Increased Leptin and Leptin Receptor Expression in Dogs With Gallbladder Mucocele

Lee, S.; Kweon, Oh‐Kyeong; Kim, W.H.

doi:10.1111/jvim.14612

Cited by 20 publications

(30 citation statements)

References 39 publications

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“…The absence of a comparable condition in humans limits our understanding of the pathogenesis of GBMs in dogs. Recognized risk factors for GBM formation include hyperadrenocorticism, hypothyroidism, hyperlipidemia, neonicotinoids, and recently, increased serum leptin . These conditions could act by altering the composition of bile and mucin or through an effect on gall bladder motility .…”

Section: Introductionmentioning

confidence: 99%

Gall bladder mucoceles in Border terriers

Allerton

Swinbourne

Barker

et al. 2018

Veterinary Internal Medicne

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BackgroundGall bladder mucoceles (GBM) are a leading cause of biliary disease in dogs with several breeds, including the Shetland Sheepdog, American Cocker Spaniel, Chihuahua, Pomeranian, and Miniature Schnauzer apparently predisposed.ObjectiveTo determine risk factors, clinical features, and response to treatment of GBM in Border terriers (BT).AnimalsMedical records of 99 dogs (including 51 BT) with an ultrasonographic (±histopathologic) diagnosis of GBM from three referral centers in the United Kingdom were collected. A control group of 87 similar‐aged BT with no ultrasonographic evidence of gall bladder disease was selected for comparison.MethodRetrospective case‐control study. Odds ratios were calculated to establish breed predisposition. Signalment, presence of endocrine disease, clinicopathologic results, and outcome were compared between the BT, other breeds, and control BTs.ResultsThe odds of identifying a GBM in a BT in this hospital population was 85 times that of all other breeds (95% confidence interval 56.9‐126.8). BT had similar clinical signs and clinicopathologic changes to other breeds with GBM. There was no evidence that endocrinopathies were associated with GBM in BT.Clinical SignificanceA robust breed predisposition to GBM is established for the BT.

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Section: Introductionmentioning

confidence: 99%

Gall bladder mucoceles in Border terriers

Allerton

Swinbourne

Barker

et al. 2018

Veterinary Internal Medicne

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“…Although echoic patterns differ with the nature and type of gallbladder content, conventional ultrasonography generally identifies biliary sludge and/or sludge balls that move and/or change shape following changes in body position . Gallbladder mucoceles are frequently found in older dogs with endocrine disorders . They are likely due to hyperplasia of mucus glands and overproduction of mucus and/or fibrin that accumulates in the gallbladder, causing gallbladder distension with subsequent potential ischemia and/or necrosis of the wall .…”

Section: Introductionmentioning

confidence: 99%

Contrast‐enhanced ultrasound complements two‐dimensional ultrasonography in diagnosing gallbladder diseases in dogs

Bargellini¹,

Orlandi²,

Paloni³

et al. 2018

Vet Radiology Ultrasound

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Gall-bladder diseases are common in dogs and two-dimensional ultrasonography is a current standard method for diagnosis and treatment planning. However, findings from this modality can be nonspecific. The aim of this retrospective, case series study was to describe conventional and contrast-enhanced ultrasound (using SonoVue ) findings in a group of dogs with histologically confirmed gall bladder disease. A total of 65 dogs were included. Branchlike, heterogeneous, and homogeneous contrast enhancement of echogenic intraluminal mass-forming lesions was a contrast-enhanced ultrasound characteristic of polypoid lesions due to cystic mucosal hyperplasia of the gallbladder and/or tumor, which had different wash-in and washout characteristics. In dogs with mobile or immobile biliary sludge or mucocele, the echogenic intraluminal masses remained unenhanced. A double rim mark or enhancement defect in the gallbladder wall was a characteristic of edema or necrosis/rupture of the wall, respectively. Conventional ultrasonography correctly identified biliary sludge or mucocele in 36/37 dogs, cholecystitis/edema in 44/47 dogs, necrosis/rupture in 19/25 dogs, and gallbladder neoplasia in three of three dogs with these pathologies. It falsely identified biliary sludge or mucocele in eight of 28 dogs, cholecystitis/edema in three of 15 dogs, necrosis/rupture in 13/37 dogs, and gall-bladder neoplasia in 20/59 dogs that did not have these pathologies. Contrast-enhanced ultrasound correctly identified cholecystitis/edema in 42/47 dogs, but falsely identified cholecystitis/edema in three of 18 dogs. It correctly identified necrosis/rupture, benign polypoid lesions, and gallbladder neoplasia in all dogs with no false-positive results. Findings supported contrast-enhanced ultrasound as a complement to conventional ultrasonography for dogs with suspected gallbladder pathologies such as edema, necrosis, and rupture.

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“…Adipokines, including leptin, adiponectin and resistin, are biologically active substances that are secreted mainly from mature adipose tissue, playing important roles in the regulation of the lipid and carbohydrate metabolism [11,12]. Because leptin primarily works as a fasting hormone thorough the regulation of food intake and energy consumption, plasma leptin levels are quantitative markers of obesity in humans, dogs and rodents [13,14]. It is known that circulating leptin levels correlate positively with adipose tissue mass and body condition scores [14].…”

Section: Discussionmentioning

confidence: 99%

“…It is known that adiponectin contributes to increased insulin sensitivity, reduced blood glucose and reduced tissue TG levels in the liver and muscle [14]. Resistin promotes inflammation and regulates the secretion of proinflammatory cytokines such as TNF-α and interleukin-6 (IL-6) [11][12][13][14][15]. However, there was only a slight change in adiponectin and no change in resistin over the study period.…”

Section: Discussionmentioning

confidence: 99%

Effects of a Watermelon Extract Beverage on Canine Lipid Metabolism and Urine Crystals

Miyai¹

2018

AVS

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Previous report showed that watermelon consumption has an anti-obesity effects in rats. The purpose of this study is to examine the effects on body weight, body fat percentage, serum biochemical data, serum adipokine concentrations (leptin, adiponectin, and resistin), urine specific gravity and sediments when 12 dogs were given watermelon extract beverage instead of water for 3 months. Those data were all assessed before the study period and again at 1.5 and 3 months. Although there were no remarkable changes in most of these parameters, a significant decrease in serum leptin concentrations at 1.5 and 3 months. Calcium oxalate and struvite crystals were observed in the urinary sediment in five dogs; although their urine specific gravities remained >1.040 throughout, the number of urinary crystals had decreased by the end of the 3-month period. Morphological components were not found in the urinary sediment of the other five dogs; their urine specific gravities were also >1.040 before the study period and at 1.5 months, but these had decreased to <1.040 at 3 months. These results suggested that drinking the watermelon extract beverage reduced serum leptin levels and inhibited the formation of urine crystals such as calcium oxalate and struvite crystals in dogs.

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Increased Leptin and Leptin Receptor Expression in Dogs With Gallbladder Mucocele

Cited by 20 publications

References 39 publications

Gall bladder mucoceles in Border terriers

Gall bladder mucoceles in Border terriers

Contrast‐enhanced ultrasound complements two‐dimensional ultrasonography in diagnosing gallbladder diseases in dogs

Effects of a Watermelon Extract Beverage on Canine Lipid Metabolism and Urine Crystals

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