Increased interleukin‐6 production during the acute phase of the syndrome of episodic angioedema and hypereosinophilia

(Isabelle), Tillie-Leblond; Gosset,; Janin,; Salez,; Prin,; Tonnel,

doi:10.1046/j.1365-2222.1998.00268.x

Cited by 37 publications

(6 citation statements)

References 24 publications

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“…IL-6 is produced by a wide variety of cell types and is known to contribute to Th2 cytokine production, lung eosinophilia, and airway hyperresponsiveness [ 32 ]. As such, it was found to be higher in serum of asthmatic patients [ 33 , 34 ] and mice [ 32 ]. In our study, as expected, IL-6 was significantly higher in lung homogenates from ova-ova WT group compared to the sal-ova controls.…”

Section: Resultsmentioning

confidence: 99%

March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Kishta

Sabourin

Simon

et al. 2018

Journal of Immunology Research

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Membrane-associated RING-CH-1 (March1) is a member of the March family of E3 ubiquitin ligases. March1 downregulates cell surface expression of MHC II and CD86 by targeting them to lysosomal degradation. Given the key roles of MHC class II and CD86 in T cell activation and to get further insights into the development of allergic inflammation, we asked whether March1 deficiency exacerbates or attenuates features of allergic asthma in mice. Herein, we used an acute model of allergy to compare the asthmatic phenotype of March1-deficient and -sufficient mice immunized with ovalbumin (OVA) and later challenged by intranasal instillation of OVA in the lungs. We found that eosinophilic inflammation in airways and lung tissue was similar between WT and March1−/− allergic mice, whereas neutrophilic inflammation was significant only in March1−/− mice. Airway hyperresponsiveness as well as levels of IFN-γ, IL-13, IL-6, and IL-10 was lower in the lungs of asthmatic March1−/− mice compared to WT, whereas lung levels of TNF-α, IL-4, and IL-5 were not significantly different. Interestingly, in the serum, levels of total and ova-specific IgE were reduced in March1-deficient mice as compared to WT mice. Taken together, our results demonstrate a role of March1 E3 ubiquitin ligase in modulating allergic responses.

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Section: Resultsmentioning

confidence: 99%

March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

Kishta

Sabourin

Simon

et al. 2018

Journal of Immunology Research

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“…The angioedema of EAE and NEAE is likely associated with a temporal increase in the vascular permeability of local capillaries via some mediators, including antiendothelial cell antibodies and cytokines3, 14-16). Several reports have shown that histamine levels are within normal limits, and that IL-1, IL-5, and IL-6 generated by monocytes, endothelial cells, T cells, and eosinophils increase during the acute phase of EAE3, 5, 11, 15, 16). According to a recent report, IL-5 levels were determined to be lower, and TNF-αlevels were higher in the acute phase of NEAE than in the acute phase of EAE.…”

Section: Discussionmentioning

confidence: 99%

“…Many other cases have been detected since this initial report, and this syndrome has been recognized as a distinct clinical entity2, 3). More than 40 cases with symptomatic presentations and laboratory findings similar to EAE have been reported, but these cases have not involved recurrent attacks, and thus have been subsequently designated as nonepisodic angioedema with eosinophilia (NEAE)4-8).…”

Section: Introductionmentioning

confidence: 99%

A case report of nonepisodic angioedema with eosinophilia in a Korean patient and a review of the Korean literature

Jang

Kim²,

Kim³

et al. 2006

Korean J Intern Med

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Episodic angioedema with eosinophilia (EAE) is characterized by recurrent angioedema, peripheral eosinophilia, elevated serum IgM, fever, weight gain, and a benign course lacking any internal organ involvement. Dozens of cases of the nonepisodic variant (NEAE), which is limited to a single attack, have been reported in Japan. These NEAE cases normally have been less severe than the episodic type. In this paper, we describe the case of a Korean patient whose clinical and laboratory findings were consistent with NEAE, and review five other cases of EAE and NEAE reported in the Korean literature. The Korean NEAE cases outlined in this paper demonstrate that, as in Japan, NEAE is not uncommon in Korea, and also suggest that this disease exhibits a cultural predilection for Asian populations.

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“…Eosinophil activation is also associated with acute symptoms such as flare‐ups (Tillie‐Leblond et al , 1998; Vandezande et al , 1999; Daneshpouy et al , 2002a) or early recurrences (Desreumaux et al , 1992; Dubucquoi et al , 1995) of inflammatory diseases, microvascular lesions, and necrosis (Leiferman, 1991; Launay et al , 2000). Release of cationic proteins (ECP and MBP) can also lead to lipid membrane disruption and target cell death (Weller, 1994).…”

Section: Clinical and Pathological Features Of Oral Lesions In Hesmentioning

confidence: 99%

Oral mucosa lesions in hypereosinophilic syndrome – an update

2008

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Hypereosinophilic syndrome (HES) is a rare disorder characterized by persistent and marked eosinophilia. Some HES forms have a poor prognosis, either because of end-organ damage (particularly endomyocardial fibrosis), or because of associated myeloid leukemia or malignant T-cell lymphoma. Oral mucosa ulcerations can be early clinical signs in severe forms. They are discrete, round or oval, sometimes confluent ulcers or erosions, located on non-keratinized, unattached oral mucosa. In the last 15 years a better understanding of eosinophil biology has led to a new clinical classification of HES. The lymphocytic form is characterized by T-lymphocyte clonality, IL-5 production, and a possible progression to T-cell lymphoma. Oral lesions are more frequently associated with the myeloproliferative form, characterized by an increased risk of developing myeloid malignancies and a good response to a recent anti-tyrosine kinase therapy (imatinib mesylate). The target of imatinib is a novel kinase resulting from an 800-kb deletion on chromosome 4. Recently, the resulting FIP1L1-PDGFRalpha fusion gene was characterized as a marker of response to imatinib. Exclusion of other erosive ulcerative oral disease and early recognition of HES in patients with oral ulcerations, and precise characterization of the lymphocytic or myeloproliferative form are therefore important to rapidly initiate an effective therapy.

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Increased interleukin‐6 production during the acute phase of the syndrome of episodic angioedema and hypereosinophilia

Cited by 37 publications

References 24 publications

March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

March1 E3 Ubiquitin Ligase Modulates Features of Allergic Asthma in an Ovalbumin-Induced Mouse Model of Lung Inflammation

A case report of nonepisodic angioedema with eosinophilia in a Korean patient and a review of the Korean literature

Oral mucosa lesions in hypereosinophilic syndrome – an update

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