in angiogenesis [10], arteriosclerosis [11], tissue destruction, and seems to play a role in the autoimmune b-cell destruction [12]. Recent studies have shown that circulating IL-18 may be a predictor of progression of diabetic nephropathy as well as cardiovascular diseases [13].…”

Section: Introductionmentioning

confidence: 99%

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Microvascular abnormalities in capillaroscopy correlate with higher serum IL-18 and sE-selectin levels in patients with type 1 diabetes complicated by microangiopathy

Kuryliszyn-Moskal¹,

Dubicki²,

Zarzycki³

et al. 2011

Folia Histochem Cytobiol.

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Microvascular abnormalities are one of the most important causes of persistent diabetic complications. The aim of this study was to compare microvascular changes examined by nailfold capillaroscopy with serum concentrations of soluble E-selectin (sE-selectin) and IL-18 in type 1 diabetic patients with and without microangiopathy. Serum levels of sE-selectin and IL-18 were determined by an enzyme-linked immunosorbent assay in 106 patients with type 1 diabetes and in 40 healthy controls. All diabetic patients were evaluated by extensive clinical, laboratory and capillaroscopic studies. Morphological changes were observed by nailfold capillaroscopy in 86 out of 106 (81%) diabetic patients. Severe capillaroscopic changes were seen in 32 out of 54 (59%) patients with microangiopathy, but in only seven out of 52 (13%) patients without microangiopathy. Higher serum levels of sE-selectin (p < 0.001) and IL-18 (p < 0.05) were demonstrated in diabetic patients compared to controls. Significant differences of sE-selectin (p < 0.001) and IL-18 (p < 0.01) serum concentrations were observed between diabetic patients with microangiopathy and controls. Moreover, comparison between patients with and without microangiopathic complications showed a significantly higher capillaroscopic score and sE-selectin serum concentration in the group with microangiopathy (p < 0.001). Furthermore, diabetic patients with severe microvascular changes in capillaroscopy showed significantly higher IL-18 (p < 0.001) and sE-selectin (p < 0.05) serum levels than subgroups without changes or with mild abnormalities. Our findings suggest that abnormalities in nailfold capillaroscopy may reflect the extent of microvascular involvement and are associated with higher sE-selectin and IL-18 serum levels, as well as with microangiopathic complications in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Microvascular abnormalities in capillaroscopy correlate with higher serum IL-18 and sE-selectin levels in patients with type 1 diabetes complicated by microangiopathy

Kuryliszyn-Moskal¹,

Dubicki²,

Zarzycki³

et al. 2011

Folia Histochem Cytobiol.

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“…The inverse relationship with TNF-α is consistent with studies which demonstrate that TNF-α can inhibit IGF-1 production of in vitro hepatocytes, even in the presence of GH stimulation (Wolf et al, 1996;Thissen and Vernier, 1997). Although limited research exists that examines the association between IL-18 and the IGF system, previous findings do indicate that IL-18 is negatively associated with IGF-1 and growth (Skopiński et al, 2005;Netea et al, 2006). Future research should explore the mechanisms by which TNF-α and IL-18 may interact with hepatic expression of IGF-1.…”

Section: Discussionmentioning

confidence: 97%

Immunomodulatory factors and infectious agents associated with the hepatic gene expression of the IGF system in nursery pigs

Slifierz

Friendship

Lange

et al. 2014

Animal

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Recent findings suggest there is a complex interaction between the IGF system and the inflammatory immune response. The objective of this study was to determine whether gene expression of growth factors (IGF-1, IGF-binding protein-3 (IGFBP-3) and growth hormone receptors (GHR)) in the liver is associated with gene expression of immunomodulators in the liver, including C-reactive protein (CRP), serum amyloid A (SAA), haptoglobin (Hp), interferon-α (IFN-α), IFN-γ, tumour necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, IL-10 and IL-18, as well as with the presence of Salmonella spp., Lawsonia intracellularis, Brachyspira spp., enterotoxigenic Escherichia coli, methicillin-resistant Staphylococcus aureus, swine influenza virus, and porcine reproductive and respiratory syndrome virus (PRRSV) in nursery pigs (n = 74) from commercial farms (n = 4). Gene expression was quantified using reverse transcription quantitative-PCR (RT-qPCR) and the data were modelled using logistic regression methods. Pigs with elevated IGF-1 expression were less likely to have increased expression of TNF-α (odds ratio (OR) = 0.14, P < 0.01) and IL-18 (OR = 0.19, P < 0.05), and less likely to be colonized with PRRSV (OR = 0.03, P < 0.01). Pigs with increased expression of IGFBP-3 were more likely to have elevated IL-6 expression (OR = 8.5, P < 0.05). It was also observed that IGFBP-3 and IGF-1 were significantly associated when Hp expression was low (OR = 30, P < 0.05), but this association was not significant when Hp expression was high ( P = 0.54). Pigs with increased expression of GHR were less likely to have elevated expression of SAA (OR = 0.01, P < 0.05) and IL-1β (OR = 0.03, P < 0.05), but more likely to have increased expression of CRP (OR = 290, P < 0.01). Overall, there appears to be an inverse association between the hepatic expression of the IGF system (IGF-1, IGFBP-3, GHR) and certain cytokines (IL-1β, IL-18, TNF-α) and acute-phase proteins (SAA, Hp).

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Gut microbiota intervention strategies using active components from medicinal herbs to evaluate clinical efficacy of type 2 diabetes – A review

Patel

Moochhala

2023

Clinical and Translational Dis

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Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy

Cited by 34 publications

References 15 publications

Microvascular abnormalities in capillaroscopy correlate with higher serum IL-18 and sE-selectin levels in patients with type 1 diabetes complicated by microangiopathy

Microvascular abnormalities in capillaroscopy correlate with higher serum IL-18 and sE-selectin levels in patients with type 1 diabetes complicated by microangiopathy

Immunomodulatory factors and infectious agents associated with the hepatic gene expression of the IGF system in nursery pigs

Gut microbiota intervention strategies using active components from medicinal herbs to evaluate clinical efficacy of type 2 diabetes – A review

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