Increased macrophage activity in psoriasis

Koh, MS; Majewski, BB; Rhodes, EL.

doi:10.2340/0001555565194198

Cited by 7 publications

(1 citation statement)

References 9 publications

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“…137 Marble et al found that the number of macrophages increased in the lesions of psoriasis patients and decreased to non-lesional skin levels after effective treatment with TNF-α inhibitors. 44,138 In another study, Koh et al reported that the activity of macrophages were increased in the lesional skin of patients with psoriasis, 139 suggesting the involvement of macrophages in psoriasis.…”

Section: Dovepressmentioning

confidence: 99%

Cellular Mechanisms of Psoriasis Pathogenesis: A Systemic Review

Wu,

Dai,

Zeng

2023

CCID

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Psoriasis is a common inflammatory skin disease characterized by abnormal proliferation of epidermal keratinocytes and massive infiltration of inflammatory cells. Many kinds of cells, including keratinocytes, T lymphocytes, dendritic cells, neutrophils, and macrophages, are reported to play critical roles in the pathogenesis and progression of psoriasis. However, to date, the role of each kind of cell in the pathogenesis and development of psoriasis has not been systematically reviewed. In addition, although antibodies developed targeting cytokines (e.g. IL-23, IL-17A, and TNF-α) released by these cells have shown promising results in the treatment of psoriasis patients, these targeted antibodies still do not cure psoriasis and only provide short-term relief of symptoms. Furthermore, long-term use of these antibodies has been reported to have adverse physical and psychological effects on psoriasis patients. Therefore, gaining a deeper understanding of the cellular and molecular pathogenesis of psoriasis and providing new thoughts on the development of psoriasis therapeutic drugs is of great necessity. In this review, we summarize the roles of various cells involved in psoriasis, aiming to provide new insights into the pathogenesis and development of psoriasis at the cellular level and hoping to provide new ideas for exploring new and effective psoriasis treatments.

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Section: Dovepressmentioning

confidence: 99%

Cellular Mechanisms of Psoriasis Pathogenesis: A Systemic Review

Wu,

Dai,

Zeng

2023

CCID

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Macrophages in dermatology: pathogenic roles and targeted therapeutics

et al. 2021

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Anthralin (dithranol)in vitroinhibits human monocytes to secrete IL-6, IL-8 and TNF-α, but not IL-1

Mrowietz

JESSAT

Schwarz

et al. 1997

British Journal of Dermatology

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Anthralin is a most widely used compound for topical treatment of psoriasis. Whereas numerous studies have ascertained anthralin as a safe and effective drug its mode of action still remains unclear. Previous studies demonstrated dose-dependent inhibition of a number of pro-inflammatory functions in human neutrophils and monocytes (MO). The aim of the present study was to investigate in stimulated MO the effect of anthralin on the secretion of cytokines which are of known importance for the psoriatic tissue reaction. Highly purified MO were incubated with anthralin (0.01-1.0 microgram/ml), its clinically inactive derivative danthrone (0.1 and 10 micrograms/ml), the solvent acetone, or medium alone. Culture supernatants were analysed for immunoreactivity for interleukin-1 beta, and -8 (IL-1 beta, IL-8), and tumour necrosis factor alpha (TNF-alpha) by specific ELISA. IL-6 bioactivity was determined using the B9-bioassay. Additionally, IL-1 bioactivity was measured by the D10[N4]M-bioassay. The results show a dose-dependent inhibition of MO IL-6, IL-8, and TNF-alpha release with a half-maximal inhibitory concentration of 0.25-0.6 microgram/ml of anthralin. There was no effect of danthrone or acetone on the secretion of these cytokines from MO. Secretion of IL-1 beta immunoreactivity measured by ELISA as well as determination of biological activity of IL-1 using the D10[N4]M-bioassay revealed a slight increase in IL-1 secretion with a maximum at an anthralin concentration of 0.1 microgram/ml. Danthrone at a concentration of 10 micrograms/ml and acetone (0.1%) similarly enhanced IL-1 secretion from human MO measured by both methods. Our results demonstrate a differential, dose-dependent inhibition of cytokine secretion from human MO by anthralin. The present data provide evidence that the anti-inflammatory and anti-proliferative activity of anthralin may at least in part be due to its inhibitory effect on pro-inflammatory cytokine secretion by MO.

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Increased macrophage activity in psoriasis

Abstract: Macrophages derived from circulating blood monocytes of psoriatic patients demonstrated an enhanced release of beta-glucuronidase and lysozyme compared with macrophages from healthy subjects. The relationship of cell activation to the pathogenesis of psoriasis is discussed.

Cited by 7 publications

References 9 publications

Cellular Mechanisms of Psoriasis Pathogenesis: A Systemic Review

Cellular Mechanisms of Psoriasis Pathogenesis: A Systemic Review

Macrophages in dermatology: pathogenic roles and targeted therapeutics

Anthralin (dithranol)in vitroinhibits human monocytes to secrete IL-6, IL-8 and TNF-α, but not IL-1

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