Increased leukocyte ABCA1 gene expression in post-menopausal women on hormone replacement therapy

Darabi, Maryam; Rabbani, Mohammad; Ani, Mohsen; Zarean, Elahe; Panjehpour, Mojtaba; Ahmad, Mansoor

doi:10.3109/09513590.2010.507826

Cited by 21 publications

(24 citation statements)

References 29 publications

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“…The effects on serum lipid composition found after the HRT agree with previous studies [16] and has been discussed earlier by us [9].…”

Section: Blood Sampling and Analysissupporting

confidence: 91%

“…The mean age at menopause in the population was 46.5±3.7 years. Details of the study design and sampling have been reported earlier [9]. Briefly, Women were considered postmenopausal if they had no menstrual periods for at least 12 months and serum follicle-stimulating hormone (FSH) of >35 IU/L without other obvious pathological or physiological cause.…”

Section: Subjectsmentioning

confidence: 99%

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Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

et al. 2010

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“…The effects on serum lipid composition found after the HRT agree with previous studies [16] and has been discussed earlier by us [9].…”

Section: Blood Sampling and Analysissupporting

confidence: 91%

Section: Subjectsmentioning

confidence: 99%

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

et al. 2010

Self Cite

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“…Although the cause of sex-related differences is not fully understood, estrogen is known to have an effect in premenopausal women by increasing HDL-C concentrations (37,38). Moreover, there is evidence that estrogen increases ABCA1 expression in different tissues (39,40) and estrogen therapy increases ABCA1 expression in leukocytes and improves lipid profile in menopausal women (41), suggesting that the sexspecific interaction here could be mediated by the effect of estrogen on ABCA1 expression. On the other hand, although testosterone is known to be responsible for lowering HDL-C levels in men (42), this hormone has been found not to affect apoA-I or ABCA1 expression in hepatocytes or human monocyte-derived macrophages (43), which is consistent with the lack of ABCA1-nutrient interaction observed in males.…”

Section: Discussionmentioning

confidence: 99%

Carbohydrate Intake Modulates the Effect of the ABCA1 -R230C Variant on HDL Cholesterol Concentrations in Premenopausal Women

Romero‐Hidalgo

Villarreal-Molina

González-Barrios

et al. 2012

The Journal of Nutrition

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The R230C variant of the ATP-binding cassette transporter A1 (ABCA1) gene has been consistently associated with decreased HDL-cholesterol (HDL-C) concentrations in several studies in the Mexican mestizo population. However, information on how diet composition modifies the effect of the ABCA1-R230C variant on HDL-C concentrations is very scarce. The aim of the present study was to analyze whether the effect of ABCA1-R230C on HDL-C concentrations is modulated by dietary factors in a nationwide population sample of 3591 adults from the National Health and Nutrition Survey conducted by the State's Employees' Social Security and Social Services Institute. All participants answered a validated questionnaire to assess health status and weekly food consumption. Fasting blood samples were drawn for biochemical analysis and DNA extraction, and the ABCA1-R230C variant was genotyped using TaqMan assays. Statistical analyses consisted of simple linear and multiple regression modeling adjusting for age, BMI, smoking, and alcohol consumption. The overall C risk allele frequency was 9.3% and the variant was significantly associated with low HDL-C concentrations in both sexes. A significant negative correlation between carbohydrate consumption and HDL-C concentrations was observed in women bearing the R230C variant (P = 0.021) and a significant gene-diet interaction was found only in premenopausal women (P = 0.037). In conclusion, the effect of the ABCA1-R230C gene variant on HDL-C concentrations is modulated by carbohydrate intake in premenopausal women. This finding may help design optimized dietary interventions according to sex and ABCA1-R230C genotype.

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“…ABCA1, CCL5 and FASLG have been previously shown to associate with HRT and menopause (Christodoulakos et al, 2007;Darabi, Rabbani et al, 2011;Kangas et al, 2014), and both UHRF1 and PPP2R2B…”

Section: This Analysis Revealed That Five Genes With Dmrs (Abca1 Uhrmentioning

confidence: 99%

Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adiposity and Bone Mass

et al. 2015

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The loss of estrogen during menopause causes changes in the female body with wide-range effects on health. Estrogen-containing hormone replacement therapy (HRT) leads to a relief of typical menopausal symptoms, benefits bone and muscle health, and associates with tissue-specific gene expression profiles. As gene expression is controlled by epigenetic factors (including DNA methylation) many of which are environmentally sensitive, it is plausible that at least part of the HRT-associated gene expression is due to changes in DNA methylation profile.We investigated genome-wide DNA methylation and gene expression patterns of white blood cells (WBCs) and their associations with body composition, including muscle and bone measures of monozygotic female twin pairs discordant for HRT. We identified 7855 differentially methylated regions (DMRs) associated with 4044 genes. Of the genes with DMRs, five (ACBA1, CCL5, FASLG, PPP2R2B and UHRF1) were al so differenti ally expressed. All have been previously associated with HRT or estrogenic regulation, but not with HRT-associated DNA methylation. All five genes were associated with bone mineral content, and ABCA1, FASLG and UHRF1 were also associated with body adiposity.

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Increased leukocyte ABCA1 gene expression in post-menopausal women on hormone replacement therapy

Abstract: The beneficial cardiovascular effects of HRT could be explained, at least in part, by increasing the ABCA1 gene expression.

Cited by 21 publications

References 29 publications

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

Effect of hormone replacement therapy on total serum anti-oxidant potential and oxidized LDL/.BETA.2-glycoprotein I complexes in postmenopausal women

Carbohydrate Intake Modulates the Effect of the ABCA1 -R230C Variant on HDL Cholesterol Concentrations in Premenopausal Women

Hormone Replacement Therapy Associated White Blood Cell DNA Methylation and Gene Expression are Associated With Within-Pair Differences of Body Adiposity and Bone Mass

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