Increased Mast Cell Counts in Benign and Malignant Salivary Gland Tumors

Jaafari‐Ashkavandi, Zohreh; Ashraf, Mohammad Javad

doi:10.5681/joddd.2014.003

Cited by 3 publications

(1 citation statement)

References 26 publications

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“…It is easy to understand that the cytological observations cannot specify the tissue localization of mast cells, but only signal the increased incidence of these cells and their association with the benign nature of the proliferation (33,34). Despite these limitations, the presence of mast cells in Warthin's tumor has been associated with several clinicopathological features: increased mast cell density was correlated with favorable prognosis, mast cell degranulation was associated with lymphoid follicle formation, and mast cells were associated with the benign nature of Warthin's tumor (35).…”

Section: Discussionmentioning

confidence: 99%

High Intraepithelial Mast Cell Density in Warthin’s Tumor

COSOROABA,

CEAUSU,

GAJE

et al. 2024

In Vivo

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Section: Discussionmentioning

confidence: 99%

High Intraepithelial Mast Cell Density in Warthin’s Tumor

COSOROABA,

CEAUSU,

GAJE

et al. 2024

In Vivo

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Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands

Souza

Oliveira

Nonaka

et al. 2017

Eur Arch Otorhinolaryngol

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This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody. Higher GLUT-1 immunoexpression was observed in the MECs compared to PAs and ACCs (p = 0.022). Mean number of microvessels was 66.5 in MECs, 40.4 in PAs, and 21.2 in ACCs (p < 0.001). GLUT-1 expression and angiogenic index showed no significant correlation in the tumors studied. Results suggest that differences in biological behavior of the studied tumors are related to GLUT-1. Benign and malignant salivary gland tumors differ in the angiogenic index; however, angiogenesis may be independent of the tumor cell's metabolic demand.

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Cytomorphological findings in diagnosis of Warthin tumor

et al. 2020

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Background/aim: To define the cytomorphologic findings leading to difficulties in diagnosis of Warthin tumors (WTs). Materials and methods: Forty-eight histopathologically diagnosed WT patients who had fine needle aspiration cytology preoperatively were reevaluated for defining the presence or absence of lymphocytes, oncocytic cell layer, oncocytic cell papillae, granular debris background, mucoid background, macrophages, polymorphonuclear cells, mast cells, squamous-like cells, atypical vacuolated cytoplasmic cells, and giant cells. Results: Forty-seven tumors were in the parotid gland and one in the submandibular gland. There were 37 (77%) male and 11 (23%) female patients. Cytopathologically in 36 patients the diagnosis was benign neoplasm (WT); in 6, other benign entities; and in 6, suspicious for malignancy. The main characteristic cytomorphologic features of WTs were as follows: 92% lymphoid cells, 83% oncocytic cell layers, and 67% granular debris background. These percentages were 67%, 17%, and 17% in the benign cytology group and 67%, 50%, and 17% in the suspicious for malignancy group, respectively. Conclusion: Absence or lack of main features of WTs with or without presence of squamous-like cells, vacuolated cytoplasmic cells, and inflammatory reaction may cause diagnostic dilemma. The presence of the mast cells accompanied by epithelial tissue was striking for WT diagnosis.

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Increased Mast Cell Counts in Benign and Malignant Salivary Gland Tumors

Cited by 3 publications

References 26 publications

High Intraepithelial Mast Cell Density in Warthin’s Tumor

High Intraepithelial Mast Cell Density in Warthin’s Tumor

Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands

Cytomorphological findings in diagnosis of Warthin tumor

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