Increased mean platelet volume in cervicocephalic artery dissections

Kamışlı, Özden; Kamışlı, Suat; Gönüllü, Sinan; Kaplan, Yüksel; Özcan, Cemal

doi:10.1007/s11845-012-0820-y

Cited by 4 publications

(3 citation statements)

References 25 publications

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“…Signs of PLT consumption (low PLT count and/or increased MPV) have been described in uncomplicated abdominal aortic aneurysms [4,5], possibly due to PLT activation within the aneurysmal sac; we documented low PLT count only in AAD. One study showed elevated MPV values in patients with vertebral artery dissection [7]. We noticed only a trend towards lower MPV concentrations but a significant higher ratio of MPV/ PLT in dissection; the latter being more pronounced in type A dissection compared to type B.…”

contrasting

confidence: 62%

Significant changes in platelet count, volume and size in acute aortic dissection

Sbarouni

Γεωργιάδου

Analitis

et al. 2013

International Journal of Cardiology

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contrasting

confidence: 62%

Significant changes in platelet count, volume and size in acute aortic dissection

Sbarouni

Γεωργιάδου

Analitis

et al. 2013

International Journal of Cardiology

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“…Previous studies (11) have shown that patients with acute aortic dissection and aortic aneurysm have lower platelet counts and a higher platelet average volume/platelet count ratio. The related research on the death of dissection shows that the preoperative platelet count is lower and the ratio of platelet average volume to platelet count is higher, which in turn increases the incidence of postoperative complications, increases the postoperative mortality and affects the prognosis (12)(13)(14). The results of this study show that there is a significant difference between the preoperative platelet volume in the postoperative death group and the survival group of patients with dissection, the former is higher than the latter, and the preoperative platelet volume is an independent risk factor for postoperative death, which is predictive for postoperative death risk.…”

Section: Discussionmentioning

confidence: 99%

Development and evaluation of an early death risk prediction model after acute type A aortic dissection

Zhang¹,

Chen²,

Chen³

et al. 2021

Ann Transl Med

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Background: The purpose of the study was to assess the relationship between preoperative laboratory examination, clinical imaging data, and postoperative death of patients with acute type A aortic dissection (ATAAD) and to establish a prediction model of hospital death risk after the operation.Methods: A total of 224 cases of acute Standford A aortic dissection were treated by total arch replacement using a tetrafurcate graft with stented elephant trunk implantation in Tianjin Chest Hospital. Based on preoperative laboratory examination and clinical imaging data of patients with ATAAD, the independent risk factors of postoperative hospital death were obtained using logistic analysis, and a risk prediction model of postoperative hospital death was developed. Results: Independent risk factors of postoperative death in patients with ATAAD were: body mass index (BMI), preoperative neutrophil to lymphocyte ratio (NLR), mean platelet volume (MPV), creatinine (Cr), D-dimer, high-sensitive cardiac troponin T (hs-CTnT), apolipoprotein A1, left subclavian artery involvement, and iliac artery involvement. The regression equation of postoperative death risk was: logitP1 = −9.584 + 1.060 × NLR + 1.586 × MPV + 1.009 × Cr + 1.067 × D-dimer + 2.023 × hs-CTnT; the regression equation of postoperative death risk was: logitP2 = −3.296 + 3.242 × left subclavian artery involved + 4.564 × iliac artery involved; the regression equation of postoperative death risk was: logitP3 = −12.864 + 1.149 × BMI + 4.731 × left subclavian artery involved + 4.150 × iliac artery involved + 1.064 × NLR + 1.011 × Cr + 1.084 × D-dimer + 2.242 × hs-CTnT + 3.233 × apolipoprotein A1.Conclusions: BMI, NLR, MPV, Cr, D-dimer, hs-CTnT, apolipoprotein A1, left subclavian artery involvement and iliac artery involvement can affect the hospital mortality rate of aortic dissection undergoing Sun's operation to varying degrees, which may be helpful to guide the design of the perioperative treatment strategy.

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“…The inflammatory response caused by thrombus formation in the false lumen of aortic dissection can promote platelet activation, further accelerate the consumption of platelets, and ultimately affect the prognosis of patients [ 18 ]. Research has also suggested that platelet function and activity were closely related to cervicocephalic artery dissections [ 19 ]. These conclusions are consistent with our findings that low preoperative platelet count is an independent risk factor for in-hospital mortality in patients with acute type A aortic dissection after surgery.…”

Section: Discussionmentioning

confidence: 99%

A novel nomogram model to predict in-hospital mortality in patients with acute type A aortic dissection after surgery

Zhou,

Fan,

Jiang

et al. 2024

J Cardiothorac Surg

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Background Acute type A aortic dissection is a dangerous disease that threatens public health. In recent years, with the progress of medical technology, the mortality rate of patients after surgery has been gradually reduced, leading that previous prediction models may not be suitable for nowadays. Therefore, the present study aims to find new independent risk factors for predicting in-hospital mortality and construct a nomogram prediction model. Methods: The clinical data of 341 consecutive patients in our center from 2019 to 2023 were collected, and they were divided into two groups according to the death during hospitalization. The independent risk factors were analyzed by univariate and multivariate logistic regression, and the nomogram was constructed and verified based on these factors. Results: age, preoperative lower limb ischemia, preoperative activated partial thromboplastin time (APTT), preoperative platelet count, Cardiopulmonary bypass (CPB) time and postoperative acute kidney injury (AKI) independently predicted in-hospital mortality of patients with acute type A aortic dissection after surgery. The area under the receiver operating characteristic curve (AUC) for the nomogram was 0.844. The calibration curve and decision curve analysis verified that the model had good quality. Conclusion: The new nomogram model has a good ability to predict the in-hospital mortality of patients with acute type A aortic dissection after surgery.

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Increased mean platelet volume in cervicocephalic artery dissections

Cited by 4 publications

References 25 publications

Significant changes in platelet count, volume and size in acute aortic dissection

Significant changes in platelet count, volume and size in acute aortic dissection

Development and evaluation of an early death risk prediction model after acute type A aortic dissection

A novel nomogram model to predict in-hospital mortality in patients with acute type A aortic dissection after surgery

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