Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia

Austgulen, Rigmor; Lien, Egil; Vince, Gill; Redman, C.W.G.

doi:10.1016/s0301-2115(96)02647-4

Cited by 147 publications

(124 citation statements)

References 26 publications

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“…[22][23][24] Even significantly lower sICAM-1 values in preeclampsia have been reported. 25 These conflicting results might derive from the small number of patients studied or from the observed large variations of sICAM-1 concentrations, as in our study.…”

Section: Discussionmentioning

confidence: 96%

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

et al. 2000

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OBJECTIVES:Maternal serum soluble vascular cell adhesion molecule-1 (sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) were evaluated in preeclampsia to investigate whether these molecules could be helpful with regard to this pregnancy complication. STUDY DESIGN:The study population was composed of 30 preeclamptic patients with a mean gestational age of 35.5 Ϯ 4.6 weeks and 20 age-matched and gestational age-matched normotensive uncomplicated pregnancies (controls). Blood samples from 7 of the 30 preeclamptic patients and 15 of the 20 controls in the second trimester were also analyzed. Data were analyzed by parametric methods. RESULTS:Significantly higher maternal serum sVCAM-1 levels were found in both groups of preeclamptic patients with and without fetal growth restriction (981 Ϯ 145 ng/ml; n ϭ 13; p Ͻ 0.0005 and 846 Ϯ 84 ng/ml; p Ͻ 0.02, respectively) compared with controls (668 Ϯ 186 ng/ml). In contrast, no significant difference was found in maternal serum sICAM-1 levels between preeclamptic and normotensive pregnancies, or in both adhesion molecules (1) in the controls between second and third trimester samples and (2) in the second trimester between pregnant women who developed preeclampsia later and gestational age-matched controls. CONCLUSION:These findings show a selective significant elevation of maternal serum sVCAM-1 in preeclampsia, with the highest values in cases complicated with fetal growth restriction, perhaps reflecting its angiogenic function. Hence, sVCAM-1 could be helpful in the diagnosis of this fetal complication in preeclampsia.

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Section: Discussionmentioning

confidence: 96%

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

et al. 2000

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“…Determination of both serum urea and creatinine excluded other renal causes of proteinuria than the preeclampsia. 2 and TXA 2 levels Serum ET-1 and plasma TXA 2 levels in normal pregnant women at high altitude showed a significant elevation (66.81 ± 7.36 pg/ml, 122.86 ± 13.37 pg/ml, respectively) compared with the normal pregnant women at low altitude (48.92 ± 4.58 pg/ml, 89.03 ± 10.67 pg/ml). Preeclampsia in low altitude produced significant increases in both serum ET-1 and plasma TXA 2 levels (88.39 ± 9.54 pg/ml, 162.73 ± 15.92 pg/ml, respectively) compared with both the NL and NH groups.…”

Section: Determination Of Blood Pressurementioning

confidence: 89%

“…Exaggerated inflammatory responses were believed to be a significant pathophysiological event during preeclampsia (25). Several biochemical parameters indicate that endothelial dysfunction is related to the inflammatory response in preeclampsia, such as elevated serum cellular fibronectin, endothelial adhesion molecules P-selectin, the intercellular adhesion molecule, the vascular cell adhesion molecule, and the platelet endothelial cell adhesion molecule levels (2,19,21,31,33). A previous study reported that the pro-inflammatory cytokines increased significantly in preeclamptic women compared to women with normal pregnancies at sea level (28).…”

Section: Discussionmentioning

confidence: 99%

The effect of high altitude on endothelial and vascular dysfunction markers in preeclamptic patients

So¹,

Suekit²,

Ao³

et al. 2015

Acta Physiologica Hungarica

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Placental hypoxia, a major component of the pathophysiology of preeclampsia, is associated with various maternal vascular and endothelial dysfunctions. The higher incidence of preeclampsia at high altitude remains incompletely explained. The aim of the present study was to investigate the effect of high altitude on some endothelial and vascular dysfunction markers in normal and preeclamptic pregnancies. Eighty pregnant women (Paras 2-4) were enrolled in this study, which included four groups (each n = 20): normal pregnancies at low altitude (NL), normal pregnancies at high altitude (NH), preeclamptic pregnancies at low altitude (PL), and preeclamptic pregnancies at high altitude (PH). In normal pregnancies at high altitude serum ET-1, plasma TXA 2 , and serum TNF-α levels increased significantly with a significant reduction in plasma PGI 2 (66.81 ± 7.36, 122.86 ± 13.37, 102.23 ± 13.31, 191.57 ± 19.68, respectively) compared with the NL group (48.92 ± 4.58, 89.03 ± 10.67, 69.86 ± 7.97, 238.01 ± 24.55, respectively). In preeclampsia at low altitude serum ET-1, plasma TXA 2 , and serum TNF-α levels increased significantly with a significant reduction in plasma PGI 2 (88.39 ± 9.54, 162.73 ± 15.92, 142.39 ± 15.37, 149.155 ± 15.66, respectively) compared with both NL and NH groups. High altitude significantly augmented these changes in preeclamptic patients (117.75 ± 12.96, 211.01 ± 22.69, 196.86 ± 17.64, 111.92 ± 10.74) compared with PL, NH and NL groups. In conclusion hypoxia at high altitude aggravated the disturbances in the levels of ET-1, TXA 2 , PGI 2 and TNF-α associated with preeclampsia. This may contribute to the higher risk of preeclampsia at high altitude.

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“…[25][26][27] Patients were matched for parity, ethnicity, and gestational age, so that blood samples were obtained at the same week of gestation for preeclamptic patients and controls. Patients were recruited at the Nuffield Department of Obstetrics and Gynaecology, Oxford University, after the Central Oxfordshire Ethics Committee approved the study and written, informed consent was obtained.…”

Section: Methodsmentioning

confidence: 99%

Prevalence of Agonistic Autoantibodies Against the Angiotensin II Type 1 Receptor and Soluble fms-Like Tyrosine Kinase 1 in a Gestational Age–Matched Case Study

et al. 2009

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Abstract-We showed earlier that activating autoantibodies against the angiotensin II type 1 (AT 1 ) receptor (AT1-AA) circulate in preeclamptic women. They may be involved in the pathogenesis of preeclampsia. Protein alignment suggests that the binding site for AT1-AAs is highly homologous to the capsid protein VP2 of parvovirus B19. We performed a prospective, nested, case-control study of 30 gestational age-matched women with preeclampsia and 30 normotensive pregnant women. We measured AT1-AA, soluble fms-like tyrosine kinase 1 (sFlt-1), and serum immunoglobulin G against parvovirus B19 proteins. AT1-AAs were present in 70% of preeclamptic patients and absent in 80% of controls. Prediction by AT1-AA was improved in late-onset preeclampsia. The discrimination for sFlt-1 was 96%. We did not find an interaction between sFlt-1 and AT1-AA. A human monoclonal immunoglobulin G antibody against parvovirus B19 VP2-protein showed a positive reaction in the AT1-AA bioassay, which could be blocked by an AT 1 receptor blocker, as well as by the epitope amino acid sequence. Immunoglobulin G against parvovirus B19 proteins was similarly distributed between preeclamptic patients and controls and had no significant importance. We detected significantly more AT1-AA in women with an immune response corresponding with parvovirus B19 infection corresponding with a distant viral infection associated with virus elimination. We concluded that AT1-AAs were common in patients with preeclampsia in a prospective case-control study, although sFlt-1 was a superior biomarker. AT1-AA may represent a better marker for late disease, whereas sFlt1 is a better marker for early onset disease. Key Words: preeclampsia Ⅲ activating autoantibodies Ⅲ angiogenesis Ⅲ parvovirus B19 Ⅲ molecular mimicry P reeclampsia is defined as new-onset hypertension after 20 weeks' gestation accompanied by new-onset proteinuria; the condition causes acute morbidity and mortality. 1,2 The incidence is 2% to 5% worldwide and is associated with subsequent cardiovascular diseases in both mother and child. 3 The pathogenesis is unknown but is likely to be multifactorial. 4 We described circulating autoantibodies directed at the second extracellular loop of the angiotensin (Ang) II type 1 (AT 1 ) receptor (AT1-AA) in women with preeclampsia. 5 AT1-AAs induce reactive oxygen species, inhibit trophoblast migration, and occur in rat models. 6 -8 AT1-AAs induced preeclampsia-like symptoms in C57BL/6J mice by passive transfer. 9 However, AT1-AAs are not specific for preeclampsia and also occur in patients with humoral kidney transplant rejection. 10 An epitope on the second extracellular loop of the human AT 1 receptor (AFHYESQ) represents the binding site for AT1-AAs; the same sequence inhibits the AT1-AAmediated effects completely in vivo and in vitro. The epitope is highly homologous to the capsid protein VP2 from parvovirus B19 (AFHYETQ).Parvovirus B19 is a single-stranded DNA virus and can cause erythema infectiosum, a generally (but not always) mild childhood exanthem. 11,...

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Increased maternal plasma levels of soluble adhesion molecules (ICAM-1, VCAM-1, E-selectin) in preeclampsia

Cited by 147 publications

References 26 publications

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

A Comparative Study of Serum Soluble Vascular Cell Adhesion Molecule-1 and Soluble Intercellular Adhesion Molecule-1 in Preeclampsia

The effect of high altitude on endothelial and vascular dysfunction markers in preeclamptic patients

Prevalence of Agonistic Autoantibodies Against the Angiotensin II Type 1 Receptor and Soluble fms-Like Tyrosine Kinase 1 in a Gestational Age–Matched Case Study

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