Increased lung signal as a hint of COVID-19 infection on Tc-99m-sestamibi myocardial perfusion scintigraphy

Delabie, Pierre; Hyafil, Fabien

doi:10.1007/s12350-020-02197-y

Cited by 6 publications

(5 citation statements)

References 3 publications

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“…Patients 1 [ 24 ] and 3 [ 25 ] were referred for exercise SPECT MPI following dyspnea on exertion (DOE), which was reported to be normal. In the CTAC of patient 1, bilateral GGOs were seen in the inferior lobes.…”

Section: Resultsmentioning

confidence: 99%

Myocardial perfusion imaging in the era of COVID-19: a systematic review

Hassanzadeh

Neshat

Heidari

et al. 2022

Clin Transl Imaging

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Purpose As COVID-19 was uncovered, it became evident that specific individuals could experience multi-organ complications for quite a while after infection. Among them, there were several cardiovascular complications. Myocardial perfusion imaging single photon emission computed tomography (MPI SPECT) can be utilized to detect and evaluate cardiac problems regardless of whether COVID caused them. By examining all publications relevant to the impacts of the pandemic on SPECT MPI imaging, we aimed to understand how the COVID pandemic affected different aspects of the MPI, how intense these effects were, and what the consequences were. Method On the 6th of June, 2022, a four-domain search strategy was developed and implemented by searching the following databases: PubMed, SCOPUS, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials. The retrieved records have been put through two levels of screening. The search for forward and backward citations provided more results. Results This study contained 32 papers, divided into the following three categories: 1. Case reports and series; 2. A comparison of the number of MPIs conducted before and after the pandemic; and 3. SPECT MPI findings. Conclusion We observed through the article review that CT scans performed in combination with MPI are crucial and should be interpreted within the context of COVID, especially during outbreaks. Moreover, we discovered that in the initial months of the pandemic, the number of SPECT MPIs performed globally decreased, with the fall being more significant in some countries, primarily in low- to middle-income regions. Lastly, we found that individuals with a history of COVID-19 may be more prone to having MPIs that demonstrate abnormalities, such as ischemia. Graphical abstract

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Section: Resultsmentioning

confidence: 99%

Myocardial perfusion imaging in the era of COVID-19: a systematic review

Hassanzadeh

Neshat

Heidari

et al. 2022

Clin Transl Imaging

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“… 1 Thorough inspection of rotating raw and reconstructed images may not only lead to discovery of important non-cardiac disorder but also provide a hint of coronavirus disease 2019 (COVID-19) during its outbreak. 2 We report a challenging finding of multifocal pulmonary uptake in an asymptomatic patient with typical features of pulmonary involvement with COVID-19 infection, incidentally noticed in SPECT MPI.…”

Section: Back Groundmentioning

confidence: 88%

Extra-cardiac multifocal lung uptake of 99mTc-sestamibi in myocardial perfusion imaging: An asymptomatic case with coronavirus infection features

Malek

Maghsudi

Yaghoobi

2022

Journal of Nuclear Cardiology

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“…The capability of sestamibi to identify malignant lesions by SPECT analysis has been shown for several human diseases such as hearth injury, breast cancer renal carcinomas, and PHP [ 29 , 30 , 31 , 32 , 33 ]. Indeed, numerous investigations demonstrated a close association between positive [ 99 mTc]Sestamibi analysis and the severity of disease [ 29 , 30 , 31 , 32 , 33 ]. However, few studies correlated the sestamibi uptake with the histopathological characteristics of human lesions [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

[99mTc]Sestamibi SPECT Can Predict Proliferation Index, Angiogenesis, and Vascular Invasion in Parathyroid Patients: A Retrospective Study

Urbano

Scimeca

Russo

et al. 2020

JCM

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The aim of this study was to evaluate the possible association among sestamibi uptake and the main histopathological characteristics of parathyroid lesions related to aggressiveness such as the proliferation index (Ki67 expression and mitosis), angiogenesis (number of vessels), and vascular invasion in hyperparathyroidism patients. To this end, 26 patients affected by primary hyperparathyroidism subjected to both scintigraphy with [99mTc]Sestamibi and surgery/bioptic procedure were retrospectively enrolled. Hyperfunctioning of the parathyroid was detected in 19 patients. Our data showed a significant positive association among the sestamibi uptake and the proliferation index histologically evaluated both in terms of the number of Ki67 positive cells and mitosis. According to these data, lesions with a higher valuer of L/N (lesion to nonlesion ratio) frequently showed several vessels in tumor areas and histological evidence of vascular invasion. It is noteworthy that among patients with negative scintigraphy, 2 patients showed a neoplastic lesion after surgery (histological analysis). However, it is important to highlight that these lesions displayed very low proliferation indexes, which was evaluated in terms of number of both mitosis and Ki67-positive cells, some/rare vessels in the main lesion, and no evidence of vascular invasion. In conclusion, data obtained on patients with positive or negative scintigraphy support the hypothesis that sestamibi can be a tracer that is capable of predicting some biological characteristics of parathyroid tumors such as angiogenesis, proliferation indexes, and the invasion of surrounding tissues or vessels.

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Increased lung signal as a hint of COVID-19 infection on Tc-99m-sestamibi myocardial perfusion scintigraphy

Cited by 6 publications

References 3 publications

Myocardial perfusion imaging in the era of COVID-19: a systematic review

Myocardial perfusion imaging in the era of COVID-19: a systematic review

Extra-cardiac multifocal lung uptake of 99mTc-sestamibi in myocardial perfusion imaging: An asymptomatic case with coronavirus infection features

[99mTc]Sestamibi SPECT Can Predict Proliferation Index, Angiogenesis, and Vascular Invasion in Parathyroid Patients: A Retrospective Study

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