Increased interventricular septum wall thickness predicts all‐cause death in patients with coronary artery disease

Huang, Bao‐Tao; Peng, Yong; Liu, W.; Zhang, C.; Huang, Fang‐Yang; Wang, P.-J.; Zuo, Zhi‐Liang; Liao, Yanbiao; Chai, Hua; Huang, Kaisen; Huang, Dejia; Chen, M.

doi:10.1111/imj.12667

Cited by 13 publications

(12 citation statements)

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“…After further correction for age and gender, associations remain significant for insulin levels, HOMA-IR, and AHI. Previously, multiple studies established that increased IVST is associated with an adverse metabolic profile [40][41][42], higher blood pressure in young healthy adults [43,44], and higher all-cause mortality in adults with cardiovascular disease [45,46]. Our findings support the hypothesis that hyperinsulinemia plays a role in the nonhemodynamic pathogenesis of cardiac hypertrophy, albeit limited to the ventricular septum.…”

Section: Discussionsupporting

confidence: 86%

Left Ventricular Geometrical Changes in Severely Obese Adolescents: Prevalence, Determinants, and Clinical Implications

et al. 2020

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Left ventricular hypertrophy (LVH) is independently associated with a higher risk of cardiovascular morbidity and mortality in adults. Adiposity is a risk factor for LVH, independent of blood pressure. Potential causes of this nonhemodynamic pathogenesis identified in adults include adverse body fat distribution, insulin resistance, dyslipidemia, and obstructive sleep apnea syndrome (OSA). In severely obese adolescents, the determinants of obesity-induced changes in left ventricular structure are poorly characterized. Cardiac ultrasonographic, demographic, anthropometric, and comorbidity-related data were prospectively collected in adolescents with severe obesity refractory to conservative treatment who presented for surgical therapy. Differences between adolescents with LVH and without LVH were evaluated using independent samples t, chi-square, or Fisher’s exact test. Multivariable linear regression analysis was performed to evaluate associations with left ventricular structural changes, corrected for body mass index (BMI) z score. Forty-three patients entered analysis, of whom 24 (55.8%) showed LVH. The most common geometrical change was eccentric LVH (eLVH), occurring in 21 subjects (48.8%). Demographic and anthropometric variables did not differ between patients with and without LVH. Independent of BMI z score, left ventricular mass index was significantly associated with apnea–hypopnea index (AHI) (regression parameter B = 0.8; 95% CI 0.3 to 1.2). Interventricular septum thickness (IVST) was significantly associated with HOMA-IR values (B = 0.1; 95% CI 0.04 to 0.2), HDL-cholesterol (B = − 1.2; 95% CI − 2.2 to 0.1), and triglyceride levels (B = 0.5; 95% CI 0.001 to 0.9). LVH, especially eLVH, is highly prevalent amongst severely obese adolescents. Adverse changes in cardiac structure, increased IVST in particular, are independently associated with several nonhemodynamic comorbidities that are common in this population, namely OSA, insulin resistance, and dyslipidemia.

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Section: Discussionsupporting

confidence: 86%

Left Ventricular Geometrical Changes in Severely Obese Adolescents: Prevalence, Determinants, and Clinical Implications

et al. 2020

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“…In a study of hypertensive patients receiving regular treatment, multivariate adjusted analysis showed that greater IVST at baseline was associated with worse cardiovascular outcomes during 5 years of follow-up [28]. Huang et al [29] concluded that thickened IVS can be served as a reliable marker for predicting all-cause death in Chinese patients with coronary artery disease, even in those with normal LVM. Graham-Brown et al [30] compared global and segmental native myocardial T1 time of 35 hemodialysis patients and 22 control individuals and found that the median native global T1 time was significantly higher in the hemodialysis group (1,270 vs. 1,085 ms), with the septal regions of hemodialysis patients having significantly higher median T1 times than nonseptal regions (1,293 vs. 1,252 ms).…”

Section: Discussionmentioning

confidence: 99%

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Zhang

Guo

et al. 2019

Kidney Blood Press Res

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Background: Cardiovascular disease is the leading cause of morbidity and mortality in maintenance hemodialysis (MHD) patients. Uremic cardiomyopathy, characterized by myocardial hypertrophy and fibrosis, has a significant contribution to these adverse cardiac outcomes. The protective effect of soluble Klotho (s-Klotho) on myocardial damage was demonstrated in in vitro and animal experiments. However, data from MHD patients is limited. The present study was designed to identify potential correlations between echocardiographic parameters and serum s-Klotho levels in MHD patients. Methods: This is a cross-sectional study involving 105 MHD patients from the Dialysis Center of Capital Medical University affiliated Beijing Friendship Hospital between March and October 2014. The general information for each patient was recorded. Fasting blood samples were collected prior to hemodialysis during the mid-week session in all patients. The echocardiogram and left lateral lumbar spine radiograph were performed after the same mid-week session. The dialysis records for each session within 3 months before the blood tests were documented. According to the quartiles of s-Klotho levels, patients were divided into four groups (Group 1–4). The demographic and clinical characteristics, echocardiographic parameters, and abdominal aortic calcification scores among the groups were compared. Results: The enrolled 105 patients were predominantly male (54.3%) with an average age of 59.9 ± 11.2 years. Previous hemodialysis durations were 76 (42–133) months. Sixteen (15.2%) patients had diabetes mellitus. Mean serum s-Klotho level was 411.83 ± 152.95 pg/mL, and the 25th percentile, 50th percentile, and 75th percentile values of serum s-Klotho levels were 298.9, 412, and 498.2 pg/mL, respectively. Individuals in the bottom quartile of s-Klotho levels (Group 1) had significantly increased interventricular septal thickness (IVST) compared to those in the other three quartiles of s-Klotho levels (Group 1: 1.12 ± 0.16 cm; vs. Group 2: 1.12 ± 0.16 cm, p = 0.008; vs. Group 3: 0.94 ± 0.13 cm, p < 0.001; vs. Group 4: 1.03 ± 0.1 5 cm, p = 0.022). There were significant differences in the ratios of IVST and posterior wall thickness (PWT) between patients of Group 1 and Group 3 (1.12 ± 0.1 2 vs. 1.00 ± 0.1 4, p = 0.004). No significant differences were found for other parameters among the groups. The univariate correlation analyses showed that gender (r = –0.211, p = 0.030), Kt/V urea (r = –0.240, p = 0.014), hypersensitive C reactive protein (hs-CRP) (r = 0.196, p = 0.045), and serum s-Klotho levels (r = –0.260, p = 0.007) significantly correlated with IVST. Ultimately, only hs-CRP and serum s-Klotho levels were entered into a multiple regression model. Conclusions: The present study showed that patients with lower circulating s-Klotho levels were more often associated with larger IVST and greater ratios of IVST and PWT. There was an independent association between s-Klotho and IVST, and lower s-Klotho levels seem to be a potential risk factor of uremic...

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“…While IVS hypertrophy in adults predicts all cause death in coronary artery disease [40] , the predictive role of IVS hypertrophy for all deaths in children recipients of LROLT still awaits further research.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary hypertension and cardiac hypertrophy in children recipients of orthotopic living related liver transplantation

Kotb

Satar

Badr

et al. 2017

Journal of Advanced Research

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Increased interventricular septum wall thickness predicts all‐cause death in patients with coronary artery disease

Abstract: Thickened IVS can be served as a reliable marker for predicting all-cause death in Chinese patients with CAD, even in those with normal left ventricular mass.

Cited by 13 publications

References 20 publications

Left Ventricular Geometrical Changes in Severely Obese Adolescents: Prevalence, Determinants, and Clinical Implications

Left Ventricular Geometrical Changes in Severely Obese Adolescents: Prevalence, Determinants, and Clinical Implications

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Pulmonary hypertension and cardiac hypertrophy in children recipients of orthotopic living related liver transplantation

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