Increased mean glucose levels in patients with polycystic ovary syndrome and hyperandrogenemia as determined by continuous glucose monitoring

Zhu, Jiaan; Teng, Yincheng; Zhou, Jian; Lü, Wei; Tao, Minfang; Jia, Weiping

doi:10.1111/aogs.12031

Cited by 18 publications

(9 citation statements)

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“…The hormonal changes negatively affect or stop the maturation of follicles, leading to anovulation [37]. Letrozole-induced PCOS model is a good method because animals developed many characteristics of human PCOS, including hyperandrogenism and abnormal follicles [11], hyperglycemia [13], and oxidative stress [9]. As expected, we observed in the current study that letrozole easily induced PCOS in rats after 21 days of continuous administration.…”

Section: Discussionsupporting

confidence: 76%

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Phyllanthus muellerianus(Euphorbiaceae) Restores Ovarian Functions in Letrozole-Induced Polycystic Ovarian Syndrome in Rats

Ndeingang

Deeh

Watcho

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Polycystic ovarian syndrome (PCOS) is one of the common causes or female infertility. Phyllanthus muellerianus (Euphorbiaceae) is a plant used to treat various ailments including frequent menstruation and anovulation. We investigated the effects of P. muellerianus extracts on estrus cyclicity, lipid profile, oxidative stress-related markers, sex hormones, and ovarian architecture in letrozole-induced PCOS in rats. After induction of PCOS using letrozole (1 mg/kg/day), normal (n=6), and PCOS (n=108; distributed into 18 groups of 6 animals/group) rats were treated orally for 7 or 14 days with distilled water (10 ml/kg/day), clomiphene citrate (2 mg/kg/day), metformin (500 mg/kg/day), and aqueous or methanolic extract of P. muellerianus (30, 60, and 120 mg/kg). Estrus cyclicity, body, and sexual organ (ovaries and uterus) weights, biochemical and histological parameters were measured. There were letrozole-induced PCOS characterized by irregular estrus cyclicity, elevated (p<0.05-0.01) glycaemia, ovarian weight, triglycerides, total cholesterol, LDL cholesterol, VLDL cholesterol, malondialdehyde, luteinizing hormone (LH), and testosterone concentrations, but there were low (p<0.05-0.001) HDL cholesterol, estradiol, progesterone, catalase, peroxidase, and superoxide dismutase levels, compared with control. PCOS rats had multiple cysts compared with control. These reproductive, biochemical, and structural alterations were alleviated by P. muellerianus extracts. For instance, P. muellerianus restored the estrus cyclicity with a remarkable effect after 14 days of treatment. Moreover, P. muellerianus significantly decreased (p<0.001) LH and testosterone (both extracts; 30, 60, and 120 mg/kg) levels, but increased (p<0.01) estradiol (aqueous extract; 60 mg/kg) concentration. Cystic follicles were also decreased after plant application. P. muellerianus alleviated reproductive, hormonal, and structural alterations in PCOS rats. This plant could be useful in the management/treatment of reproductive and metabolic disorders related to PCOS.

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Section: Discussionsupporting

confidence: 76%

“…Previous reports have shown that letrozole is efficient in establishing PCOS in rats [11, 12]. These animals developed many characteristics of human PCOS, including abnormal follicles [11], hyperglycemia [13], oxidative stress [9], and altered sex hormones (testosterone, estrogens, LH and FSH) levels [11].…”

Section: Introductionmentioning

confidence: 99%

Phyllanthus muellerianus(Euphorbiaceae) Restores Ovarian Functions in Letrozole-Induced Polycystic Ovarian Syndrome in Rats

Ndeingang

Deeh

Watcho

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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“…Lipid metabolism indexes included total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL). Total cholesterol TC was involved in 18 [ 7 , 11 , 12 , 14 – 16 , 18 – 20 , 22 , 24 – 26 , 29 – 32 , 34 , 35 ] out of the included articles (a total of 3920 PCOS patients, including 2856 cases in the PCOS/HA group and 1064 cases in the PCOS/NHA group). Meta-analysis was performed using the random effect model due to heterogeneity among different studies ( P = 0.002, I 2 = 56.6 %), and the results showed that the difference of TC was not statistically significant between the PCOS/HA and PCOS/NHA groups [SMD = 0.05, 95 % CI (−0.09,0.18), P = 0.494].…”

Section: Resultsmentioning

confidence: 99%

Effects of hyperandrogenism on metabolic abnormalities in patients with polycystic ovary syndrome: a meta-analysis

Yang

et al. 2016

Reprod Biol Endocrinol

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BackgroundThe study evaluated the effect of hyperandrogenism (HA) in polycystic ovary syndrome (PCOS) on metabolic parameters.MethodsWe searched PubMed, EMBASE, Cochrane, Web of Science, Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), WanFang data and VIP for clinical observational studies. The study evaluated PCOS patients with or without HA on metabolic parameters was included. Prevalence of metabolic syndrome, indexes of insulin resistance (IR) including homeostasis model assessment IR index (HOMA-IR), incidence of IR, biomarkers of serum lipid metabolism such as total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL), and low density lipoprotein (LDL).ResultsOf 4457 identified trials, 32 observational studies were included for the final analysis comprising 9556 female with PCOS. 6482 cases were having HA, and the others were negative. There were significant differences in the incidence of metabolic syndrome, HOMA-IR, rate of IR, TC level and HDL level between PCOS patients with or without HA, except for LDL level. No significant publication bias was found as P value of Egger’s test was 0.82.ConclusionsHA play an important role in metabolic disorders in PCOS patients. The incidence of metabolic syndrome, IR indexes, and most biomarkers of serum lipid metabolism were significantly different between patients with and without HA.

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“…A systematic search for these states of hyperglycaemia would be essential for women with this syndrome in our environment. The results of studies show that the prevalence of metabolic syndrome in women with PCOS is between 34% and 46% according to the studies [5] [20] [45] [46] [47] [48]. In the study by Alessandra G. et al [47], there was a significantly higher prevalence of diabetes mellitus in women with PCOS compared to healthy women of the same age (39.3% vs. 5.8%).…”

Section: ) Frequency Of Hyperglycemia In Congolese Patients With Pcosmentioning

confidence: 99%

“…Although its pathophysiology isn't still well known, diet seems to play an important role in the genesis of this affection. Numerous studies have shown that hyperglycemic states, even apart from proven diabetes, would be a risk factor for the occurrence of this syndrome by complex mechanisms [3] [4] [5]. A high percentage of affected women have abnormalities of carbohydrate metabolism [6].…”

Section: Introductionmentioning

confidence: 99%

Importance of the Glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A Case-Control Study in Kinshasa, DR Congo

Numbi¹,

Beya²,

Luzolo³

et al. 2019

OJOG

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Context: Polycystic ovary syndrome (PCOS) is considered a syndrome related to the metabolic syndrome with a high risk for developing diabetes mellitus. The evaluation of the glycated hemoglobin (HbA1c) seems to be an interesting tool to detect states of hyperglycemia that may be associated with this syndrome and to understand her pathophysiology. Aims: The purposes of this study are to determine the profile of HbA1c in Congolese women with PCOS, to determine the frequency of states of hyperglycemia and to assess the impact of this marker on clinical signs on this syndrome. Material and methods: This is a case-control study of 130 Congolese subfertile women; 65 with a diagnosis of PCOS and 65 others without PCOS. This is conducted from June 2016 to June 2019 among Congolese women of childbearing age.How to cite this paper:All these women were recruited at the subfertility outpatient clinic of the University Hospital of UNIKIN as well of the YANGA medical centers in Kinshasa, Democratic Republic of Congo. Sickle cell disease was excluded as also the cases of anemia. HbA1c was assayed via the immunoturbidimetric method and the results interpreted according to the ADA recommendations with a pathological cut-off point ≥ 6.5%. Results: Mean hemoglobin was 11.6 ± 1.2 g/dl (11.5 ± 1.1 g/dl vs. 11.8 ± 1.4 g/dl, P = 0.568). The proportion of diabetics was 1.6% (1.6% vs. 1.5%, P = 0.74). Higher HbA1c values were noted in the PCOS group compared to the control group (7.3% ± 2.1% vs. 5.6% ± 0.6%, P < 0.001). The multivariate analysis showed a strong correlation between elevated HbA1c levels and PCOS , P < 0.001). In the PCOS group, higher HbA1c values were significantly correlated with a higher socio-economic status ), P = 0.018) and with obesity (OR 3.48 IC (1.31 -7.13) P = 0.029). A perfect, positive and significant linear correlation was found between HbA1c and fasting blood glucose (r = 0.807). 60% of women in the PCOS group had pathological values of HbA1c (≥6.5%) compared to 7.7% in the control group (P < 0.001). Oligomenorrhea was found more significantly in patients with pathological HbA1c values (≥6.5%) compared to those with values < 6.5% (P = 0.003). Conclusion: This study found that in our population 60% of women with PCOS had states of hyperglycemia, demanding systematic screening of glucose metabolism disorders in women with this syndrome.

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Increased mean glucose levels in patients with polycystic ovary syndrome and hyperandrogenemia as determined by continuous glucose monitoring

Abstract: Polycystic ovarian syndrome patients with hyperandrogenemia had an increased mean glucose value, which may place them at increased risk for developing type 2 diabetes.

Cited by 18 publications

References 46 publications

Phyllanthus muellerianus(Euphorbiaceae) Restores Ovarian Functions in Letrozole-Induced Polycystic Ovarian Syndrome in Rats

Phyllanthus muellerianus(Euphorbiaceae) Restores Ovarian Functions in Letrozole-Induced Polycystic Ovarian Syndrome in Rats

Effects of hyperandrogenism on metabolic abnormalities in patients with polycystic ovary syndrome: a meta-analysis

Importance of the Glycated Hemoglobin Assay in Congolese Women with Polycystic Ovary Syndrome: A Case-Control Study in Kinshasa, DR Congo

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